Rheumatology-Rhumatologie
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Scooped by Gilbert C FAURE
December 4, 2015 9:52 AM
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Targeting of proangiogenic signalling pathways in chronic inflammation

Sander W. Tas,Chrissta X. Maracle,Emese Balogh& Zoltán SzekaneczAffiliationsContributionsCorresponding authorNature Reviews Rheumatology (2015) doi:10.1038/nrrheum.2015.164Published online 03 December 2015
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Angiogenesis is de novo capillary outgrowth from pre-existing blood vessels. This process not only is crucial for normal development, but also has an important role in supplying oxygen and nutrients to inflamed tissues, as well as in facilitating the migration of inflammatory cells to the synovium in rheumatoid arthritis, spondyloarthritis and other systemic autoimmune diseases. Neovascularization is dependent on the balance of proangiogenic and antiangiogenic mediators, including growth factors, cytokines, chemokines, cell adhesion molecules and matrix metalloproteinases. This Review describes the various intracellular signalling pathways that govern these angiogenic processes and discusses potential approaches to interfere with pathological angiogenesis, and thereby ameliorate inflammatory disease, by targeting these pathways.

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Scooped by Gilbert C FAURE
September 28, 2015 10:00 AM
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American College of Rheumatology Releases New Ankylosing Spondylitis & Non ... - Newswise (press release)

The American College of Rheumatology (ACR) has released new recommendations for the treatment of ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (SpA).
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Scooped by Gilbert C FAURE
February 15, 2015 2:23 PM
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Impaired response to treatment with tumour necrosis factor α inhibitors in smokers with axial spondyloarthritis -- Ciurea et al. -- Annals of the Rheumatic Diseases

RT @bmj_company: Smoking impairs treatment response in inflammatory back #arthritis, shows research in @ARD_BMJ http://t.co/s7wosYFY71 http…
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Scooped by Gilbert C FAURE
October 29, 2014 9:34 AM
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Vitamin D and spondyloarthritis, Expert Review of Clinical Immunology, Informa Healthcare

Vitamin D and spondyloarthritis, Expert Review of Clinical Immunology, Informa Healthcare | Rheumatology-Rhumatologie | Scoop.it
Vitamin D and spondyloarthritis: Expert Review of Clinical Immunology, Ahead of Print.
http://t.co/kwU40DscOQ
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Scooped by Gilbert C FAURE
June 20, 2014 1:52 AM
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EULAR releases first SpA imaging guidelines - Rheumatology Update

EULAR releases first SpA imaging guidelines - Rheumatology Update | Rheumatology-Rhumatologie | Scoop.it
EULAR releases first SpA imaging guidelines
Rheumatology Update
The first guidelines for imaging in axial and peripheral spondyloarthritis have been presented to the conference this afternoon.
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Scooped by Gilbert C FAURE
August 29, 2013 3:27 PM
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Report from the Latin American Spondyloarthritis Society for education and research in immunology and medicine organization 2012 workshop

Report from the Latin American Spondyloarthritis Society for education and research in immunology and medicine organization 2012 workshop | Rheumatology-Rhumatologie | Scoop.it
Rheumatology Medical Article: Report from the Latin American Spondyloarthritis Society for education and research in immunology and medicine organization 2012 workshop (Report from the Latin American Spondyloarthritis Society for education and...
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Scooped by Gilbert C FAURE
November 16, 2015 5:40 AM
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The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma

IntroductionAn increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA).
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August 28, 2015 5:57 AM
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Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort

Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort | Rheumatology-Rhumatologie | Scoop.it
by Gaetane Nocturne, Stephan Pavy, Saida Boudaoud, Raphaèle Seror, Philippe Goupille, Philippe Chanson, Désirée van der Heijde, Floris van Gaalen, Francis Berenbaum, Xavier Mariette, Karine Briot, Antoine Feydy, Pascal Claudepierre, Philippe...
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January 8, 2015 2:25 PM
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Pfizer granted European approval for Enbrel in early-stage ...

Pfizer granted European approval for Enbrel in early-stage ... | Rheumatology-Rhumatologie | Scoop.it
This affects the spine and sacroiliac joints, and 'non-radiographic' refers to patients whose disease is not sufficiently advanced as to be detectable by x-ray. As many as 12% of non-radiographic axial spondyloarthritis progress ...
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Scooped by Gilbert C FAURE
September 1, 2014 2:21 PM
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Calprotectin (S100A8/9) as serum biomarker for clinical response in proof-of-concept trials in axial and peripheral spondyloarthritis

IntroductionBiomarkers complementing clinical evaluations may help to reduce the length and size of proof-of-concept (PoC) trials aimed to obtain quick ?go/no go? decisions in the clinical development of new treatments.
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Scooped by Gilbert C FAURE
May 23, 2014 2:30 PM
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Tumor necrosis factor inhibitor therapy but not standard therapy is associated with resolution of erosion in the sacroiliac joints of patients with axial spondyloarthritis

IntroductionRadiography is an unreliable and insensitive tool for the assessment of structural lesions in the sacroiliac joints (SIJ).
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Scooped by Gilbert C FAURE
August 25, 2013 2:16 PM
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Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells

Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells | Rheumatology-Rhumatologie | Scoop.it
Rheumatology Medical Article: Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells (Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by...
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