AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
April 12, 2015 3:39 PM
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B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production. - PubMed - NCBI

B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
From www.ncbi.nlm.nih.gov - April 8, 2015 12:03 PM
Curr Opin Immunol. 2015 Feb 10;33C:70-77. doi: 10.1016/j.coi.2015.01.018. [Epub ahead of print] REVIEW
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Scooped by Gilbert C FAURE
April 4, 2015 4:27 PM
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Science Translational Medicine | From AAAS

From m.stm.sciencemag.org - March 31, 2015 8:40 AM
RT @ARD_BMJ: Blocking #autoantibody generation in the initiation of rheumatoid #arthritis #rheumedu http://t.co/7WvbKfCCDt
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Scooped by Gilbert C FAURE
March 31, 2015 2:03 PM
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Therapeutics to block autoantibody initiation a...

Therapeutics to block autoantibody initiation a... | AUTOIMMUNITY | Scoop.it
From www.scoop.it - March 27, 2015 12:16 PM
AbstractMost current therapies for the autoimmune diseases systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), as well as many of the drugs in the therapeutic pipeline, reduce the autoimmune inflammatory process but lead to a general...
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Scooped by Gilbert C FAURE
March 22, 2015 5:20 AM
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A new approach for diagnosing type 1 diabetes in autoantibody-posit... - PubMed - NCBI

From www.ncbi.nlm.nih.gov - March 19, 2015 4:02 PM
Diabetes Care. 2015 Feb;38(2):271-6. doi: 10.2337/dc14-1813. Epub 2014 Dec 17. Research Support, N.I.H., Extramural
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Scooped by Gilbert C FAURE
March 12, 2015 3:44 PM
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Examination of autoantibody status and clinical features that associate with cancer risk and cancer-associated scleroderma - Shah - Arthritis & Rheumatology - Wiley Online Library

Examination of autoantibody status and clinical features that associate with cancer risk and cancer-associated scleroderma - Shah - Arthritis & Rheumatology - Wiley Online Library | AUTOIMMUNITY | Scoop.it
From onlinelibrary.wiley.com - March 6, 2015 10:10 AM
Examination of autoantibody status & clinical feats that associate w/ cancer risk & cancer-assoc #scleroderma: http://t.co/MYEqbWhd9F
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Scooped by Gilbert C FAURE
March 1, 2015 2:39 PM
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PEPperPRINT: New Application Note: Human Autoantibody Screening with the PEPperCHIP® Autoimmune Epitope Microarray 2.0

PEPperPRINT: New Application Note: Human Autoantibody Screening with the PEPperCHIP® Autoimmune Epitope Microarray 2.0 | AUTOIMMUNITY | Scoop.it
From www.pepperprint.com - February 22, 2015 6:52 AM
#Autoantibody #Screening: New application note about the #Autoimmune #Epitope #Microarray 2.0 http://t.co/LKrdQdBgoC http://t.co/57ZLgcGYi5
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Scooped by Gilbert C FAURE
February 20, 2015 2:57 PM
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Angiotensin II type 1 receptor autoantibody as a novel regul... : Journal of Hypertension

From journals.lww.com - February 19, 2015 10:51 AM
Background: Preeclamptic women and their infants have significant morbidity and mortality worldwide.
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Scooped by Gilbert C FAURE
February 16, 2015 1:21 PM
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Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer

From www.pnas.org - February 9, 2015 4:10 PM
An autoantibody marker to detect aggressive prostate #cancer? http://t.co/f3WQ9N9qjQ @PNASNews #indivmed http://t.co/KbSyKMcnDt
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Gilbert C FAURE's insight:

In this report, serum antibodies to alpha-2–Heremans–Schmidt glycoprotein (fetuin-A) were demonstrated to display increased reactivity with concomitant development of metastatic castrate-resistant disease in a large cohort of prostate cancer patients.

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Scooped by Gilbert C FAURE
February 16, 2015 1:19 PM
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Discovery and horizontal follow-up of an autoantibody signature in ... - PubMed - NCBI

From www.ncbi.nlm.nih.gov - February 13, 2015 7:54 AM
Proc Natl Acad Sci U S A. 2015 Feb 9. pii: 201500097. [Epub ahead of print]
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Suggested by Société Francaise d'Immunologie
February 10, 2015 1:59 PM
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JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells [AUTOIMMUNITY]

From www.jimmunol.org - February 6, 2015 4:01 PM
Peritoneal B1a cells expressing CD5 and CD11b generate autoantibody-producing precursors in autoimmune-prone mice.
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Scooped by Gilbert C FAURE
February 3, 2015 2:05 PM
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Finding the elusive and causative autoantibody: An atypical case of autoimmune hemolytic anemia - Fetzko - 2015 - Clinical Case Reports - Wiley Online Library

Finding the elusive and causative autoantibody: An atypical case of autoimmune hemolytic anemia - Fetzko - 2015 - Clinical Case Reports - Wiley Online Library | AUTOIMMUNITY | Scoop.it
From onlinelibrary.wiley.com - February 2, 2015 5:05 AM
Finding the elusive and causative autoantibody: An atypical case of autoimmune hemolytic anemia http://t.co/P8SQz3QTki
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Suggested by Société Francaise d'Immunologie
January 18, 2015 12:15 PM
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Cutting Edge: AIM2 and Endosomal TLRs Differentially Regulate Arthritis and Autoantibody Production in DNase II-Deficient Mice [CUTTING EDGE]

From www.jimmunol.org - January 16, 2015 4:01 PM
Innate immune pattern recognition receptors sense nucleic acids from microbes and orchestrate cytokine production to resolve infection. Inappropriate recognition of host nucleic acids also results in autoimmune disease.
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Scooped by Gilbert C FAURE
January 17, 2015 2:12 PM
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Autoimmune hepatitis in the Alaska Native population: autoantibody profile and HLA associations.

Autoimmune hepatitis in the Alaska Native population: autoantibody profile and HLA associations. | AUTOIMMUNITY | Scoop.it
From www.pubfacts.com - January 16, 2015 7:25 PM
Autoimmune hepatitis in the Alaska Native population: autoantibody profile and HLA associations. http://t.co/pzju7glOI3
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Scooped by Gilbert C FAURE
April 11, 2015 4:35 AM
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EUROPattern Suite technology for computer-aided immunofluorescence microscopy in autoantibody diagnostics. - PubMed - NCBI

EUROPattern Suite technology for computer-aided immunofluorescence microscopy in autoantibody diagnostics. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
From www.ncbi.nlm.nih.gov - April 8, 2015 3:36 AM
Lupus. 2015 Apr;24(4-5):516-29. doi: 10.1177/0961203314559635.
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Scooped by Gilbert C FAURE
April 2, 2015 2:43 AM
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Infectious and Autoantibody-Associated Encephalitis: Clinical Features and Long-term Outcome

Infectious and Autoantibody-Associated Encephalitis: Clinical Features and Long-term Outcome | AUTOIMMUNITY | Scoop.it
From pediatrics.aappublications.org - April 1, 2015 4:43 AM
Infectious and Autoantibody-Associated Encephalitis: Clinical Features and Long-term Outcome http://t.co/XwDv9mmA0F
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Scooped by Gilbert C FAURE
March 28, 2015 8:33 AM
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Neuronal Na+/K+ ATPase is an autoantibody target in paraneoplastic neurologic syndrome. - PubMed - NCBI

Neuronal Na+/K+ ATPase is an autoantibody target in paraneoplastic neurologic syndrome. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
From www.ncbi.nlm.nih.gov - March 27, 2015 12:12 PM
Neurology. 2015 Mar 25. pii: 10.1212/WNL.0000000000001493. [Epub ahead of print]
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Scooped by Gilbert C FAURE
March 12, 2015 3:44 PM
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Frontiers | The uses and misuses of multiplex autoantibody assays in systemic autoimmune rheumatic diseases | B Cell Biology

From journal.frontiersin.org - March 6, 2015 7:09 AM
Autoantibodies to cellular constituents are the serological hallmark in systemic autoimmune rheumatic diseases 1. They are often associated with certain diagnosis, clinical features, or disease act...
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Gilbert C FAURE's insight:

Multiplex immunoassays for autoantibodies differ significantly depending on the manufacturer or kits and do not always show the intended specificity and sensitivity. These assays should be validated against a standard assay before releasing to the market or using in research to avoid confusions among clinicians and researchers. Postmarket evaluation of these technologies including systematic evaluation and standardization of assays are warranted.

 nice synthesis

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Scooped by Gilbert C FAURE
March 9, 2015 3:36 PM
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Autoantibody response against NALP5/MATER in primary ovarian insufficiency and in autoimmune Addison's disease: The Journal of Clinical Endocrinology & Metabolism: Vol 0, No 0

Autoantibody response against NALP5/MATER in primary ovarian insufficiency and in autoimmune Addison's disease: The Journal of Clinical Endocrinology & Metabolism: Vol 0, No 0 | AUTOIMMUNITY | Scoop.it
From press.endocrine.org - March 9, 2015 3:57 AM
Autoantibody response against NALP5/MATER in primary ovarian insufficiency - interesting new study inn JCEM http://t.co/fW3hTCEW11
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Scooped by Gilbert C FAURE
March 1, 2015 2:32 PM
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Predicting Type 1 Diabetes Development in Young Children - Endocrinology Advisor

Predicting Type 1 Diabetes Development in Young Children - Endocrinology Advisor | AUTOIMMUNITY | Scoop.it
From www.endocrinologyadvisor.com - February 26, 2015 10:45 PM
Measuring autoantibodies in the blood may indicate whether the immune system has begun to attack its own insulin cells.
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Gilbert C FAURE's insight:

The new findings from the NIH-funded study, which were recently published in Diabetologia, suggest three ways of predicting development of type 1 diabetes.

If the autoantibody first discovered attacks insulin (IAA). In the study as a whole, this occurred by age 1 year. Dr. Lernmark noted in the release that if a second autoantibody is detected, the person may develop diabetes but perhaps not for 20 years.If the first autoantibody targets GAD65 (GADA), a protein inside the insulin-producing cells. This was most common at age 2 years in the study.If both autoantibodies are first found together. According to Dr. Lernmark, 40% of these children in the TEDDY study had already developed diabetes.

In the study, participants were enrolled as infants and underwent quarterly standardized autoantibody assessments for the first 4 years of life and semi-annually thereafter.

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Scooped by Gilbert C FAURE
February 16, 2015 1:26 PM
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FOXP3 autoantibody as a potential early prognostic serum biomarker ... - PubMed - NCBI

From www.ncbi.nlm.nih.gov - February 16, 2015 1:26 PM
Int J Clin Oncol. 2015 Feb 15. [Epub ahead of print]
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Scooped by Gilbert C FAURE
February 16, 2015 1:19 PM
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MHC associations with clinical and autoantibody manifestations in E... - PubMed - NCBI

From www.ncbi.nlm.nih.gov - February 13, 2015 6:14 AM
Genes Immun. 2014 Apr;15(4):210-7. doi: 10.1038/gene.2014.6. Epub 2014 Mar 6. Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Scooped by Gilbert C FAURE
February 12, 2015 4:08 PM
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The major autoantibody epitope on Factor H in atypical Hemolytic Uremic Syndrome is structurally different from its homologous site in Factor H related protein 1 supporting a novel model for induct...

The major autoantibody epitope on Factor H in atypical Hemolytic Uremic Syndrome is structurally different from its homologous site in Factor H related protein 1 supporting a novel model for induct... | AUTOIMMUNITY | Scoop.it
From www.mendeley.com - February 12, 2015 7:09 AM
Authors: Arnab Bhattacharjee, Stefanie Reuter, Eszter Trojnár, Robert Kolodziejczyk, Harald Seeberger, Satu Hyvärinen, Barbara Uzonyi, Ágnes Szilágyi, Zoltán Prohászka, Adrian Goldman, Mihály Józsi, T Sakari Jokiranta, Discipline: Medicine, Type: ...
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Scooped by Gilbert C FAURE
February 4, 2015 1:36 PM
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Macrophage activation syndrome in a newborn infant born to a mother with ... - Nature.com

From news.google.com - January 28, 2015 1:26 AM
Macrophage activation syndrome in a newborn infant born to a mother with ...
Nature.com
On the basis of her test results the mother's autoantibody screening was repeated, and the anti-SSA/Ro antibody was positive, identical to her baby's.
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Scooped by Gilbert C FAURE
January 26, 2015 1:56 PM
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Graphene Oxide Interfaces in Serum Based Autoantibody Quantification - Analytical Chemistry (ACS Publications)

Graphene Oxide Interfaces in Serum Based Autoantibody Quantification - Analytical Chemistry (ACS Publications) | AUTOIMMUNITY | Scoop.it
From pubs.acs.org - January 20, 2015 4:31 PM
Graphene oxide interfaces in serum based autoantibody quantification http://t.co/r2oiKNGBIN
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Scooped by Gilbert C FAURE
January 17, 2015 2:13 PM
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Anti IFN-gamma autoantibody associated with adult-onset immunodeficiency

Anti IFN-gamma autoantibody associated with adult-onset immunodeficiency | AUTOIMMUNITY | Scoop.it
From pathtocourage.relationalminutetowinit.com - January 15, 2015 11:22 PM
Anti IFN-gamma autoantibody associated with adult-onset immunodeficiency

Presented by Suda Punrin, MD.
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