Set in Pasadena, California, the show is centered around five characters: two roommate Caltech geniuses, experimental physicist Leonard Hofstadter and theoretical physicist Sheldon Cooper; their neighbor across the hall Penny, an attractive blonde waitress and aspiring actress; and Leonard's and Sheldon's equally geeky and socially awkward co-workers and friends Howard Wolowitz, an Aerospace engineer and a non-PhD from JPL, and Rajesh Koothrappali, a particle astrophysicist postdoc also working at Caltech. The geekiness and intellect of the four guys are contrasted for comic effect with Penny's social skills and common sense.
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