AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
July 30, 2015 4:08 PM
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Promising progress for new treatment of type 1 diabetes

New research shows promising progress in the use of anti-inflammatory cytokine for treatment of type 1 diabetes.
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IL-35

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Scooped by Gilbert C FAURE
July 21, 2015 5:20 AM
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Functional analyses of polymorphic variants of human terminal deoxynucleotidyl ... - Nature.com

Functional analyses of polymorphic variants of human terminal deoxynucleotidyl ...
Nature.com
Absence of TdT in inbred mice has been shown to correlate with decreased severity of autoimmune diseases, such as lupus and diabetes.
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Scooped by Gilbert C FAURE
July 9, 2015 1:21 AM
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The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases

The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases | AUTOIMMUNITY | Scoop.it
Dendritic cells (DCs) are key antigen-presenting cells that have an important role in autoimmune pathogenesis. DCs control both steady-state T cell tolerance and activation of pathogenic responses.
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Scooped by Gilbert C FAURE
June 30, 2015 10:50 AM
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New insights and biomarkers for Type 1 Diabetes: Review for Scandinavian Journal of Immunology. - PubMed - NCBI

New insights and biomarkers for Type 1 Diabetes: Review for Scandinavian Journal of Immunology. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
Scand J Immunol. 2015 Jun 28. doi: 10.1111/sji.12338. [Epub ahead of print]
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Scooped by Gilbert C FAURE
June 18, 2015 4:18 PM
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Diabetes: Primary prevention for type 1 diabetes mellitus? - Nature.com

Diabetes: Primary prevention for type 1 diabetes mellitus?
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Scooped by Gilbert C FAURE
June 10, 2015 11:37 AM
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Use of Autoantigen-Loaded Phosphatidylserine-Li...

Use of Autoantigen-Loaded Phosphatidylserine-Li... | AUTOIMMUNITY | Scoop.it
Introduction The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes.
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Scooped by Gilbert C FAURE
May 29, 2015 2:18 PM
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Detection of antibodies directed to the N-terminal region of GAD is dependent on assay format and contributes to differences in the specificity of GAD autoantibody assays for type 1 diabetes

Detection of antibodies directed to the N-terminal region of GAD is dependent on assay format and contributes to differences in the specificity of GAD autoantibody assays for type 1 diabetes | AUTOIMMUNITY | Scoop.it
Endocrinology Article: Detection of antibodies directed to the N-terminal region of GAD is dependent on assay format and contributes to differences in the specificity of GAD autoantibody assays for type 1 diabetes...
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Scooped by Gilbert C FAURE
May 11, 2015 1:37 PM
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One step closer to an insulin vaccine for type 1 diabetes - HealthCanal.com

One step closer to an insulin vaccine for type 1 diabetes - HealthCanal.com | AUTOIMMUNITY | Scoop.it
One step closer to an insulin vaccine for type 1 diabetes
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Scooped by Gilbert C FAURE
April 29, 2015 2:18 PM
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Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: C... - PubMed - NCBI

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: C... - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
Diabetes. 1998 Dec;47(12):1857-66. Congresses; Research Support, Non-U.S. Gov't
Gilbert C FAURE's insight:

1998!

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Scooped by Gilbert C FAURE
April 24, 2015 1:22 PM
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High-Dose Oral Insulin Promising for Preventing T1DM in At-Risk Children - Monthly Prescribing Reference

High-Dose Oral Insulin Promising for Preventing T1DM in At-Risk Children - Monthly Prescribing Reference | AUTOIMMUNITY | Scoop.it
In a pilot study described in the latest issue of JAMA, daily treatment with a highdose oral insulin in children at high risk for type 1 diabetes led to an immune response to insulin without hypoglycemia.
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Scooped by Gilbert C FAURE
April 23, 2015 7:15 AM
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Oral Insulin and Immune Responses in Children at Risk for Diabetes

Oral Insulin and Immune Responses in Children at Risk for Diabetes | AUTOIMMUNITY | Scoop.it
This trial reports immune responses to insulin among children at risk for type 1 diabetes randomized to oral insulin vs placebo in an attempt to increase immune tolerance.
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Scooped by Gilbert C FAURE
April 12, 2015 3:36 PM
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Swedish scientists find new markers for type 1 diabetes - Fox News

Swedish scientists find new markers for type 1 diabetes - Fox News | AUTOIMMUNITY | Scoop.it
Doctors may be able to detect type 1 diabetes in children before they exhibit any symptoms of the disease, new research from Sweden shows.
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Suggested by Société Francaise d'Immunologie
March 14, 2015 10:41 AM
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Interleukin-10+ regulatory B cells arise within antigen-experienced... - PubMed - NCBI

Diabetes. 2015 Jan;64(1):158-71. doi: 10.2337/db13-1639. Epub 2014 Sep 3. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Scooped by Gilbert C FAURE
July 27, 2015 8:46 AM
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Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study.

Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study. | AUTOIMMUNITY | Scoop.it
Authors: Carina Törn, David Hadley, Hye-Seung Lee, William Hagopian, Åke Lernmark, Olli Simell, Marian Rewers, Anette Ziegler, Desmond Schatz, Beena Akolkar, Suna Onengut-Gumuscu, Wei-Min Chen, Jorma Toppari, Juha Mykkänen, Jorma Ilonen, Stephen S...
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Scooped by Gilbert C FAURE
July 13, 2015 5:26 AM
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Reversal of New-Onset Type 1 Diabetes with an agonistic TLR4/MD-2 Monoclonal Antibody

Reversal of New-Onset Type 1 Diabetes with an agonistic TLR4/MD-2 Monoclonal Antibody | AUTOIMMUNITY | Scoop.it
Reversal of New-Onset Type 1 #Diabetes with an Agonistic TLR4/MD-2 Monoclonal Antibody http://t.co/9hWH5P3Aem
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Scooped by Gilbert C FAURE
July 4, 2015 3:26 PM
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The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases. - PubMed - NCBI

The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
Front Immunol. 2015 Jun 15;6:288. doi: 10.3389/fimmu.2015.00288. eCollection 2015. Review
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Scooped by Gilbert C FAURE
June 29, 2015 12:19 PM
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Evidence for Residual and Partly Reparable Insulin Secretory Function and Maintained β-Cell Gene Expression in Islets From Patients With Type 1 Diabetes

Evidence for Residual and Partly Reparable Insulin Secretory Function and Maintained β-Cell Gene Expression in Islets From Patients With Type 1 Diabetes | AUTOIMMUNITY | Scoop.it
Diabetes: Evidence for Residual and Partly Reparable Insulin Secretory Function T1D http://t.co/zTuBgt7x0K
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Scooped by Gilbert C FAURE
June 17, 2015 2:39 PM
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Antibody holds promise for treatment of type 1 diabetes - Medical Xpress

Antibody holds promise for treatment of type 1 diabetes - Medical Xpress | AUTOIMMUNITY | Scoop.it
Type 1 diabetes, which usually appears in children and adolescents, affects over 30 million people worldwide.
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Scooped by Gilbert C FAURE
June 2, 2015 11:46 AM
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JCI - MicroRNA regulation of lymphocyte tolerance and autoimmunity

JCI - MicroRNA regulation of lymphocyte tolerance and autoimmunity | AUTOIMMUNITY | Scoop.it
MicroRNA regulation of lymphocyte tolerance and autoimmunity: Understanding the cell-intrinsic cues that permi... http://t.co/bhaplFv5ib
Gilbert C FAURE's insight:

Understanding the cell-intrinsic cues that permit self-reactivity in lymphocytes, and therefore autoimmunity, requires an understanding of the transcriptional and posttranscriptional regulation of gene expression in these cells. In this Review, we address seminal and recent research on microRNA (miRNA) regulation of central and peripheral tolerance. Human and mouse studies demonstrate that the PI3K pathway is a critical point of miRNA regulation of immune cell development and function that affects the development of autoimmunity. We also discuss how miRNA expression profiling in human autoimmune diseases has inspired mechanistic studies of miRNA function in the pathogenesis of multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, and asthma.

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Scooped by Gilbert C FAURE
May 11, 2015 1:37 PM
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Drak2 Does Not Regulate TGF-β Signaling in T Cells

Drak2 Does Not Regulate TGF-β Signaling in T Cells | AUTOIMMUNITY | Scoop.it
by Tarsha L. Harris, Maureen A. McGargill
Drak2 is a serine/threonine kinase expressed highest in T cells and B cells. Drak2-/- mice are resistant to autoimmunity in mouse models of type 1 diabetes and multiple sclerosis.
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Scooped by Gilbert C FAURE
May 11, 2015 1:04 PM
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A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes. - PubMed - NCBI

A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
Diabetologia. 2015 May 10. [Epub ahead of print]
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Scooped by Gilbert C FAURE
April 29, 2015 6:07 AM
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Oral insulin shows potential for preventing type 1 diabetes in high-risk children - Science Daily

Oral insulin shows potential for preventing type 1 diabetes in high-risk children - Science Daily | AUTOIMMUNITY | Scoop.it
In a pilot study that included children at high risk for type 1 diabetes, daily high-dose oral insulin, compared with placebo, resulted in an immune response to insulin without hypoglycemia, findings that support the need for a phase 3 trial to...
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Scooped by Gilbert C FAURE
April 24, 2015 7:21 AM
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Testing for Autoimmunity and β -Cell Function in a Young Patient with Diabetes Mellitus: A Case Report | Atanacio | Journal of the ASEAN Federation of Endocrine Societies

Testing for Autoimmunity and β -Cell Function in a Young Patient with Diabetes Mellitus: A Case Report | Atanacio | Journal of the ASEAN Federation of Endocrine Societies | AUTOIMMUNITY | Scoop.it
Testing for Autoimmunity and β -Cell Function in a Young Patient with Diabetes Mellitus: A Case Report
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Scooped by Gilbert C FAURE
April 13, 2015 1:40 PM
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Islet autoantibody status in a multi-ethnic UK clinic cohort of children presenting with diabetes -- Perchard et al. 100 (4): 348 -- Archives of Disease in Childhood

Islet autoantibody status in a multi-ethnic UK clinic cohort of children presenting with diabetes http://t.co/7sW1pKQTqj
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Scooped by Gilbert C FAURE
March 22, 2015 5:20 AM
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A new approach for diagnosing type 1 diabetes in autoantibody-posit... - PubMed - NCBI

Diabetes Care. 2015 Feb;38(2):271-6. doi: 10.2337/dc14-1813. Epub 2014 Dec 17. Research Support, N.I.H., Extramural
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