Hésitations Vaccinales: Observatoire HESIVAXs

🎥 #OncotargetShort:
Abstract #video about this #casereport recently #published in Volume 17, titled "Exploring the potential link between mRNA COVID-19 vaccinations and cancer: A case report with a review of haematopoietic malignancies with insights into pathogenic mechanisms."

🔗 https://lnkd.in/eAwHNfGE

#cancer #TrendingWithImpact #COVID19 #vaccination #research #openaccess #openscience #peerreview #journal #publishing #meded

In our journal club today, Adeline Tinessia presented this amazing paper on - "Associations between parental vaccine hesitancy, religion-based vaccine hesitancy, and childhood full vaccination in a cross-sectional study in Aceh, Indonesia, 2023" https://lnkd.in/g8UWbs9f

💡 paper provides a deeper look into teasing out religion based hesitancy to general hesitancy through a large survey of almost 1700 people. A few years old paper but worth reading if you're interested in immunisation in Indonesia or hesitancy. Not many studies look at this topic at a sub-national level, an area where there have been ongoing measles & polio outbreaks.

🎯 Addy's conclusion - access based strategies alone won't help the coverage gap. Engaging with religious leaders is important in such settings.

🛣watch out for findings from her PhD looking at the role of religious leaders in immunisation.

Vaccine hesitancy doesn’t start in the community. It starts earlier.

A new study by Francis Drobniewski and Marcia Ashmi shows that even healthcare workers (the ones we trust most) can be hesitant about vaccination.

Despite their key role in building public trust, vaccination uptake among healthcare professionals remains suboptimal. For example, recent data show influenza vaccination rates of around 40–50% among frontline HCWs in England.

This study argues that addressing vaccine hesitancy must begin during training, not only after qualification. Promoting awareness of real (rather than perceived) risks, and reinforcing the benefits of vaccination early on, can help shape long-term behaviours and improve uptake.

Strengthening confidence among healthcare workers is essential, not only for their own protection but also to support informed decisions within the wider community.

👏 Congratulations to the authors on this important publication.
Read more at the link: https://lnkd.in/gFH9UfiJ
For the full publication go to: https://lnkd.in/gsGbdXa4

EuCARE continues to contribute to advancing knowledge and addressing key public health challenges.

#EuCARE #vaccine #healthcare #hesitancy

Really excited to share that the first article from my DPhil is now published in BMJ Public Health! 🎉

This paper presents findings from the NAVIGATE study—a mixed-methods analysis (survey n=395; interviews n=15) examining the acceptability and implementation of a gonorrhoea vaccination programme among UK sexual health service users.

Against the backdrop of rising antimicrobial-resistant Neisseria gonorrhoeae, we found high overall support for vaccination (>90%), largely driven by concern about AMR and strong trust in UK regulatory systems. At the same time, the study highlights key implementation challenges: stigma in healthcare settings, structural barriers (including cost and access), and the need for transparent communication—particularly around partial vaccine effectiveness.

Importantly, the findings emphasise that uptake will depend on how vaccine programmes are delivered: low-barrier access, trusted settings, and peer-led outreach emerged as critical components. Please do give it a read!

🔗 https://lnkd.in/eVmvTKC3

Sophia Wilkinson | Dr Sam M. | Samantha Vanderslott | Sir Andrew Pollard | Katrina Pollock | University of Oxford | Oxford University Department of Paediatrics | Reuben College, University of Oxford | BMJ | NIHR Oxford Biomedical Research Centre | 12 comments on LinkedIn

OPEN-ACCESS - No paywall, free to download

The authors of this study investigated why healthcare interventions rarely work the same way in different countries - in particular, looking at an Australian vaccine communication intervention to determine whether it would work in Canada.

By analysing the behaviour change frameworks, the authors identified that some important barriers in the Canadian context were not addressed, including social influences and local concerns around vaccination. This kind of analysis helps researchers adapt interventions before implementing them, improving their chances of success.

Download the full-text article here: https://lnkd.in/gZedTJQz
Andrea Patey Dalhousie University IWK Health María Castrellón Pardo Monica Surti Medea Myers-Stewart, MPH Jessica Kaufman, PhD Murdoch Children's Research Institute (MCRI) University of Melbourne Prof Margie Danchin The Royal Children's Hospital Maoliosa (Mo) Donald Eliana Castillo Craig Lockwood Dr Alana Delaforce, PhD, RN Catherine Willinsky Rozmin Punjani MBA, BSN, BA, CCMC, CPST Sue Kerns, PhD Ahmad Firas Khalid, MD, PhD, MMgmt, MEd, GradCertPHM Julia Moore Annemarie Edwards Evangeline Danseco Karri Venn Kara DeCorby Kelly Aschbrenner Onil Bhattacharyya Priscilla Medeiros Annette Boaz Joanne Yoong Cynthia Vinson Stephen Gentles, MSc, PhD Edmond Ramly Mary Abdo Duncan C. Meyers, PhD Jane Stafford Jacquie Brown, MES,RSW Robyn Traynor Arlene Bierman Robert Franks Jennifer N. Hill

Sometimes, someone might want to fully read a paper before making claims which have no relevance whatsoever. Why? Well, let’s look at the conclusion of the authors Hulscher refers, only to see how much he doubles down on nothing :  « we have found residues of the vaccine RNA via RNAScope technique but no viral RNA in two individual spike protein samples. No correlation was seen between spike protein or modRNA detection in the placentas with the medical outcome of mother and child due to our inclusion criteria and the small cohort. »

"A research letter published yesterday in JAMA Pediatrics suggests that while most teens seen in Children’s Hospital of Philadelphia (CHOP) primary care clinics completed the human papillomavirus (HPV) vaccine series before becoming sexually active, 12% had not received any doses, representing a missed opportunity for cancer prevention.

The researchers analyzed the electronic health records (EHR) from 9,491 patients aged 13 to 18 years seen at 31 CHOP-affiliated primary care practices from September 2023 to September 2025. The teens had reported sexual activity on the Adolescent Health Questionnaire.

The average patient age was 17.0 years, 47% were girls, 40% were Black, 40% were White, 9% were Hispanic, 11% were another race, 44% were Medicaid-insured, and 33% lived in very low Child Opportunity Index neighborhoods."

🤱 For many parents, understanding HPV and the value of vaccination can be daunting. This study shows that interacting with a specially designed AI chatbot helped parents better understand HPV, feel more confident about vaccination, and take action for their daughters’ health.

Tools that support caregivers with clear, accessible information can make a real difference in vaccine decisions.


#CaregiverSupport #VaccineEducation #ParentVoices

📌 https://lnkd.in/gWZU-Rc5

 

Très heureux de voir ce papier écrit avec Jeremy Ward (Cermes3) et Benoit Giry (Arènes UMR6051) paraitre dans Sociology of Health and Illness Journal.
On se penche sur les participations ordinaires aux politiques publiques (ici de santé). Entre l'engagement institutionnel (associations, mouvements, partis...) et le simple respect des politiques publiques, qui sont celles et ceux qui s'engagent de manière "ordinaire" pour convaincre leur entourage de (ne pas) se faire vacciner pendant la crise du Covid19 ?
On y parle compétence politique et rapport au politique.

Dispo ici OpenAccess : https://lnkd.in/e-g4CC4V

"“Why are there some vaccines that use aluminum and some that don’t?” asked Kate from Maryland. “Is there a biological reason why it’s needed in some cases and not others?”
Yes, there is. Vaccines made from live, weakened viruses generally do not require aluminum because the virus itself replicates just enough to provoke a strong immune response. Examples include the vaccines against rotavirus; measles, mumps and rubella (MMR); chicken pox; and the oral polio vaccine.

By contrast, many other vaccines contain only a piece of the virus or bacteria, often a purified protein or sugar from its outer surface. That component is what teaches the immune system to recognize and fight the real pathogen. Because these vaccines do not contain a live organism, the immune response they trigger can be weaker. Aluminum helps amplify that response. Scientists call such enhancing ingredients “adjuvants.”
Vaccines that protect against multiple diseases in a single shot often require less adjuvant than single-component vaccines. That is because each component provides its own stimulus to the immune system. When several antigens are combined, the overall immune activation is greater, so less additional boosting is needed.

A recent JAMA analysis illustrates this point. One dose of the combination vaccine Pentacel, which protects against diphtheria, tetanus, whooping cough, polio and Haemophilus influenzae type B (HiB), contains about 0.33 milligrams of aluminum. By contrast, administering comparable vaccines separately can total up to 0.725 milligrams.
This is worth emphasizing because administration officials have advocated separating combination vaccines. Doing so would actually increase aluminum exposure while also adding the burden of more injections, more clinic visits and higher health care costs."
https://wapo.st/3NaWBQu

📢 What is the economic case for introducing HPV, pneumococcal, and rotavirus vaccines in Pacific island states? 📢

A new modelling study published in PLOS Medicine evaluates the cost-effectiveness and budget impact of simultaneously introducing HPV, PCV, and rotavirus vaccines in Samoa, Tonga, Tuvalu, and Vanuatu.

Using the UNIVAC model, the study estimates:
💉 1,015 lives saved across vaccinated cohorts
🏥 Significant reductions in outpatient visits and hospitalisations
🔎 Cost per DALY averted below 1× GDP per capita in all four countries at PAHO prices
💵 Improved cost-effectiveness with lower-priced vaccines
🚨 Immunisation budgets would need to increase by 359%–1,368%

The analysis suggests that introducing all three vaccines represents good value for money, but would require substantial increases in immunisation budgets, underscoring the importance of affordable vaccine pricing in a context of increasingly constrained fiscal space.

🔗 Read more here: https://lnkd.in/eA2NfGjF

Authors: Natalie Carvalho, Emma Watts, Tori Oliver, Andrew Clark, Murat Hakan Ozturk, Siale Akauola, Clare Whelan, Take Naseri , Kylie Jenkins, Inez Mikkelsen-Lopez, Ki Fung Kelvin Lam, Rommel Rabanal, Ross McLeod, Mark Jit, Fiona Russell.

Exposure to health misinformation on social media across key health domains: a systematic review and meta-analysis of survey-based studies (BMC Public Health, Springer Nature Link):

https://lnkd.in/dHb5B_ed

Glimpse: Individual-level exposure to health misinformation on social media in a variety of domains, such as COVID-19, vaccination, cancer, and oral health, is examined in this systematic review and meta-analysis. The analysis, which synthesizes eight observational studies (N = 22,780), reveals that exposure is widespread but highly variable, with extreme heterogeneity and a pooled estimate of 59%. While platform effects vary by context rather than serving as consistent drivers, higher exposure is consistently linked to younger age, lower health or digital literacy, and minority status. The study comes to the conclusion that exposure to health misinformation should be viewed as domain- and environment-specific, and that rather than making broad generalizations, the results should be used to guide focused, context-sensitive public health interventions.

I’m delighted to share our latest paper examining factors influencing vaccine uptake in culturally and linguistically diverse communities in Australia!

This review highlights that trust in healthcare providers and community leaders is central, alongside the need to address structural barriers and improve access to information and services.

Culturally responsive engagement, co-design, and coordinated approaches are key to improving vaccination equity.

https://lnkd.in/eViccvYm

#Vaccination #HealthEquity #CALD #Immunisation #CulturalSafety

🎯 Single-dose HPV vaccination: What’s holding countries back, and what’s pushing them forward?

Understanding what drives—or slows—national decisions to adopt single-dose HPV vaccine schedules is critical as updated evidence and WHO recommendations create new opportunities for coverage expansion.

A recent study from reserachers at the Johns Hopkins Bloomberg School of Public Health synthesizes insights from immunization stakeholders across 19 LMICs on factors influencing HPV schedule decision-making.

Key insights:
📈 Stakeholders value single-dose schedules for higher completion, broader coverage, and reduced delivery costs
📦 Simplified schedules help optimise stock and operational capacity, particularly where supply constraints persist
🚧 Barriers include limited localized long-term evidence and the resources required to adjust existing programmes

👉 Learn more about the study here: https://lnkd.in/eN_f46f8

Authors:
Erica N. Rosser, Ishani Sheth, Megan Wysong, MPH, Sunny Roy, Casey Geddes, Rupali Limaye, PhD, Joseph (Greg) Rosen

💉 What does it take to make vaccine manufacturing in LMICs economically sustainable?

A new Vaccine paper from the World Health Organization, Medicines Patent Pool, and The University of Sheffield unpacks what it really takes for LMIC vaccine manufacturing to work—economically and long-term.

What matters most:
💰 High upfront costs + uncertain demand make manufacturing risky
🏛️ Strong government backing is essential early on
🔬 Long-term success depends on strong science ecosystems
🌍 Regional approaches (markets + regulation) are key to scale
📈 Sustained demand beyond pandemics is critical to keep production viable

Read more here: 👉 https://lnkd.in/e-uG5g3J

Authors: Matthias Helble, Claudia Nannei, martin friede, Martin Nicholson

#GetTheMessage

Misinformation about mRNA vaccines is shaping legislation and policy. Today, my colleagues and I respond to the false narratives that have flooded social media and are negatively impacting health care.

"mRNA COVID-19 Vaccines: Science vs. Misinformation" — now published in RNA Journal.

A comprehensive, peer-reviewed response to the most persistent false claims. DNA alteration. Infertility. Microchips. "Gene therapy." Shedding. We address them all—with evidence, citations, and the biology.

Authored by researchers and industry leaders from the Alliance for mRNA Medicines, with over 100 references to peer-reviewed literature.

We wrote this for healthcare providers, policymakers, educators, journalists—anyone who needs a rigorous, citable resource to push back against false narratives.

https://lnkd.in/er5vjr_k

It's open access. Anyone can read it.

#mRNA #GetTheMessage #Science #PublicHealth #Vaccines #HHS, Alliance for mRNA Medicines

For millennia, humans have sought and found purpose, solace, values, understanding, and fellowship in religious practices. Buddhist nuns performed variolation against smallpox over 1000 years ago. Since Jenner developed vaccination against smallpox in 1796, some people have objected to and declined …

I loved working on this interesting paper with my superstar colleague Hang Duong