 Your new post is loading...
Your new post is loading...
Scoop.it!
RT @Immunology_News: Enhanced autoantibody production and Mott cell formation in Fc{mu}R-deficient autoimmune mice http://t.co/YlP9ijruhz 
No comment yet.
Sign up to comment
Scoop.it!
What a clinician needs to know about autoantibody assays: value added reporting of autoimmune serology - http://t.co/kELJH8ddUP
Scoop.it!
Anti-dsDNA, surface-expressed TLR4 and endosomal TLR9 cooperate to ...
Gilbert C FAURE's insight:
bis?
Scoop.it!
SLAP deficiency decreases dsDNA autoantibody production - Europe PMC Article - Europe PubMed CentralFULL TEXT Abstract: Src-like adaptor protein (SLAP) adapts c-Cbl, an E3 ubiquitin ligase, to activated components of the BCR signaling complex regulating BCR levels...
Scoop.it!
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:
a review on the role of glycosylation...
Scoop.it!
GAD Autoantibody Affinity in Adult Patients With Latent Autoimmune Diabetes, the Study Participants of a GAD65... http://t.co/k7E0B0qFcw
Gilbert C FAURE's insight:
RESEARCH DESIGN AND METHODS GADA affinity was measured in sera of 46 LADA patients obtained prior to the first week and 20 weeks after the second injection with GAD-alum or placebo using competitive binding experiments with [125I]-labeled and unlabeled human GAD65.
Scoop.it!
Thus, the anti-β2GP1 autoantibody/β2GP1 complex binds to the thrombus, enhancing platelet activation, and platelet secretion leads to enhanced endothelium activation and fibrin generation. These results lead to a paradigm ...
Gilbert C FAURE's insight:
blood paper
Scoop.it!
Neural autoantibody clusters aid diagnosis of cancer
Scoop.it!
UF Health Pathology Laboratories' Endocrine Autoantibody Laboratory makes autoantibody marker testing available for nearly 20 endocrine-related disorders, including Type 1 diabetes mellitus (T1DM). Our pathologists have ...
Scoop.it!
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:
data demonstrate faster progression of SSc in autoantibody-positive patients, particularly in those with preclinical internal organ involvement at baseline, than in autoantibody-negative patients. obviously?
Scoop.it!
Atypical adenomatous hyperplasia (AAH) and squamous cell dysplasia (SCD) are associated with the development of malignant lesions in the lung. Accurate diagnosis of AAH and SCD could facilitate earlier clinical ...
Gilbert C FAURE's insight:
Sensitivity of 82% and specificity of 70% were achieved in the detection of AAH using a combination of 9 autoantibody biomarkers. Likewise, 86% sensitivity and 78% specificity were achieved in the detection of SCD using a combination of 13 SCD-associated markers. Sequencing analysis identified that most of these 22 autoantibody biomarkers had known malignant associations.
Scoop.it!
From
drc
Just published: TCF7L2 variation and single islet autoantibody expression in children with type 1 diabetes. http://t.co/ckJYK4LGKl #diabetes
Scoop.it!
by Christie Fitch-Rogalsky, Whitney Steber, Michael Mahler, Terri Lupton, Liam Martin, Susan G. Barr, Dianne P. Mosher, James Wick, Marvin J.
Gilbert C FAURE's insight:
This is the first study to evaluate the serological and clinical features of patients referred through a CT system because of a positive ANA. The spectrum of autoantibody specificities was wide with anti-Ro52/TRIM21 being the most common autoantibody detected. Approximately 15% of referrals had only antibodies to DFS70, the vast majority of which did not have clinical evidence for an AARD. These findings provide insight into the utility of autoantibody testing in a CT system.
|
Scoop.it!
It is not known whether or not this risk is associated with angiotensin II receptor type 1 autoantibody (AT1-AA), an agonist acting via activation of AT1 receptor (AT1R), which is believed to be involved in the pathogenesis of ...
Gilbert C FAURE's insight:
preclampsia...
Scoop.it!
Dogs with #Pemphigus foliaceus rarely have IgM, IgA, IgE autoantibodies, IgG autoantibody response predominant type http://t.co/btuWsSEQdP
Scoop.it!
Reciprocal adoptive transfer studies confirm that autoantibody production and arthritis are modulated by IDO2 expression in a cell type extrinsic to the T cell. Taken together, our results, provide important insights into IDO2 ...
Scoop.it!
The study of cancer immunology has provided diagnostic and therapeutic instruments through serum autoantibody biomarkers and exogenous monoclonal antibodies.
Scoop.it!
MedPage Today RheumShorts: Turmeric, Kids' Vasculitis, Autoantibodies MedPage Today This week in rheumatology, researchers from around the world reported on the use of curcuminoids for osteoarthritis, autoantibody monitoring for drug-induced lupus,...
Gilbert C FAURE's insight:
Routine monitoring for antinuclear antibodies (ANA) did not help predict the development of drug-induced lupus among patients with rheumatoid arthritis receiving TNF inhibitors, British researchers reported. Among 454 patients enrolled in a U.K. biologic database who underwent serial testing for the development of ANA, 83 seroconverted by a median time of 2 years, and six developed antibodies to double-stranded DNA (dsDNA). Three patients were diagnosed with lupus, according to Maya H. Buch, MBChB, PhD, of Leeds University, and colleagues.
Scoop.it!
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Scoop.it!
From
www
Video articles in JoVE about autoimmunity include "Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes", "The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice", "Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model", "Granulocyte-dependent Autoantibody-induced Skin Blistering", "Examination of Thymic Positive and Negative Selection by Flow Cytometry", "Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation", "A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions", "Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE", "Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation", "Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis".
Gilbert C FAURE's insight:
38 results on may 2014
Scoop.it!
From
jrheum
Arthritis in Idiopathic Inflammatory Myopathy: Clinical Features and Autoantibody Associations from @jrheum http://t.co/mECfKDqanw
Scoop.it!
Systemic lupus erythematosus is a multisystem autoimmune disease characterized by autoantibodies targeting nucleic acid–associated Ags.
Scoop.it!
Diabetes prevention scoring system improved accuracy of type 1 risk classification Healio “The findings indicate that a reliance upon dysglycemia as a demarcation of risk in autoantibody-positive populations could result in a less-than-optimal...
Scoop.it!
Objective: Familial clustering of juvenile autoimmune liver disease (AILD), including autoimmune hepatitis and autoimmune sclerosing cholangitis (ASC), is rare, despite a high prevalence of autoimmune disorders in AILD families.
Scoop.it!
Activation of the classical pathway of complement (CP) is often associated with autoimmune disorders in which disease pathology is linked to the presence of an autoantibody. One such disorder is cold agglutinin disease ...
|
IgM-Fc receptor (FcμR) is involved in IgM homeostasis as evidenced by increased pre-immune serum IgM and natural autoantibodies of both IgM and IgG isotypes in Fcmr-deficient C57BL/6 (B6) mice. To determine the impact of Fcmr ablation on autoimmunity, we introduced the Fcmr null mutation onto the Fas-deficient autoimmune-prone B6.MRL Faslpr/lpr mouse background (B6/lpr).