Thanks to shRNA lentiviral vectors which target promyelocytic leukemia (PML), the authors show PML depletion induces telomere damage, nuclear and chromosomal abnormalities, and senescence. This work provides a novel view of the physiologic function of PML, which participates in telomeres surveillance in normal cells.
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Thanks to shRNA lentiviral vectors which target promyelocytic leukemia (PML), the authors show PML depletion induces telomere damage, nuclear and chromosomal abnormalities, and senescence. This work provides a novel view of the physiologic function of PML, which participates in telomeres surveillance in normal cells.
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