All general explanations (and more) about Adhesion Molecules in the Course of Advanced Molecular Genetics-Biology 566, Western Kentucky University
Author: claire.rinehart@wku.edu
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Immunology for University Students
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Resources and Material for Lecturers and Students - Immunology (University level)
Curated by
Alfredo Corell
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Por Armando Hasudungan http://www.youtube.com/user/armandohasudungan
Describes how genes that make light and heavy chains can be randomly assorted to produce a unique type of antibody and so wil bind to a specific antigen~ Fac... 
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Your Amazing Immune system interactive book features an immune system game and a free immune system pdf, for everyone to learn and discover more about the way your body protects itself.
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You can also complete state mandated continuing education here. We offer courses mandated by some states for nurses and other healthcare professionals. Access them from the "State Mandated Courses" listed above.
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Nature Immunology13,1072–1082(2012)doi:10.1038/ni.2408
Hematopoietic stem and progenitor cells (HSPCs) are regulated by various bone marrow stromal cell types. Here we identified rare activated bone marrow monocytes and macrophages with high expression of α-smooth muscle actin (α-SMA) and the cyclooxygenase COX-2 that were adjacent to primitive HSPCs. These myeloid cells resisted radiation-induced cell death and further upregulated COX-2 expression under stress conditions. COX-2-derived prostaglandin E2 (PGE2) prevented HSPC exhaustion by limiting the production of reactive oxygen species (ROS) via inhibition of the kinase Akt and higher stromal-cell expression of the chemokine CXCL12, which is essential for stem-cell quiescence. Our study identifies a previously unknown subset of α-SMA+ activated monocytes and macrophages that maintain HSPCs and protect them from exhaustion during alarm situations.
Original article in Nature Immunology: http://www.nature.com/ni/journal/v13/n11/full/ni.2408.html
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All about Innate Immunology (text, animations, figures) at Dr. Kaiser BIOL 230 Guide,
Copyright © Gary E. Kaiser All Rights Reserved Updated: January, 2011 Please send comments and inquiries to Dr. Gary Kaiser
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What is the Cell Picture Show? A place to showcase striking images in cell, developmental, and molecular biology; a place to learn about cutting-edge research with beautiful images.
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Weinberg A, Jin G, Sieg S and McCormick TS (2012) The Yin and Yang of human beta-defensins in health and disease. Front. Immun. 3:294. doi: 10.3389/fimmu.2012.00294
Rapidly evolving research examining the extended role of human beta-defensins (hBDs) in chemoattraction, innate immune-mediated response, and promotion of angiogenesis suggest that the collective effects of hBDs extend well beyond their antimicrobial mechanism(s)....
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Colorized transmission electron micrograph of human immunodeficiency virus (HIV) particles (blue) budding from the surface of a T cell (a type of lymphocyte).The viruses replicate inside the cell with the different components gathering at the cell membrane to be assembled into new virus particles.
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Colorized transmission electron microscope image of a mast cell full of histamine granules (pink). Histamine is released as part of an allergic reaction. The diameter of the cell is approx. 8.4 micrometers.
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Immunodeficiency disorders occur when the body's immune response is reduced or absent. Immunodeficiency disorders may affect any part of the immune system. Most commonly, these conditions occur when special white blood cells called T or B lymphocytes (or both) do not work as well as they should, or when your body doesn't produce enough antibodies.
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The open access reference on the broad spectrum of brain-immune interactions and their impact on health and disease.
Sleep supports immune defense. In the first half of nocturnal sleep, slow wave sleep (SWS) and the circadian system act in concert to induce a pro-inflammatory milieu, while immunosuppressive mediators are at lowest levels.
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Molecular Movies about: -somatic recombination -MHC class I loading -MHC class II loading -B cell maturation and so on...
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Por Armando Hasudungan http://www.facebook.com/ArmandoHasudungan...
Antigen recognition by T and B cells
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Colección de Materiales Docentes de la UPV en OpenCourseWare: Algunos apartados con mucho material gráfico, otros apartados menos trabajados.
Interesante para profesores y alumnos universitarios
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The pathogenesis of systemic lupus erythematosus—an update Jinyoung Choi1, *,Sang Taek Kim1, *,Joe Craft1, 2, 1 Department of Internal Medicine (Rheumatology), Yale School of Medicine, New Haven, CT 06520, United States2 Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, United States http://dx.doi.org/10.1016/j.coi.2012.10.004,
Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.
The pathogenesis of systemic lupus erythematosus—an update [Current Opinion in Immunology—an update] http://t.co/gKMERgRK...
Gilbert C FAURE's comment,
August 17, 2013 11:26 AM
november 2012, a synthetic review of uptodate hypothesis
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Innate Lymphoid Cell Interactions with Microbiota: Implications for Intestinal Health and Disease Gregory F. Sonnenberg1, , ,David Artis1, 2, , 1 Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA2 Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA http://dx.doi.org/10.1016/j.immuni.2012.10.003
The mammalian intestine harbors trillions of beneficial commensal bacteria that are essential for the development of the immune system and for maintenance of physiologic processes in multiple organs. However, numerous chronic infectious, inflammatory, and metabolic diseases in humans have been associated with alterations in the composition or localization of commensal bacteria that result in dysregulated host-commensal bacteria relationships. The mammalian immune system plays an essential role in regulating the acquisition, composition, and localization of commensal bacteria in the intestine. Emerging research has implicated innate lymphoid cells (ILCs) as a critical immune cell population that orchestrates some of these host-commensal bacteria relationships that can impact immunity, inflammation, and tissue homeostasis in the intestine. This review will discuss reciprocal interactions between intestinal commensal bacteria and ILCs in the context of health and disease.
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What's New in Version 2.0.1 The SHARE function for articles has been restored in this update. Recently released, starting with the Sept. 20th issue, you now have more options to view/manage content:
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T cell tolerance and immunity to commensal bacteria Katherine M Nutsch,Chyi-Song Hsieh Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, United States http://dx.doi.org/10.1016/j.coi.2012.04.009,
Highlights ► Tolerance is required to commensal bacteria and depends on regulatory T cells. ► Regulatory T cells specific to commensal bacteria are generated from naïve T cells in the periphery. ► Bacterial products can facilitate Treg cell function via the induction of IL-10, an immunosuppressive cytokine. ► Specific commensal bacterial species induce inflammatory or tolerogenic T cell responses in the gut.
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Occasional Notes from The New England Journal of Medicine — Chocolate Consumption, Cognitive Function, and Nobel Laureates... Conclusions Chocolate consumption enhances cognitive function, which is a sine qua non for winning the Nobel Prize, and it closely correlates with the number of Nobel laureates in each country. It remains to be determined whether the consumption of chocolate is the underlying mechanism for the observed association with improved cognitive function.
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Video showing HIV-1–infected human macrophage sensing its environment. Images were collected on a spinning disk confocal microscope using a 100X objective. Honorable Mention, 2011 Olympus BioScapes Digital Imaging Competition®.
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Images, Animations, Videos... Any interesting thing for Immunology University Students and/or Lecturers. If you have a nic pic that is not here... feel free of suggest. Thanks. By Alfredo Corell, Universidad de Valladolid (@Virtualf7_0)
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An autoimmune disorder is a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. There are more than 80 different types of autoimmune disorders.
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David Masopust & Vaiva Vezys
Nature 490,41–43 (04 October 2012) doi:10.1038/490041a
Our immune system usually ignores 'friendly' gut bacteria. But when infection with a pathogen damages the intestine's mucosal lining, the resident microbes can invade the body, inducing immune responses directed at themselves.
More on: http://www.nature.com/nature/journal/v490/n7418/full/490041a.html
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