Base Excision Repair Variants and Pesticide Exposure Increase Parkinson’s Disease Risk | Toxicological Sciences – Oxford Academic | Prévention du risque chimique | Scoop.it
From academic.oup.com - July 31, 2017 4:13 AM

Exposure to certain pesticides induces oxidative stress and increases Parkinson’s disease (PD) risk. Mitochondrial DNA (mtDNA) damage is found in dopaminergic neurons in idiopathic PD and following pesticide exposure in experimental models thereof.


Base excision repair (BER) is the major pathway responsible for repairing oxidative DNA damage in cells. Whether single nucleotide polymorphisms (SNPs) in BER genes alone or in combination with pesticide exposure influence PD risk is unknown.