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Scooped by Dr. Stefan Gruenwald
February 7, 2012 2:43 PM
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Entire genome of extinct human Denisovan fossil decoded

Entire genome of extinct human Denisovan fossil decoded | Amazing Science | Scoop.it

The Max Planck Institute for Evolutionary Anthropology, in Leipzig, Germany, has completed the genome sequence of a Denisovan, a representative of an Asian group of extinct humans related to Neandertals.

 

As sequencing source, 10 milligram of a small finger bone fragment that was used, found in the Denisova-Cave in Southern Sibiria.

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Scooped by Dr. Stefan Gruenwald
February 5, 2012 12:14 PM
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IBM Research Creates Microscope With 100 Million Times Finer Resolution Than Current MRI

IBM Research Creates Microscope With 100 Million Times Finer Resolution Than Current MRI | Amazing Science | Scoop.it
IBM Research (NYSE: IBM) scientists, in collaboration with the Center for Probing the Nanoscale at Stanford University, have demonstrated magnetic resonance imaging (MRI) with volume resolution 100 million times finer than conventional MRI.

 

By extending MRI to such fine resolution, the scientists have created a microscope that, with further development, may ultimately be powerful enough to unravel the structure and interactions of proteins, paving the way for new advances in personalized healthcare and targeted medicine. This achievement stands to impact the study of materials – from proteins to integrated circuits – for which a detailed understanding of atomic structure is essential.

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Scooped by Dr. Stefan Gruenwald
February 4, 2012 8:54 PM
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Woman Controls Her Bionic Arm with Thoughts Alone

Woman Controls Her Bionic Arm with Thoughts Alone | Amazing Science | Scoop.it

Claudia Mitchell, who lives in Ellicott City, is the fourth person -- and first woman -- to receive a "bionic" arm, which allows her to control parts of the device by her thoughts alone. The device, designed by physicians and engineers at the Rehabilitation Institute of Chicago, works by detecting the movements of a chest muscle that has been rewired to the stumps of nerves that once went to her now-missing limb.

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Scooped by Dr. Stefan Gruenwald
February 4, 2012 10:29 AM
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Fast, open science publishing for biology and medicine

Fast, open science publishing for biology and medicine | Amazing Science | Scoop.it

The Faculty of 1000 (F1000), in London, has announced an experiment in online science publishing, aimed at sharing research results widely and rapidly, and using open peer review to check postings afterwards. 

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Scooped by Dr. Stefan Gruenwald
February 2, 2012 11:49 AM
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Fast FDA approval for new melanoma drug - new hope for patients

Fast FDA approval for new melanoma drug - new hope for patients | Amazing Science | Scoop.it

The Food and Drug Administration approved an expensive new melanoma drug much faster than expected, giving a boost not only to that drug but also to other experimental products that may offer gene-based personalized medicine. Vemurafenib, with the brand name Zelboraf, treats patients with metastatic melanoma who have a certain genetic mutation called BRAF V600E. The drug inhibits the cancer-spreading action of that particular gene, which is held in about 50 percent of people who have metastatic melanoma. The FDA also approved a test for the genetic mutation BRAF V600E in the patient's tumor.

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Scooped by Dr. Stefan Gruenwald
February 2, 2012 11:43 AM
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Beyond the Genome: Cancer’s Secrets Come Into Sharper Focus

Beyond the Genome: Cancer’s Secrets Come Into Sharper Focus | Amazing Science | Scoop.it

For the last decade cancer research has been guided by a common vision of how a single cell, outcompeting its neighbors, evolves into a malignant tumor. But recent discoveries have been complicating the picture with tangles of new detail. Cancer appears to be even more willful and calculating than previously imagined. Researchers are finding clues that pseudogenes lurking within the so-called "junk" DNA making up over 90% of the total genome play a very important role in cancer.

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 6:57 PM
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Antibodies Found that Prevent Most HIV Strains from Infecting Human Cells

Antibodies Found that Prevent Most HIV Strains from Infecting Human Cells | Amazing Science | Scoop.it

Two potent human antibodies that can stop more than 90 percent of known global HIV strains from infecting human cells in the laboratory have been discovered. These antibodies could be used to design improved HIV vaccines, or could be further developed to prevent or treat HIV infection. Moreover, the method used to find these antibodies could be applied to isolate therapeutic antibodies for other infectious diseases as well.

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 4:02 PM
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Infectious cancer of Tasmanian devil - can it happen to human?

Infectious cancer of Tasmanian devil - can it happen to human? | Amazing Science | Scoop.it

Australia’s Tasmanian devil is more beloved now as it faces extinction from an infectious cancer called Devil facial tumor disease (DFTD). The devils spread it through fighting and mating. The sore tumors grow so large the animal can no longer eat. As of 2006, it was estimated that the Tasmanian Devil could be extinct between 10 and 20 years, with only aproximately 20,000 to 50,000 left. Since there is no cure, it’s a race to keep healthy ones in captivity as the only means to keep DFTD from spreading. It’s still unnerving because no one wants to see a species become potentially extinct in captivity like the thylacine (Tasmanian Tiger) did in 1936.

 

http://en.wikipedia.org/wiki/Devil_facial_tumour_disease

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 2:35 PM
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Gene sequencing X Prize to focus on centenarians

Gene sequencing X Prize to focus on centenarians | Amazing Science | Scoop.it

Prize purse of $10 million: A 30-day contest to launch January 2013 to see which laboratory can accurately and economically sequence 100 human genomes has been tweaked to focus on the genetics of people over the age of 100. While quality, speed and accuracy of the testing is improving, the companies involved, including LIFE, Illumina and Complete Genomics, all have their own standards. http://tinyurl.com/7nlvqs2

 

Videos about Centenarians: http://tinyurl.com/d7ehok7

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 1:57 PM
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Genome of 115 year old woman (supercentenarian) sequenced

Genome of 115 year old woman (supercentenarian) sequenced | Amazing Science | Scoop.it

The entire DNA sequence of a woman who lived to 115 has been pieced together by scientists. The woman, who was the oldest in the world at the time of her death, had the mind of someone decades younger and no signs of dementia. She appeared to have some rare genetic changes in her DNA, some of them might have protected her against dementia and other diseases of later life. The woman was born prematurely and was not expected to survive. But she lived a long and healthy life, and entered a care home at the age of 105. She eventually died from a stomach tumor, having been treated for breast cancer at the age of 100.

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 1:56 AM
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A genetic mutation that makes humans to walk on four limbs

A genetic mutation that makes humans to walk on four limbs | Amazing Science | Scoop.it
A mutated gene may have a role in a rare condition in which humans walk on all fours, researchers say. But precisely how mutations in this gene might stop people from walking upright remains a matter of debate.

 

The existence of quadruped humans was first publicized by a 2006 British television documentary about a Turkish family in which several adults walk on all fours. Those with the condition also suffer from mental retardation and poor balance.


  1. Ozcelik, T. et al. Proc. Natl Acad. Sci. USA 105, 4232–4236 (2008).
  2. Tan, U. Int. J. Neurosci. 116, 1539-1547 (2006). | Article | PubMed |
  3. Humphrey, N., Mundlos, S. & Türkmen, S. Proc. Natl Acad. Sci. USA105, E26 (2008). | Article |
  4. Herz, J., Boycott, K. M. & Parboosingh, J. S. Proc. Natl Acad. Sci. USA105, E25 (2008). | Article |
  5. Türkmen, S. et al. Eur. J. Hum. Genet. doi:10.1038/ejhg.2008.73 (2008).


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Scooped by Dr. Stefan Gruenwald
February 1, 2012 12:59 AM
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6 Big HealthTech Ideas That Will Change Medicine In 2012

6 Big HealthTech Ideas That Will Change Medicine In 2012 | Amazing Science | Scoop.it

In the future we might not prescribe drugs all the time, we might prescribe apps." Predictions for 2012 include AI, big data, 3D printing, social health networks and other new technologies which will lead to better medical care.

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Scooped by Dr. Stefan Gruenwald
January 31, 2012 11:56 PM
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A Doctor in Your Pocket

A Doctor in Your Pocket | Amazing Science | Scoop.it

What will the future of medicine bring? Tiny body monitors, large patient databases and the end of illness. Today, we mostly wait for the body to break before we treat it. In the near future, we will be able to monitor and adjust our health in real time with the help of smartphones, wearable gadgets and many other devices.

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Scooped by Dr. Stefan Gruenwald
February 6, 2012 3:29 PM
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83-Year-Old Woman Gets the World’s First 3D Printed Replacement Jaw

83-Year-Old Woman Gets the World’s First 3D Printed Replacement Jaw | Amazing Science | Scoop.it

An 83 year-old woman in Belgium had a severely infected jawbone, and researchers and doctors were able to replace it with the world's first 3D printed jaw. 3D printing is an innovative process that allows engineers to essentially spray layers of a material (a plastic or metal for instance) on top of each other in order to create a solid 3D form. 3D printing has allowed engineers to make beautiful art pieces, airplanes and food replacements but until now they’ve not been able to create a bone replacement that was ready to be tested in an actual person — though research is underway at many institutes using a plethora of materials.

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Scooped by Dr. Stefan Gruenwald
February 5, 2012 11:20 AM
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UCLA scientists accurately predict age using just a saliva sample

UCLA scientists accurately predict age using just a saliva sample | Amazing Science | Scoop.it

While genes partly shape how our body ages, environmental influences change our DNA as we age - methylation patterns shift as we grow older and contribute to aging-related disease. Using saliva samples contributed by 34 pairs of identical male twins between the ages of 21 and 55, UCLA researchers scoured the men's genomes and identified 88 sites on the DNA that strongly correlated methylation to age. They replicated their findings in a general population of 31 men and 29 women between the ages of 18 and 70.

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Scooped by Dr. Stefan Gruenwald
February 4, 2012 3:04 PM
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Why aren't the oldest living people getting any older?

Why aren't the oldest living people getting any older? | Amazing Science | Scoop.it

Last month, a 114-year-old former schoolteacher from Georgia named Besse Cooper became the world's oldest living person. Her predecessor, Brazil's Maria Gomes Valentim, was 114 when she died. So was the oldest living person before her, and the one before her. In fact, eight of the last nine "world's oldest" titleholders were 114 when they achieved the distinction. Here's the morbid part: All but two were still 114 when they passed it on. Those two? They died at 115. Is 115 years the magical limit?

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Scooped by Dr. Stefan Gruenwald
February 4, 2012 10:17 AM
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DARPA researchers design eye-enhancing virtual reality contact lenses

DARPA researchers design eye-enhancing virtual reality contact lenses | Amazing Science | Scoop.it

Currently being developed by DARPA researchers at Washington-based Innovega iOptiks are contact lenses that enhance normal vision by allowing a wearer to view virtual and augmented reality images without the need for bulky apparatus. Instead of oversized virtual reality helmets, digital images are projected onto tiny full-color displays that are very near the eye. These novel contact lenses allow users to focus simultaneously on objects that are close up and far away. This could improve ability to use tiny portable displays while sill interacting with the surrounding environment.

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Scooped by Dr. Stefan Gruenwald
February 2, 2012 11:46 AM
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Computational method predicts new uses for existing medicines

Computational method predicts new uses for existing medicines | Amazing Science | Scoop.it

For the first time ever, scientists are using computers and genomic information to predict new uses for existing medicines. “Bringing a new drug to market typically takes about $1 billion, and many years of research and development,” said Rochelle M. Long, Ph.D., who directs the NIH Pharmacogenomics Research Network. “If we can find ways to repurpose drugs that are already approved, we could improve treatments and save both time and money.”

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 7:13 PM
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How did AIDS/HIV begin? From chimps to man - a history lesson

How did AIDS/HIV begin? From chimps to man - a history lesson | Amazing Science | Scoop.it

The story begins sometime close to 1921, somewhere between the Sanaga River in Cameroon and the Congo River in the former Belgian Congo. It involves chimps and monkeys, hunters and butchers, “free women” and prostitutes, syringes and plasma-sellers, evil colonial lawmakers and decent colonial doctors with the best of intentions. And a virus that, against all odds, appears to have made it from one ape in the central African jungle to one Haitian bureaucrat leaving Zaire for home and then to a few dozen men in California gay bars before it was even noticed — about 60 years after its journey began.

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 5:55 PM
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Neurolearning: Mathematical Minds

Neurolearning: Mathematical Minds | Amazing Science | Scoop.it

"Most mathematicians did not just take up math as a "job"...(most) get more pleasure out of mathematics than almost any other activity. And they often discovered this pleasure when they were young". While most people would agree that "math people" are not like "non-math people", it's not always easy for non-mathematical minds to recognize (and appropriately nurture) mathematical ones.

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 3:18 PM
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River Monsters: Fish Swims Up Urine Stream

Candiru (English and Portuguese) or cañero (Spanish), also known as toothpick or vampire fish, are a number of genera of parasitic freshwater catfish in the Trichomycteridae family. All are native to the Amazon River. Although some candiru species have been known to grow to a size of 40 centimetres (16 inches) in length, others are considerably smaller. These smaller species are known for an alleged tendency to invade and parasitize the human urethra by swimming up the urine stream. However, despite ethnological reports dating back to the late 19th century, the first documented case of the removal of a candiru from a human urethra did not occur until 1997.

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 2:19 PM
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Interactive Smart Phone and Tablet Medical Textbooks Gain Traction

Interactive Smart Phone and Tablet Medical Textbooks Gain Traction | Amazing Science | Scoop.it

Medical textbooks are brought to life in 2012 by interactive graphs and figures, customized quizzes, beautiful multimedia, social media integration, and an innovative user interface.

 

http://tinyurl.com/8a3wqsv

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 1:52 PM
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GWAS study shows that human intelligence is highly heritable and polygenic

GWAS study shows that human intelligence is highly heritable and polygenic | Amazing Science | Scoop.it

Individual differences in intelligence are strongly associated with many important life outcomes, including educational and occupational attainments, income, health and lifespan. Data from twin and family studies are consistent with a high heritability of intelligence, but this inference has been controversial. We conducted a genome-wide analysis of 3511 unrelated adults with data on 549 692 single nucleotide polymorphisms (SNPs) and detailed phenotypes on cognitive traits.

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 1:44 AM
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The origin of malaria

The origin of malaria | Amazing Science | Scoop.it

Several million years ago, Plasmodium falciparum – the parasite that causes most cases of human malaria – jumped into humans from other apes. We’ve known as much for decades but for all this time, we’ve pinned the blame on the wrong species. A new study reveals that malaria is not, as previously thought, a disease that came from chimpanzees; instead it’s an unwanted gift from gorillas.

 

Until now, the idea of chimps as the source of human malaria seemed like a done deal. Just last year, I covered a study which said that a related chimp parasite called Plasmodium reichenowi is the ancestor of P.falciparum.According to Stephen Rich from the University of Massachussetts,P.reichenowi crossed the species barrier from chimps to humans just once in history – a defining moment that gave rise to P.falciparum.

 

But to Weimin Liu from the University of Alabama, something wasn’t quite right. People seemed to have settled on a chimpanzee conclusion without thoroughly testing for Plasmodium in other apes. Fortunately, Liu’s team was well placed to fill in those blanks. For their research, they had already amassed a massive collection of ape faeces: an unenviable collection of 1,827 samples from chimps, 805 from gorillas and 107 from bonobos. Virtually all of these samples came from wild apes with little human contact; only 28 came from a habituated group of gorillas.

 

Liu scoured all of these samples for Plasmodium DNA, sequenced what he could find, and built a family tree that charted the evolutionary relationships between them. His results were very clear. For a start, Plasmodium parasites don’t infect either eastern gorillas or bonobos, but they do infect chimpanzees and western gorillas. That narrows down the source of human malaria to these two apes.

 

Liu also found that all of the samples of P. falciparum taken from humans were most closely related to a single lineage of gorilla parasites. P.reichenowiis an exclusively chimp parasite, belonging to a different branch of thePlasmodium family tree. The answer was clear: P.falciparum did not evolve from P.reichenowi and it didn’t come from chimpanzees. Instead, it jumped into humans from western gorillas.

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Scooped by Dr. Stefan Gruenwald
February 1, 2012 12:41 AM
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Prof. Stephen Hawking turns 70 and defies the odds of medicine

Prof. Stephen Hawking turns 70 and defies the odds of medicine | Amazing Science | Scoop.it

The former Lucasian professor of mathematics and theoretical physics at the University of Cambridge is widely regarded as one of the most brilliant theoretical physicists since Einstein. He has 12 honorary degrees, a CBE and in 2009 he was awarded the Presidential Medal of Freedom, the highest civilian award in the US. Now aged 70, he has long defied and baffled medical experts who predicted he had just months to live in 1963 when he was diagnosed with Motor Neurone Disease (MND).

 

Key points of Dr. Hawking's life:

 

  • Born in Oxford on 8 Jan 1942, brought up in St Albans. Father a research biologist, mother a radical free-thinker
  • Labelled a swot at public school, he liked horse riding, rowing, classical music and debating
  • A Brief History of Time - the 1988 layman's guide to cosmology - has sold 10 million copies worldwide
  • Discovered "Hawking radiation", where black holes leak energy and fade to nothing, and "theory of everything" suggesting universe evolves according to well-defined laws
  • Popular ambassador for science, he lent his synthesized voice to various recordings and appeared in BBC comedy Red Dwarf, The Simpsons and Star Trek
  • In 2001, he claimed mankind could be wiped out by a genetically engineered "doomsday" virus
  • In an interview with the New Scientist ahead of his 70th birthday, he said he spent most of the day thinking about women, who he says are "a complete mystery"
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