Animal Models - GEG Tech top picks

This present study was performed to evaluate the beneficial effects of lentiviral vector-mediated overexpression of a combination of three transcription regulators, ABN (Ascl1, Brn2 and Ngn2), on learning and memory loss in a mouse model of Alzheimer's disease (AD). The AD model was established by injecting Aβ1–42 bilaterally into the mouse hippocampus. Animals injected with LV-ABN showed significantly improved spatial learning and memory in the water maze test. Additionally, antibody array analysis indicated that intrahippocampal LV-ABN delivery significantly altered the expression levels of some proteins that were identified as inflammatory factors or neuroprotective and growth factors. These findings indicate that lentiviral ABN gene delivery has potential therapeutic applications for AD.