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Scientists from the CNRS, INSERM and Université de Limoges have demonstrated that the production of type E immunoglobulins (IgE)2 by B lymphocytes induces a loss in their mobility and the initiatio... 
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Production of the powerful IgE antibody results in the destruction of its own factory B cell, a new study reveals.
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The IgE response has been associated with both allergic reactions and immunity to metazoan parasites.
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Oral immunotherapy induces IgG antibodies that act via FcγRIIb to suppress IgE-mediated hypersensitivity, http://t.co/wnWK8DrgSx
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Allergen-specific IgE is linked to asthma pathogenesis, but the underlying mechanisms of IgE production in response to allergen exposure are poorly understood.
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Food allergy: A practice parameter update—2014 - Journal of Allergy and Clinical Immunology http://t.co/uv1BEgHByb
Gilbert C FAURE's insight:
Table of contentsI.
Classification of major food allergens, cross-reactivities, genetically modified foods, and clinical implications A.Classification B.Cross-reactivity C.Genetically modified organisms in foods and the potential for allergenicity II.Mucosal immune responses induced by foods III.The clinical spectrum of food allergy A.Categories of adverse food reactions B.Definitions of specific food-induced allergic conditions IV.Prevalence, natural history, and prevention A.Natural history B.Prevention of food allergy V.Adverse reactions to food additives VI.Diagnosis of food allergy, differential diagnosis, and diagnostic algorithm A.Diagnosis of IgE-mediated food allergy B.Non-IgE mediated: FPIES, allergic proctocolitis, and enteropathy C.Eosinophilic esophagitis D.Eosinophilic gastroenteritis VII.Management of food allergy and food-dependent, exercise-induced anaphylaxis VIII.Emerging therapies for food allergy IX.Management in special settings
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Allergy Immunology | Serological cross-reactivity between species was frequent in fish allergic patients but had limited clinical relevance, according to recent data.
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Immunology: IgE, IgG4 and IgA specific for Bet v 1‐related food allergens do not predict oral allergy syndrome http://t.co/RlHje2s3L8
Gilbert C FAURE's insight:
Conclusion
Measurements of allergen-specific immunoglobulins are not suitable for diagnosing Bet v 1-mediated plant food allergy to hazelnut and Rosaceae fruits. In contrast, IgE and IgA to the distantly related allergen Api g 1 correlate with allergy to celeriac.
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HCPLive Understanding and Applying the Newest Guidelines for Food Allergy HCPLive Evaluation of sudden IgE allergy requires a careful history, physical examination, tests and background knowledge of common triggers such as peanut, tree nut, milk,...
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Omalizumab is a monoclonal antibody to IgE approved for mod-severe asthma and chronic idiopathic hives. #tallergy http://t.co/QWAMPxqTw8
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Do not get #foodallergy testing unless the history suggests IgE reactions! Choosing Wisely @AAAAI_org http://t.co/f3E0zq7dJK
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Anaphylactic reaction linked to fruit antibiotic
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Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 ...
Gilbert C FAURE's insight:
Treg and Breg cells together have a role in suppression of IgE and induction of IgG4 isotype allergen-specific antibodies particularly mediated by IL-10. Other cell types such as subsets of dendritic cells, NK-T cells and natural killer cells producing high levels of IL-10 may also contribute to the generation of healthy immune responses to allergens.
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Scientists from the CNRS, INSERM and Université de Limoges, working in the Laboratoire Contrôle de la Réponse Immune B et Lymphoproliférations (CNRS/Université de Limoges) have demonstrated that the production of type E immunoglobulins (IgE) by B...
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Immunology. 2015 Jan;144(1):107-15. doi: 10.1111/imm.12355. Research Support, Non-U.S. Gov't
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Progression from non-IgE mediated milk allergy to immediate hypersensitivity: http://t.co/vqOokrBXzD #BSPGHAN #milkallergy
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Immunological cross-reactivity between environmental allergens and helminth proteins has been demonstrated, although the clinically related implications of this cross-reactivity have not been addressed.
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The physiologic function of the "odd" Ab IgG4 remains enigmatic.
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Allergy Immunology | Young adults with IgE-mediated cow’s milk allergy had significantly reduced bone mineral density and a significant risk for early osteoporosis that appeared to be reversible with milk desensitization, according to recent study...
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Allergy Immunology | Swedish schoolchildren showed a high incidence of perceived food hypersensitivity, particularly to cow’s milk, according to recent study results.
Gilbert C FAURE's insight:
Researchers studied a population-based cohort of 2,585 children (aged 7 to 8 years) from three Swedish towns who participated in a parental questionnaire in 2006. Ninety percent of children from two of the towns (n=1,700) also participated in skin prick testing (SPT) with airborne allergens. In 2010, when the children were aged 11 to 12 years, the same methods were used, with 89% participation. At follow-up, 652 children in the SPT cohort provided a blood sample for analysis of IgE-antibodies. There was an increase in perceived food hypersensitivity (FHS) from 21.4% (aged 8 years) to 25.9% (aged 12 years; P<.001), with cumulative incidence of food hypersensitivity of 14.7% and remission at 32.7% during that period. “This pattern was particularly evident for hypersensitivity to cow’s milk [9% to 13%; P<.001], while the incidence of hypersensitivity to other foods was lower,” the researchers wrote. Incidence of FHS was associated with female sex (OR=1.8; 95% CI, 1.3-2.5), allergic heredity (OR=1.6; 95% CI, 1.2-2.1), current rhinitis (OR=3.4; 95% CI, 1.9-5.9) and allergic sensitization (OR=1.6; 95% CI, 1.1-2.3). There was a negative association between allergic sensitization and remission. Hypersensitivity to milk had different risk-factor patterns for incidence and remission compared with other foods. “Generally, the agreement between reported [FHS] and IgE-sensitization to the implicated food was poor,” the researchers wrote. “There was a high prevalence, a high cumulative incidence and a high remission of perceived FHS,” the researchers concluded. “Further studies including diagnostic methods are needed to evaluate the association between reported symptoms to food and true FHS. This is particularly important for the large number of children reporting FHS to essential foods like cow’s milk.”
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RT @Aller_MD: High incidence and remission of reported food hypersensitivity in Swedish children followed from 8... http://t.co/U5hPMr8DRU
Gilbert C FAURE's insight:
In this longitudinal, population-based cohort-study perceived food hypersensitivity was common among children between ages 8 and 12, often transient and not well correlated with food-specific IgE. While these findings suggest an overestimated prevalence of food hypersensitivity, the public-health-significance remains high as they reflect the perceived reality to which the children adapt their life and food intakes.
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by Asma Kassas, Ivan C. Moura, Yumi Yamashita, Jorg Scheffel, Claudine Guérin-Marchand, Ulrich Blank, Peter J. Sims, Therese Wiedmer, Renato C.
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Allergy Immunology | Eosinophilic esophagitis occurred in nearly 3% of patients with immunoglobulin E-mediated food allergy who had undergone oral immunotherapy in a recent study.
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Activation of the P2X7 receptor induces the rapid shedding of CD23 from human ...
Gilbert C FAURE's insight:
Activation of the P2X7 receptor by the extracellular damage-associated molecular pattern, adenosine 5′-triphosphate (ATP), induces the shedding of cell surface molecules including the low-affinity IgE receptor, CD23, from human leukocytes. A disintegrin and metalloprotease (ADAM) 10 mediates P2X7-induced shedding of CD23 from multiple myeloma RPMI 8226 B cells; however, whether this process occurs in primary B cells is unknown.
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