AUTOIMMUNITY
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The West Australian Diabetes trigger found by WA team The West Australian Part of a global consortium, scientists from the Harry Perkins Institute for Medical Research have identified an area of DNA linked to the autoimmune condition that affects...
Gilbert C FAURE's insight:
cathepsine? 
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Gilbert C FAURE's insight:
1991 a pillar
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A reverse vaccine that shuts down the destructive immune response against insulin-producing beta cells helped preserve pancreatic function in patients with type 1 diabetes, researchers reported.
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GAD Autoantibody Affinity in Adult Patients With Latent Autoimmune Diabetes, the Study Participants of a GAD65... http://t.co/k7E0B0qFcw
Gilbert C FAURE's insight:
RESEARCH DESIGN AND METHODS GADA affinity was measured in sera of 46 LADA patients obtained prior to the first week and 20 weeks after the second injection with GAD-alum or placebo using competitive binding experiments with [125I]-labeled and unlabeled human GAD65.
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UF Health Pathology Laboratories' Endocrine Autoantibody Laboratory makes autoantibody marker testing available for nearly 20 endocrine-related disorders, including Type 1 diabetes mellitus (T1DM). Our pathologists have ...
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NEW ARTICLE: Decreased miR-146 Expression in Peripheral Blood Mononuclear Cell Correlated with Ongoing islet autoi... http://t.co/0dKBldBk23
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Potential diabetes therapy: scientists grow insulin-producing cells using ...
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OBJECTIVE Diabetes-associated autoantibodies can be detected in adult-onset diabetes, even when initially non–insulin requiring, i.e., with latent autoimmune diabetes. We aimed to identify adult-onset autoimmune diabetes ...
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Just published: TCF7L2 variation and single islet autoantibody expression in children with type 1 diabetes. http://t.co/ckJYK4LGKl #diabetes
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Microbial DNA may be involved in the development of autoimmune processes ...
Gilbert C FAURE's insight:
type I diabetes in BABYDIeT study
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Type 1 diabetes in adults: Antibody affinity is decisive http://t.co/INzDzvtNfs
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![Islet Antigen-Specific Th17 Cells Can Induce TNF-{alpha}-Dependent Autoimmune Diabetes [AUTOIMMUNITY] | AUTOIMMUNITY | Scoop.it](https://img.scoop.it/0kC-b95Z4baJE9o0fGtLWDl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
Type 1 diabetes (T1D) results from autoimmune destruction of pancreatic β-cells. Although Th1 cells are key orchestrators of T1D, the function(s) of the more recently identified Th17 subset are unclear due to inherent plasticity.
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How did we discover that #diabetes #type1 was an autoimmune disease? Read more: http://t.co/gmNRD8uVA2
Gilbert C FAURE's insight:
GF Bottazo himself
Gilbert C FAURE's curator insight,
October 3, 2014 9:51 AM
history of autoimmunity with pictures of a few people involved
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Also, persons with type 1 diabetes are prone to other autoimmune disorders, such as autoimmune thyroid disease. In cases that are less than clear-cut, measuring autoantibodies can provide useful information.
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Medical Daily Reversal of type 1 diabetes in mice may eventually help humans Medical Xpress Researchers say the incidence of Type 1 diabetes and autoimmunity in general has risen rapidly since the mid-20th century, possibly the result of...
Gilbert C FAURE's insight:
anti-TLR4... ubiquitous innate molecule, take care of potential side effects
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The rheumatoid arthritis drug, abatacept, has shown evidence that it can delay the progression of type 1 diabetes a year after discontinuation of the treatment.
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:
type I Diabetes
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From BioPortfolio: Juvenile Diabetes Cure Alliance report analyzes cure research projects that have the potential to change the lives of people with type 1. New York, NY (PRWEB) M...
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Kids' Diabetes Rates Up Dramatically in 8 Years, Study Finds Via Remi Creusot
Remi Creusot's curator insight,
May 6, 2014 9:27 AM
This study confirms the already suspected rate of increased T1D and T2D incidence in children. This follows the even more dramatic trend of about 3% increase per year in Europe. More and more studies are now turning to how or lifestyle influences this.
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A Sweet Life LADA and GAD: Diagnosing Type 1.5 Diabetes A Sweet Life GAD is one of the earliest proteins to be targeted by antibodies, and so by testing for the presence of GAD antibodies, doctors can determine whether there is an autoimmune...
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Diabetes prevention scoring system improved accuracy of type 1 risk classification Healio “The findings indicate that a reliance upon dysglycemia as a demarcation of risk in autoantibody-positive populations could result in a less-than-optimal...
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Autoreactive B cells are essential for the pathogenesis of type 1 diabetes. The genesis and dynamics of autoreactive B cells remain unknown.
Gilbert C FAURE's insight:
..... analyzed the immune response in the NOD mouse model to the neuronal protein peripherin (PRPH) http://en.wikipedia.org/wiki/Peripherin, a target Ag of islet-infiltrating B cells. PRPH autoreactive B cells recognized a single linear epitope of this protein, in contrast to the multiple epitope recognition commonly observed during autoreactive B cell responses. Autoantibodies to this epitope were also detected in the disease-resistant NOR and C57BL/6 strains.
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Evidence of anti-islet cell autoimmunity in type 1 diabetes appears in the first years of life, however little is known regarding establishment of the gut microbiome in early infancy. Here, we sought to ...
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Author: Haskins K, Journal: Current opinion in immunology[2011/12], Abstract: Pathogenesis of type 1 diabetes (T1D) is mediated by effector T cells and CD4 Th1 and Th17T cells have important roles in this process.
Gilbert C FAURE's insight:
2011
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