Hésitations Vaccinales: Observatoire HESIVAXs

📄 A new study explores the relationship between immunization budgets and vaccine coverage across 9 antigens in 19 low- and lower-middle-income countries analyzed data from UNICEF’s newly released Global Immunization Budget Database for 2021-2024.

📈 A one percentage point increase in the immunization budget was associated with a 0.42% increase in DTP1 coverage growth rate when controlling the years. Other antigens, including DTP3, BCG, MCV1, POL3, IPV1, and PCV3, also showed positive but non-significant trends.

💡The author, Hao-Kai TSENG, highlights that the Global Immunization Budget Database is a breakthrough in immunization economics, leveraging AI to extract and categorize scattered line items from national budget documents, and providing an early outlook into governmental priorities.

Find out more here: https://lnkd.in/e878mR9n

📄 A new study in Vaccine finds that giving 13-valent pneumococcal conjugate vaccine and rotavirus vaccine during the same visit is as safe as giving them separately and lowers overall costs.

Partial-dose concurrent vaccination was found to be cost-effective, with total costs reduced by 2.29%, 2.20%, and 1.07% for co-administering 1, 2, and 3 doses, respectively, compared to the current separate administration schedule, driven largely by savings in indirect and non-medical costs (e.g., fewer clinic trips).

🔗 Read the full findings: https://lnkd.in/eGrtHnNy

📄 A new study examines the landscape of vaccine financing and health economics capacity across countries in the Eastern Mediterranean region, highlighting gaps in sustainable financing, limited local capacity for economic evaluation, and reliance on external donors.

💡 The study emphasizes the importance of strengthening domestic financing mechanisms and institutional capacity to support evidence-informed vaccine policy over the long term, and argues for increased investments in health economics training, stronger governmental commitment to routine immunization budgets, and better coordination between national agencies, donors, and technical partners.

Read the full article: https://lnkd.in/e6eCVcSw

Authors: Dr Palwasha Anwari, Gerald Sume, Wedyan Meshreky, Nathalie Vande Maele, So Yoon Sim, Diana K., Philipp Lambach, Maarten Jansen, Raymond Hutubessy, Quamrul Hassan. World Health Organization, UNICEF

Dear Editor Vaccinations have been one of the most important public health measures for preventing poor health, saving millions of lives worldwide every year.(1-3) A recent modelling study estimated that since 1974 vaccines against 14 common pathogens have saved 154 million lives, 95% of these in...

While the post might have been removed by LinkedIn, the facts do remain. First, mRNA are NOT gene therapy despite the claims of anti-vaccine organizations. Second, SARS-CoV-2 can result in several cardiovascular events, both during acute infection and as a late complication. COVID-19 infection poses a greater cardiovascular risk than the vaccines, with studies showing infection increases the risk of heart attack, stroke, and blood clots, while vaccine-related cardiovascular risks, such as myocarditis and pericarditis, are rare and generally less severe. Excess cardiovascular deaths during the pandemic are already being seen in many countries In 2020, this observation was thought to be due to decreased access to care for patients with CVD, but it is now apparent that deaths attributed to cardiovascular causes during the pandemic likely have COVID-19 as a contributing factor. The cumulative evidence identified in this review suggests that the COVID-19 pandemic has resulted in a substantial excess acute burden of CVD. There may also be an excess chronic burden of disease that impacts populations and health systems, even if long-term cardiovascular effects only occur in a small proportion of patients. With more than 610 million people affected globally and no end in sight to the pandemic, this burden of CVD will likely be felt in every nation’s health system and economy for many years.

https://lnkd.in/eUE4enc2

Novel approaches for anti-vaxxers: creating their own journal with biased editorial boards, that would publish anything and everything to push their narrative against COVID vaccines. The latest kid on the block: the Journal of Independent Medicine.

We had the International Journal of Vaccine Theory, Practice and Research, clearly identified as an anti-vaxxer journal by Wikipedia. There is also Science, Public Health Policy and the Law. If you look at these journals, you will see that their editorial boards are composed of the who’s who of anti-vaxxer pushers, with editors in chief having no vaccine expertise nor experience.

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We have seen anti-vaxxers pushing a false theory that declining birth rates were caused by COVID vaccines. Well, the IMF produced this analysis showing that such have been declining since the mid 60s with alarming rates since the 90s. As you see, timing wise all of this has nothing too do with COVID vaccines, it started much earlier and it is related to socioeconomic reasons .

Jusqu'à présent les délires antivax et les discours pseudo-scientifiques de Jean-Marc Sabatier, le pape de la vitamine D et fabricant de potions à l'Artemisia goût pastis, auteur de torchons imprimés sur papier Moltonel épaisseur triple et, très accessoirement directeur de recherches au CNRS et à l'Aix-Marseille Université où un réfugié scientifique américain doit se demander ce qu'il fait là, surtout s'il a rencontré Rantanplan Chabrière, auraient eu plutôt tendance à me faire sourire faisant abstraction de la stupidité des propos proférés et de leurs conséquences sanitaires.

Mais, depuis que Didou la Fraude aurait presque, en dehors de quelques pénibles rodomontades sur X/Twitter, disparu des radars, mon Jean-Marcounet montre un regain d'activité complotiste et se radicalise dangereusement.

Celui-ci cosigne un "article" pseudo-scientifique publié par la revue Coronaviruses du groupe Bentham Science Publishers, India dont il est encore le directeur du comité éditorial alors qu'il n'est lui-même nullement virologue...
Dans ce torchon, Jean-Marc et ses potes inconnus au bataillon "pensent" que la protéine Spike du SARS-CoV-2 et surtout celle codée par l'ARNm des vaccins anti-#Covid19 pourrait provoquer et/ou aggraver une sclérose latérale amyotrophique (SLA) ou maladie de Charcot en interférant le système rénine-angiotensine qu'il affectionne tout particulièrement le Jean-Marcounet.

Depuis plusieurs mois, Sabatier tire en toute impunité, malgré les alertes au CNRS, à son directeur Antoine Petit et à Eric Berton, les sonnettes d'alarme catastrophistes et sans aucun fondement scientifique valable. Quand les vaccins à ARNm ne provoquent pas, selon lui, une infertilité, ceux utilisés chez les canards d'élevage contamineraient les humains en cas d'ingestion de foie gras, et les vaccins auto-amplifiants auraient été mis au point en vue de dépeupler massivement la Terre (Steve Pascolo doit avoir du mal à s'en remettre).

"Guest star" des webTV d'extrême-extrême droite, Jean-Marcounet ne cache plus ses accointances douteuses avec la lie de l'humanité et sera présent comme vedette aux "Assises de la Souveraineté" en septembre prochain, évènement-phare du groupuscule collaborationniste pro-Poutine les Patri-Chiottes où il se verra interviewé par le glorieux mono-parrainé Florian Philippot-de-Chambre devant une foule clairsemée de vieillards au stade avancé d'Alzheimer et autres têtes pleines d'eau.

Après l'annulation d'une conférence antivax à l'Assemblée nationale provoquant la sainte colère de son grand ami Nicolas Ducon-Gnangnan, l'antisémite François Cotard, grand admirateur, tentera de maintenir en novembre prochian une "Journée Sabatier" dans la bonne Ville de Montfermeil dont le maire, Xavier Lemoine, vice-président du parti hyper-catho homophobe de Christine Boutin est un antivax notoire qualifiant les vaccins à ARNm de "thérapie génique".

Dites Yannick NEUDER, vous allez observer encore longtemps en attendant la prochaine motion de censure ? | 13 comments on LinkedIn

📄 A new modelling study has found that bacterial vaccines could potentially avert up to US$283 billion in economic losses through reducing hospital costs and productivity losses from antibiotic-resistant infections, highlighting their role in combating antimicrobial resistance.

📄 Read the full findings: https://lnkd.in/eprGmizQ

Authors: Nichola Naylor, Mateusz Hasso-Agopsowicz, Chaelin Kim, Yixuan Ma, Isabel Frost, Kaja Abbas, Gisela Aguilar, Naomi Fuller, Julie Robotham, Mark Jit. London School of Hygiene and Tropical Medicine, U. of London, World Health Organization, Aquarius Population Health, University of Oxford, UK Health Security Agency

#VaccinesWork #AMR

County-level data indicate a widespread decline in MMR vaccination rates across the U.S., particularly since the COVID-19 pandemic.

https://ja.ma/4dFv829

Why do vaccines seem to work better in rich countries than in poor ones?

Our new Lancet Microbe paper from the HypoVax Global consortium shows that this inequality is real. Children in low and middle income countries often have weaker responses to several common vaccines, and rural communities are hit even harder.

My part was to help track which studies actually shared immunological or omics data. The imbalance was obvious. Almost all public datasets come from Europe and the US, while the places where vaccines perform the worst barely show up.

So we are trying to understand a problem that mainly affects poorer populations using data that come mostly from wealthier ones. HypoVax Global is working to change this by building collaborations, generating better data in underrepresented regions, and giving us a clearer picture of how to reduce this gap.

📄 A new systematic review synthesizes the economic evidence linked to randomized trials of recipient-focused interventions to increase vaccine uptake in and upper-middle and high-income settings.

The review found that cost data and reporting practices are inconsistent, limiting comparability and decision usefulness. The authors call for routine, standardized collection and transparent reporting of costs alongside effectiveness in future RCTs so policymakers can judge not only what works but what is most cost-effective

🔗 Read the full article: https://lnkd.in/epu8URQD

Ah don’t we love anti-vaxxers… 6 days again I posted this critical appraisal of something #nicolashulscher posted. Another post of misinformation and lies. One that someone tried to have removed for pretending that debunking falsehoods, misinformation, misquoting, extending beyond what papers are saying and lies. In this case, the four papers were not studies, as these were opinion pieces. Some of such were flagged as misinformation, even retracted. # of these came from Peter McCullough, the world’s most retracted cardiologist on COVID papers. Some of these were flawed in design and data in claims of either COVID deaths, either excess ones (not proven) or autopsies where original authors never linked these to COVID vaccines, unlike the claims #nicolashulscher made and got retraction for such… My post is back after 6 days showing that truth always wins. And that McCullough Foundation is wrong…

Public-health officials in Kennedy’s position rarely request that studies be retracted, says Ivan Oransky, a specialist in academic publishing and co-founder of the media organization Retraction Watch. Through this request, “Secretary Kennedy has demonstrated that he wants the scientific literature to bend to his will”, says Oransky.

A Huge Danish Study Found No Link Between Vaccine Aluminum and Autism
Now RFK Jr. is Pressuring the Journal to Retract It

RFK Jr's ever-evolving claims of a link between vaccines and autism keep getting contradicted by data, and it's making him really mad. First, he embraced Wakefield's claim that MMR caused autism, only to face multiple large studies showing no association between MMR and autism. Then, he started saying the real culprit was thimerosal (though MMR never contained thimerosal), prompting large studies that showed no association between thimerosal and autism. Still, thimerosal was dropped from virtually all childhood vaccines >30 years ago in Sweden, and >20 years ago in US, but neither country saw autism diagnoses drop. Undaunted, he started claiming that aluminum adjuvants (used in vaccines since the 1930s) were the REAL culprits, despite the fact that the amounts of aluminum in childhood vaccines are so small and absorbed so slowly, that a study of preterm infants found NO increase in infants' serum aluminum levels after receiving multiple aluminum adjuvanted vaccines.

Then, the coup de grace: Last month, a study of 1.2 million Danish children spanning 21 years found zero association between aluminum adjuvanted vaccines and autism (or any of the other serious harms claimed by RFK Jr. and his acolytes). Since then, RFK Jr. has desperately tried to discredit the study, and (of course) launched personal attacks on the authors' integrity, calling the research "a deceitful propaganda stunt by the pharmaceutical industry," despite the fact that the study received no industry funding, but was instead funded by the Danish government.

And now, despite his supposed opposition to "censorship," Kennedy is trying to wield the power of the Federal government to suppress research findings he doesn't like, pressuring Annals of Internal Medicine to retract the study.

In 2023, RFK Jr. said the following: "A government that can censor its critics has license for every atrocity. It is the beginning of totalitarianism.”

Well said.

Sources in Comments. | 27 comments on LinkedIn

BMJ Highlights My Research on Barriers to Childhood Vaccination

Despite growing concern over falling vaccination rates, much of the UK evidence base continues to focus on changing minds rather than improving access—an imbalance highlighted in my recent review: https://lnkd.in/eG37bAJi.

That insight led to a longitudinal study, now featured in The BMJ, which found that logistical barriers — such as difficult booking systems and punitive appointment policies — can make accessing routine vaccinations unnecessarily challenging, even for highly motivated parents.

👩‍🍼 “…if I didn't care that much about getting them, I definitely wouldn't have persevered.” [Evie, wave 1 interview]

Supporting uptake means supporting families—not just with information, but with services that are easy to navigate.

📄 Read the research: https://lnkd.in/gemMVyqg
📰 Read the BMJ feature: https://lnkd.in/e6c8QMdH

Grateful to the participants, co-authors, and funders who made this research possible—and to Emma Wilkinson for the wonderful feature.

Another situation where Physicians for Informed Consent is misleading you and misreading the literature. And clearly shows that they want you and your children dead.
First, the data regarding a potential reduction of risk of lymphoma is controversial as some research suggests a potential link between measles and a reduced risk of certain types of lymphoma. However, this is a complex area with conflicting evidence, and measles infection can also have detrimental effects on individuals with lymphoma, particularly those who are immunocompromised. Gigafact, having analyzed such claim, shows that measles prevention of cancer is not true.
Second, there is data from three measles outbreaks that shows that measles increases the risk of lymphoma:¨above observed rise in measles, as it may not be recent, be related with the reported increase in incidence in young-adult cHL in Connecticut , Israel  and Quebec, such contradicting some data showing a protective effect. The measles virus may indeed be the common contagious agent considered to evoke a late exposure infection and suspected to be a novel cause for cHL. It may also contribute to carcinogenesis in other solid tumors.¨
Third, one should never forget that measles can cause a phenomenon called "immune amnesia," where the virus wipes out some of the immune system's memory, making individuals more susceptible to other infections. This happens because measles infects and kills memory cells, which are crucial for recognizing and fighting off previously encountered pathogens. While the immune system eventually recovers and rebuilds, it can take time, leaving individuals vulnerable for a period after a measles infection. 
And finally, catching measles put you at risk for a delay form of post measles encephalitis. Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, and ultimately fatal disease of the central nervous system that can develop years after a measles infection. It's caused by a persistent, mutated form of the measles virus that can reactivate and attack the brain.

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https://lnkd.in/e9PT2n2U, as

📢 𝗡𝗲𝘄 𝗣𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻: “Pandemic, religion, and vaccination resistance: a multidimensional analysis
of religious communities in Italy”

I am trilled to share with you a new publication with Ricciardi Walter and Maria Rosaria Gualano analysing how religious beliefs and practices influenced vaccine hesitancy during the pandemic and to assess the broader impact on public health outcomes. It also seeks to identify strategies for mitigating conflicts between religious freedoms and public health imperatives in future crises. #vaccine #publichealth #pandemic #health #vaccinehesitancy
https://lnkd.in/dh4bVvBk

🚨 BREAKING: Amyloid Fibrils Found in 3-Year-Old After In-Utero Genetic Countermeasure Exposure

The child was born 1 week after mother’s 2nd dose —no vital signs at birth, required resuscitation, and has been chronically ill since: recurrent infections, multiple surgeries, immune dysfunction.

🔻 At age 3, shows persistent amyloid-like fibrils circulating in blood

🔻 Confirmed by fluorescence microscopy & SEM—not typical clots or plaques

🔻 Fibrils exhibit cross-β sheet binding, prion-like folding, and autofluorescence

"The persistence of amyloidogenic fibrils years after gestational exposure cannot be dismissed by outdated pharmacokinetic assumptions."

https://lnkd.in/gta-sUS9

#MFScholar | 17 comments on LinkedIn

FDA VRBPAC December 11, 2020 Decision on Pfizer Found Invalid

EUA Approval Granted on Incomplete Death Data; Efficacy Not Robust to Missing Data; Trial Progress Delayed to Influence Trump Re-Election Bid

https://lnkd.in/ggJi3qDS