Science Index's Rheumatology category covers diagnosis and therapy of rheumatic diseases including problems involving joints, soft tissues and connective tissues. It currently contains 5,383 articles partly derived from 28 ...
An updated economic evaluation was conducted to compare the cost-effectiveness of the four tumour necrosis factor (TNF)-α inhibitors adalimumab, etanercept, golimumab and infliximab in active, progressive psoriatic arthritis (PsA) where response to standard treatment has been inadequate.
Gilbert C FAURE's insight:
medico economic informations are mandatory in this disorder, according to the new therapies available..
... to suppress pathological immune responses in several settings. The aim of this study was to evaluate the therapeutic potential of collagen type II-specific Tr1 (Col-Treg) cells in two models of rheumatoid arthritis (RA) in mice.
To develop personalized medicine strategies for improvement of patient management in rheumatoid arthritis, the clinical and molecular properties of the individual patients need to be well characterized. A crucial step in this approach is to discover subgroups of patients that are characterized by a good or poor treatment outcome. Dennis and colleagues have identified distinct pretreatment gene expression profiles in affected synovial tissue specimens and a tissue type-related systemic protein pattern which are associated with a positive or negative clinical outcome to monotherapy with adalumimab (anti-TNFα) and tocilizumab (anti-IL-6 receptor). These observations assign biological pathways associated with response outcome and provide evidence for the existence of systemic, easy-to-measure predictive biomarkers for clinical benefit of these biologics.
Our objective was to determine the signaling pathway of interleukin-10 (IL-10) for modulating interleukin-17 (IL-17) expression in macrophages and the importance of this mediation in collagen-induced arthritis (CIA).
Purpose of reviewTo review novel therapeutic targets that are currently under investigation to develop safer, targeted therapies for antiphsopholipid antibody (aPL)-mediated clinical manifestations. Recent findingsNovel therapeutic options potentially available include anti-CD20 monoclonal antib...
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:
This is the first of three reviews focusing on OA therapeutics. This paper provides an overview of current research into potential structure-modifying drugs and more appropriately targeted pharmacological therapy. The challenges and opportunities in this area of research and development are reviewed, covering the most up-to-date initiatives, trends, and topics.
We aimed to elucidate the role of four polymorphisms identified in a genome-wide association study (GWAS) analyzing the response of patients with rheumatoid arthritis (RA) to treatment with tumor necrosis factor inhibitors ...
Gilbert C FAURE's insight:
Our data suggest that the rs12081765, rs1532269, rs17301249 and rs7305646 genetic variants do not have a role as genetic predictors of the TNFi treatment outcome.
Yuelong Cao, Graeme Jones, Weiyu Han, Benny Antony, Xia Wang, Flavia Cicuttini and Changhai Ding. Author Affiliations. For all author emails, please log on. Arthritis Research & Therapy 2014, 16:R59 doi:10.1186/ar4496.
Gilbert C FAURE's insight:
Popliteal cysts and subgastrocnemius bursitis are associated with increased symptoms as well as radiographic and MRI-detected joint structural abnormalities. Longitudinal data will help resolve if they are a consequence or a cause of knee joint abnormalities.
Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes a considerable burden for the patient and society. It is not clear yet whether aiming for remission (REM) is worthwhile, especially when compared to low ...
Antibodies against citrullinated peptides (anti-CCP) and increased levels of cytokines precede the development of rheumatoid arthritis (RA) by several years. Recently, the proteins survivin and Fms-like tyrosine kinase 3 ...
J. M. van Laar, Editor in Chief of Rheumatology Journal, speaks with Dr. Joachim Listing, of the German Rheumatism Research Centre, about the impact of biolo...
Rheumatoid arthritis (RA) is a complex and clinically heterogeneous autoimmune disease. Currently, the relationship between pathogenic molecular drivers of disease in RA and therapeutic response is poorly understood.
Shock therapy improves pain and function in patients with chronic calcific shoulder tendinitis, according to an article published in Annals of Internal Medicine.
The aims of this study were to assess agreement between the currently used 2002 American-European Consensus Group (AECG) classification criteria and the new 2012 American College of Rheumatology (ACR) criteria for ...
Gilbert C FAURE's insight:
.... classification criteria for Sjogren's syndrome and reasons for discrepancies
Conclusions
Agreement was only moderate between ACR and AECG criteria, suggesting these two sets would not select comparable patient populations. An international consensus about which classification criteria should be used in clinical studies is needed.
Development of anti-citrullinated protein antibody and rheumatoid factor isotypes prior to the onset of rheumatoid arthritis. Wouter H Bos, Lotte A van de Stadt, Azita Sohrabian, Johan Rönnelid and Dirkjan van Schaardenburg ...
Gilbert C FAURE's insight:
In the preclinical phase of RA, IgG ACPA comes first, followed by IgA, and then by IgM. For RF, the IgG subtype seems to appear after IgA and IgM. As postulated previously [3], the IgG-dominated anti-CCP pattern might reflect a mature T cell-dependent immune reaction, whereas the IgM-dominated RF response might represent a non-isotype switched T cell-independent immune response. All investigated autoantibodies rise over time before RA diagnosis. Finally, smoking seems to influence both IgA APCA and IgA RF levels and this is in line with the hypothesis that smoking induces or augments a mucosa-related immune response in lungs.
Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for de novo vessel formation and ...
Gilbert C FAURE's insight:
We conclude that Id1 correlates highly with CXCL16 expression, EPC recruitment, and blood vessel formation in the RA joint, and that Id1 is potently angiogenic and can be upregulated in EPCs by CXCL16.
Decline in Rates of Joint Surgery Seen Reflecting Better Disease Control Anesthesiology News San Diego—Rates of orthopedic surgery are declining among patients with rheumatoid arthritis (RA), at the same time that aggressive therapy with biologics...
Patients with rheumatoid arthritis who don't do well with first-line biologic therapy may soon have another therapeutic option: monoclonal antibodies that target granulocyte-macrophage colony-stimulat (RT @MedicalNews: Rheuminations: New RA...
Rheumatology | Patients with axial spondylarthritis treated with tumor necrosis factor inhibitors showed a better correlation with improvement in inflammation in the first 4 years of disease compared with longer disease duration, according to...
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from 2012?