Vectorology - GEG Tech top picks

In this work, the scientists have demonstrated that lentiviral vectors can package and deliver inserts of a similar size to dystrophin. They report a novel approach for delivering large transgenes in lentiviruses, in which they demonstrate proof-of-concept for a 'template-switching' lentiviral vector that harnesses recombination events during reverse-transcription. Their results shown gene therapy with this vector by restoring dystrophin expression in DMD myoblasts, where dystrophin was expressed at the sarcolemma of myotubes after myogenic differentiation.