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Allergy Immunology | Young adults with IgE-mediated cow’s milk allergy had significantly reduced bone mineral density and a significant risk for early osteoporosis that appeared to be reversible with milk desensitization, according to recent study... 
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Allergy Immunology | Swedish schoolchildren showed a high incidence of perceived food hypersensitivity, particularly to cow’s milk, according to recent study results.
Gilbert C FAURE's insight:
Researchers studied a population-based cohort of 2,585 children (aged 7 to 8 years) from three Swedish towns who participated in a parental questionnaire in 2006. Ninety percent of children from two of the towns (n=1,700) also participated in skin prick testing (SPT) with airborne allergens. In 2010, when the children were aged 11 to 12 years, the same methods were used, with 89% participation. At follow-up, 652 children in the SPT cohort provided a blood sample for analysis of IgE-antibodies. There was an increase in perceived food hypersensitivity (FHS) from 21.4% (aged 8 years) to 25.9% (aged 12 years; P<.001), with cumulative incidence of food hypersensitivity of 14.7% and remission at 32.7% during that period. “This pattern was particularly evident for hypersensitivity to cow’s milk [9% to 13%; P<.001], while the incidence of hypersensitivity to other foods was lower,” the researchers wrote. Incidence of FHS was associated with female sex (OR=1.8; 95% CI, 1.3-2.5), allergic heredity (OR=1.6; 95% CI, 1.2-2.1), current rhinitis (OR=3.4; 95% CI, 1.9-5.9) and allergic sensitization (OR=1.6; 95% CI, 1.1-2.3). There was a negative association between allergic sensitization and remission. Hypersensitivity to milk had different risk-factor patterns for incidence and remission compared with other foods. “Generally, the agreement between reported [FHS] and IgE-sensitization to the implicated food was poor,” the researchers wrote. “There was a high prevalence, a high cumulative incidence and a high remission of perceived FHS,” the researchers concluded. “Further studies including diagnostic methods are needed to evaluate the association between reported symptoms to food and true FHS. This is particularly important for the large number of children reporting FHS to essential foods like cow’s milk.”
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RT @Aller_MD: High incidence and remission of reported food hypersensitivity in Swedish children followed from 8... http://t.co/U5hPMr8DRU
Gilbert C FAURE's insight:
In this longitudinal, population-based cohort-study perceived food hypersensitivity was common among children between ages 8 and 12, often transient and not well correlated with food-specific IgE. While these findings suggest an overestimated prevalence of food hypersensitivity, the public-health-significance remains high as they reflect the perceived reality to which the children adapt their life and food intakes.
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by Asma Kassas, Ivan C. Moura, Yumi Yamashita, Jorg Scheffel, Claudine Guérin-Marchand, Ulrich Blank, Peter J. Sims, Therese Wiedmer, Renato C.
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Allergy Immunology | Eosinophilic esophagitis occurred in nearly 3% of patients with immunoglobulin E-mediated food allergy who had undergone oral immunotherapy in a recent study.
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Activation of the P2X7 receptor induces the rapid shedding of CD23 from human ...
Gilbert C FAURE's insight:
Activation of the P2X7 receptor by the extracellular damage-associated molecular pattern, adenosine 5′-triphosphate (ATP), induces the shedding of cell surface molecules including the low-affinity IgE receptor, CD23, from human leukocytes. A disintegrin and metalloprotease (ADAM) 10 mediates P2X7-induced shedding of CD23 from multiple myeloma RPMI 8226 B cells; however, whether this process occurs in primary B cells is unknown.
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Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test (New article: Severe hypersensitivity reactions to cetuximab #LibertasAcademica #anaphylaxis
Gilbert C FAURE's curator insight,
July 25, 2014 4:49 AM
pour plus d'informations récentes sur le cituximab dans ce sujet http://www.scoop.it/t/immunology-and-biotherapies?q=cetuximab
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New treatment option in development for individuals with food allergy EurekAlert (press release) Ongoing trials are exploring options for oral immunotherapy (OIT) for desensitization in the treatment of Immunoglobulin E (IgE)-mediated food allergy,...
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dog non-seasonal pruritic dermatitis #food_allergies: allergen-specific lymphocyte proliferation & IgE useful http://t.co/Z0enUJzqsj
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Treating severe allergic asthma with anti-IgE monoclonal antibody (omalizumab): a review - up-to-the-minute news and headlines. 7thSpace is a online portal covering topics such as Family, Business, Entertainment, Headlines, Recipes and more.
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Allergen-specific immunotherapy (SIT) offers a disease specific causative treatment by inducing tolerance to the allergen and preventing progression of allergic diseases. It may be considered in patients allergic to furry animals. Current mammalian allergy vaccines are still prepared from relatively poorly defined allergen extracts and may induce immediate and late phase side effects. Although the mechanisms of SIT are still not fully understood, the more recent approaches report different strategies to reduce both allergen-specific IgE as well as T cell reactivity. The availability of recombinant allergens and synthetic peptides from mammalian species has contributed to formulating new allergy vaccines to improve SIT for furry animal allergy. The majority of studies have focused on the major cat allergen Fel d 1 due to it’s extensively characterization in terms of IgE and T-cell epitopes and to its dominant role in cat allergy. Here we review the most recent approaches, e.g. synthetic peptides, recombinant allergen derivatives, different hypoallergenic molecules, recombinant allergens coupled to virus-like particles or immunomodulatory substances as well as strategies targeting the allergen to Fc receptors and the MHC class II pathway using a new route for administration. Many of the new vaccines hold promise but only a few of them have been investigated in clinical trials which will be the gold standard for evaluation of safety and efficacy in allergic patients.
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Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that regulates immune and inflammatory responses through interactions with a variety of signaling and transcriptional molecules.
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Allergy Immunology | Serological cross-reactivity between species was frequent in fish allergic patients but had limited clinical relevance, according to recent data.
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Immunology: IgE, IgG4 and IgA specific for Bet v 1‐related food allergens do not predict oral allergy syndrome http://t.co/RlHje2s3L8
Gilbert C FAURE's insight:
Conclusion
Measurements of allergen-specific immunoglobulins are not suitable for diagnosing Bet v 1-mediated plant food allergy to hazelnut and Rosaceae fruits. In contrast, IgE and IgA to the distantly related allergen Api g 1 correlate with allergy to celeriac.
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HCPLive Understanding and Applying the Newest Guidelines for Food Allergy HCPLive Evaluation of sudden IgE allergy requires a careful history, physical examination, tests and background knowledge of common triggers such as peanut, tree nut, milk,...
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Omalizumab is a monoclonal antibody to IgE approved for mod-severe asthma and chronic idiopathic hives. #tallergy http://t.co/QWAMPxqTw8
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Do not get #foodallergy testing unless the history suggests IgE reactions! Choosing Wisely @AAAAI_org http://t.co/f3E0zq7dJK
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Anaphylactic reaction linked to fruit antibiotic
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Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 ...
Gilbert C FAURE's insight:
Treg and Breg cells together have a role in suppression of IgE and induction of IgG4 isotype allergen-specific antibodies particularly mediated by IL-10. Other cell types such as subsets of dendritic cells, NK-T cells and natural killer cells producing high levels of IL-10 may also contribute to the generation of healthy immune responses to allergens.
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A highly-sensitive method has been developed that can quickly and accurately identify proteins that cause allergic reactions even at very low concentrations. Via JIB Biology
Gilbert C FAURE's insight:
specific IgE only
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Modified food challenge for peanut allergy could determine thresholds Healio Peanut- and Ara h 2-specific IgE levels, skin prick test responses, basophil activation, and TH2 cytokine production by peripheral blood mononuclear cells were...
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Immunology: IgE antibodies to alpha‐gal in the general adult population. Relationship with tick bites, atopy, ... http://t.co/O6tW7a1LF7
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by Jyoti Balhara, Naresh Singh Redhu, Lianyu Shan, Abdelilah S.
Gilbert C FAURE's insight:
for asthma
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Hypersensitivity and desensitization, Allergy/Clinical Immunology, journals , abstracts, epgonline (Background: Desensitization to antineoplastic agents is becoming a standard of care. Efforts to establish and...
Gilbert C FAURE's insight:
Background: Desensitization to antineoplastic agents is becoming a standard of care. Efforts to establish and improve these techniques are being made at many institutions. Our aims are to evaluate a new rapid desensitization protocol designed to be shorter (approximately 4 h) and safer (reducing hazardous drugs exposure risks) and to assess the oxaliplatin-specific immunoglobulin E (IgE) as a novel diagnostic tool. Methods: Prospective, observational, longitudinal study with patients who, for a 1-year period, suffered reactions to antineoplastic agents and were referred to the Desensitization Program at Ramon y Cajal University Hospital (RCUH). Patients were included or excluded as desensitization candidates after anamnesis, skin testing, risk assessment, and graded challenge. Specific IgE was determined in oxaliplatin-reactive patients. Candidate patients were desensitized using the new RCUH rapid desensitization protocol. Results: Of 189 intravenous rapid desensitizations, 188 were successfully accomplished in the 23 patients who met inclusion criteria for desensitization (of 58 referred patients). No breakthrough reactions occurred in 94% of desensitizations, and most breakthrough reactions were mild. In 10 oxaliplatin-reactive patients, 38 desensitizations were successfully accomplished. Sensitivity for oxaliplatin-specific IgE was 38% (0.35UI/l cutoff point) and 54% (0.10UI/l cutoff point); specificity was 100% for both cutoff points. Conclusions: In the hands of a Desensitization Program, managed by drug desensitization experts, this new protocol has proven an effective therapeutic tool for hypersensitivity to several antineoplastic agents (oxaliplatin, carboplatin, paclitaxel, docetaxel, cyclophosphamide, and rituximab); moreover, it improves safety handling of hazardous drugs. We report the first large series of oxaliplatin desensitizations. Oxaliplatin-specific IgE determination could be helpful. - See more at: http://www.epgonline.org/journals/hypersensitivity-and-desensitization-to-antineoplastic.cfm#sthash.OIR2ZZy6.4MvQlov0.dpuf
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