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Endosomal TLRs play an important role in systemic autoimmune diseases, such as systemic erythematosus lupus, in which DNA- and RNA-associated autoantigens activate autoreactive B cells through TLR9- and TLR7-dependent pathways. 
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Sociodemographic and geographic predictors of quality of care in US patients with end-stage lupus nephritis http://t.co/88kP2WttYr
Abstract Objective. To describe end-stage renal disease (ESRD) quality of care (receipt of pre-ESRD nephrology care, access to kidney transplantation, and permanent vascular access placement for dialysis) in U.S. patients with ESRD due to lupus nephritis (LN-ESRD) and examine whether quality measures differed by patient sociodemographics or U.S. region. Methods. In 6,594 U.S. patients initiating treatment for LN-ESRD (7/05-9/11), we estimated odds ratios (ORs) and hazard ratios (HRs) of each quality measure with sociodemographics and U.S. region using national surveillance data. Results. Overall, 71% received nephrology care prior to ESRD. Blacks and Hispanics were less likely than whites to receive pre-ESRD care (OR=0.73, 95% CI 0.63-0.85 and OR=0.72, 95% CI 0.60-0.88) and to be placed on the kidney transplant waitlist (HR=0.78, 95% CI 0.68-0.81 and HR=0.82, 95% CI 0.68-0.98). Those with Medicaid (HR=0.51, 95% CI 0.44-0.58) or no insurance (HR=0.36, 95% CI 0.29-0.44) were less likely than those with private insurance to be placed on the waitlist. Only 24% had a permanent vascular access, and placement was even less likely among the uninsured (OR=0.62, 95% CI 0.49-0.79). ESRD quality-of-care measures varied 2- to 3-fold across regions, with patients in the Northeast and Northwest generally having higher probabilities of adequate care. Via Krishan Maggon
Krishan Maggon 's curator insight,
February 24, 2015 1:58 AM
Further studies are warranted to examine multi-level barriers to—and develop targeted interventions to improve delivery of—care among LN-ESRD patients. DOI: 10.1002/art.38983 Copyright © 2014 American College of Rheumatology Issue Arthritis & RheumatologyAccepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)
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Chronic inflammatory conditions, such as in autoimmune disease, can disturb immune cell homeostasis and induce the expansion of normally rare cell populations.
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Proc Natl Acad Sci U S A. 2015 Feb 2. pii: 201420217. [Epub ahead of print]Full text in PNAS
Gilbert C FAURE's insight:
Cytosolic DNA-sensing pathways that signal via Stimulator of interferon genes (STING) mediate immunity to pathogens and also promote autoimmune pathology in DNaseII- and DNaseIII-deficient mice. In contrast, we report here that STING potently suppresses inflammation in a model of systemic lupus erythematosus (SLE)
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Evaluation of B lymphocyte stimulator and a proliferation inducing ligand as candidate biomarkers in lupus nephrit... http://t.co/78vzFQCDny
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The American Diabetes Association has awarded La Jolla Institute researcher Stephanie Stanford, Ph.D., a $1.6 million grant to investigate the genetic and environmental factors that trigger the onset of type 1 diabetes. Via Ellen H Ullman, MSW
Gilbert C FAURE's insight:
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
"We believe that when the PTPN22 gene is mutated, it impairs the body's immune response to viral infections, especially a specific enterovirus that is known to trigger type 1 diabetes by leaving the body vulnerable to an attack on the pancreas," Dr. Stanford said. "We also believe that certain environmental factors, including exposure to pathogens early in life, contribute to increased risk of type 1 diabetes."
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by Wei Jiang, Lumin Zhang, Ren Lang, Zihai Li, Gary Gilkeson
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Complications of neuropsychiatric systemic lupus erythematosus (NP-SLE) are associated with the morbidity and mortality of patients with SLE.
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Th17 cells infiltrate the kidneys of patients with lupus nephritis (LN) and are critical for the pathogenesis of this disease.
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Preclinical lupus encompasses a spectrum from enhanced SLE risk without clinical symptoms to individuals with autoantibodies and some SLE clinical features without meeting ACR classification. Studies have identified antibody and serological biomarkers years before disease onset. Incomplete lupus and undifferentiated connective tissue disease may occur during preclinical disease periods, but only 10–20% of these individuals transition to SLE and many have a mild disease course. Further studies are warranted to characterize biomarkers of early disease, identify individuals in need of close monitoring or preventive interventions, and elucidate mechanisms of disease pathogenesis without confounding factors of immunosuppressive medications or organ damage. Via Krishan Maggon
Krishan Maggon 's curator insight,
October 28, 2014 3:05 AM
Rheumatic Disease Clinics of North America
Volume 40, Issue 4, November 2014, Pages 621–635 Preclinical Rheumatic Disease Preclinical Systemic Lupus Erythematosus Julie M. Robertson, PhDa, Judith A. James, MD, PhDa, b, c, d, , DOI: 10.1016/j.rdc.2014.07.004
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is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model.
Gilbert C FAURE's insight:
Activated RF B cells preferentially differentiated into plasmablasts in EF zones. Contrary to the MRL/lpr strain, TC RF B cells were also located within germinal centers, but only the formation of EF foci was positively correlated with the production of RF AFCs. Immunization of young TC.AM14 H chain transgenic mice with IgG2a(a) anti-chromatin immune complexes (ICs) activated RF B cells in a BCR- and TLR9-dependent manner. However, these IC immunizations did not result in the production of RF AFCs. These results show that RF B cells break tolerance with the same general mechanisms in the TC and the MRL/lpr lupus-prone genetic backgrounds, namely the dual activation of the BCR and TLR9 pathways.
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by Qing Lu, Ji-Yang Wang, Luman Wang, Xuechao Jiang, Yiwei Chu
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Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus [AUTOIMMUNITY] http://t.co/EztFkk6NOS #jimmTCB
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From
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UAB is testing a tablet-based decision aid in hopes of improving outcomes for minority women with lupus and kidney disease Jasvinder SinghResearchers...
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As the Lupus Research Institute celebrates its 15th anniversary, the engine of innovation moves forward at accelerated speed with the announcement of this year's Novel Research Grants bringing new talent from a wide diversity of specialties.
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BioMed Research International (formerly titled Journal of Biomedicine and Biotechnology) is a peer-reviewed, open access journal that publishes original research articles as well as review articles in several areas of life sciences.
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Evaluation of B lymphocyte stimulator and a proliferation inducing ligand as candidate biomarkers in lupus nephrit... http://t.co/78vzFQCDny
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Rheumatology | Patients with systemic lupus erythematosus were shown to have higher levels of T helper 17 cells than healthy controls, according to study findings.A cohort of 48 women diagnosed with systemic lupus erythematosus (SLE) based on...
Gilbert C FAURE's insight:
not in serum, in blood
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The multifaceted aspects of refractory lupus nephritis: Expert Review of Clinical Immunology, Ahead of Print.
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AntidsDNA antibodies as aclassification criterion and a diagnostic marker for SEL Clinical & Experimental Immunology http://t.co/BhTBDH89sn
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Background/Purpose: Complications of neuropsychiatric systemic lupus erythematosus (NP-SLE) are associated with the morbidity and mortality of patients with SLE.
Gilbert C FAURE's curator insight,
November 21, 2014 10:03 AM
among searchable ACR abstracts 2012-2013-2014
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Eur J Immunol. 2014 Oct 29. doi: 10.1002/eji.201444760. [Epub ahead of print]
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RT @ElWheet: May be a reasonable strategy. "Belimumab after rituximab as maintenance therapy in lupus nephritis" http://t.co/i4Wtdfo0Wk
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Spontaneous germinal center (Spt-GC) B cells and follicular helper T cells generate high-affinity autoantibodies that are involved in the development of systemic lupus erythematosus.
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by Li Cai, Jin-wei Zhang, Xing-xin Xue, Zhi-gang Wang, Jia-jia Wang, Shai-di Tang, Shao-wen Tang, Jie Wang, Yun Zhang, Xian Xia
Krishan Maggon 's curator insight,
October 8, 2014 6:19 AM
open access
PLoS One
OPEN ACCESS PEER-REVIEWEDRESEARCH ARTICLEMeta-Analysis of Associations of IL1 Receptor Antagonist and Estrogen Receptor Gene Polymorphisms with Systemic Lupus Erythematosus SusceptibilityLi Cai equal contributor, Jin-wei Zhang equal contributor, Xing-xin Xue, Zhi-gang Wang, Jia-jia Wang, Shai-di Tang, Shao-wen Tang, Jie Wang, Yun Zhang mail, Xian Xia mail Published: October 06, 2014DOI: 10.1371/journal.pone.0109712 |
