Solid tumors: latest on treaments and research pathways, Page 53

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October 23, 2014 5:07 AM

Brain barrier opened for first time to treat cancer
(www.newscientist.com)

For the first time, doctors have opened and closed the brain's protector – the blood-brain barrier – on demand. The breakthrough will allow drugs to reach diseased areas of the brain that are otherwise out of bounds. Ultimately, it could make it easier to treat conditions such as Alzheimer's and brain cancer.

george sperco's curator insight, February 7, 2023 10:35 AM

good health's curator insight, January 11, 2024 10:06 AM

Acquista Online La Prescrizione Di Perdita Di Peso
Crediamo che i farmaci a volte possano essere molto urgenti da assumere. Se hai urgente bisogno di farmaci, possiamo anche fornirti una consegna espressa,

good health's curator insight, January 11, 2024 10:06 AM

October 20, 2014 3:25 PM

Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma
(informahealthcare.com)

Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma...

No comment yet.

October 17, 2014 4:32 PM

Decreased Survival of Glioma Patients with Astrocytoma Grade IV (Glioblastoma Multiforme) Associated with Long-Term Use of Mobile and Cordless Phones
(www.mdpi.com)

On 31 May 2011 the WHO International Agency for Research on Cancer (IARC) categorised radiofrequency electromagnetic fields (RF-EMFs) from mobile phones, and from other devices that emit similar non-ionising electromagnetic fields, as a Group 2B,...

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October 17, 2014 4:31 PM

GAPVAC Vaccine For Glioblastoma Advances To Clinical Trial
(www.bioprocessonline.com)

immatics biotechnologies and its partner BioNTech AG reported that they are advancing the Glioma Actively Personalized VAccine Consortium (GAPVAC)...

No comment yet.

October 16, 2014 4:36 AM

New target for personalized brain cancer treatment: PTPRZ-MET fusion protein
(www.sciencedaily.com)

A new fusion protein found in approximately 15 percent of secondary glioblastomas or brain tumors has been identified by researchers. The finding offers new insights into the cause of this cancer and provides a therapeutic target for personalized oncologic care.

No comment yet.

October 16, 2014 4:35 AM

Dr Burzynski Successful Treatment of Glioblastoma
(www.youtube.com)

Dr. Stanislaw Burzynski, M.D., PH.D., elaborates on successful treatment of Recurrent Glioblastoma and other forms of cancer at the Burzynski Clinic in Houston, TX. This footage is owned and copyrighted by ADHD Creative, is exclusive to the Diagnosed TV Show and must be noted if used. Samuel Sadler of ADHD Creative Interviewed Dr. Burzynski for use on the Diagnosed TV Show. The Diagnosed TV Show is making an effort to inform Brittany Maynard and anyone else facing Glioblastoma that there is hope. Angels for Shannon has committed to assisting those without sufficient funds to raise funds needed for such treatment.

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October 16, 2014 4:34 AM

New Drug Combinations for Aggresive Brain Cancer Discovered
(www.counselheal.com)

Fuelling the demand for trial is a research from University of Calgary which has shown how a key tumor growth process can be targeted with medication to kill cancer cells and extend life by 30 percent in animals. Glioblastoma or grade IV astrocytoma is a cancer of glial cells in the brain. It is not easy to treat and leaves patients with a mean survival of 15 months, with less than five percent of the patients surviving beyond five years.

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October 15, 2014 5:36 PM

DNAtrix pockets $20M to get its cancer-fighting virus into Phase III
(www.fiercebiotech.com)

The company is developing DNX-2401, a genetically modified adenovirus designed to invade tumor cells while sparing healthy tissues. Once DNX-2401 penetrates its target, it causes cancer cells to rupture, thereby killing them and proliferating itself to infect more tumors, according to DNAtrix.

No comment yet.

October 15, 2014 5:35 PM

University of Calgary research leads to brain cancer clinical trial
(medicalxpress.com)

Researchers used the new therapy to inhibit a pathway in the cancer cells known as mTOR signaling – putting the brakes on this pathway, combined with the current standard therapy, caused more of the cancer cells to die. Scientists are now working with investigators at the NCIC Clinical Trials Group (NCIC-CTG) to start a Canadian clinical trial that may eventually include glioblastoma patients across the country.

No comment yet.

October 14, 2014 11:53 AM

Trials commence on consortium's fully personalized cancer vaccines for glioblastoma
(www.thepharmaletter.com)

A consortium funded by the European Union is to advance a new class of fully personalized cancer vaccines into clinical trials for brain cancer.

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October 12, 2014 1:18 PM

Gene that drives aggressive brain cancer found by new computational approach
(www.sciencedaily.com)

Using an innovative algorithm that analyzes gene regulatory and signaling networks, Columbia University Medical Center (CUMC) researchers have found that loss of a gene called KLHL9 is the driving force behind the most aggressive form of glioblastoma, the most common form of brain cancer. The CUMC team demonstrated in mice transplants that these tumors can be suppressed by reintroducing KLHL9 protein, offering a possible strategy for treating this lethal disease. The study was published today in the online issue of Cell.

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October 10, 2014 11:34 AM

Amazing Letter Tells 29-Year-Old With Brain Cancer Planning to Kill Herself to Reconsider
(www.lifenews.com)

After her diagnosis, Brittany decided that she wanted to move from her California home to Oregon so that she could have access to the “death with dignity” prescription. She plans to die in her home surrounded by her mother, stepfather, husband and best friend.

But, now, in an amazing letter, a woman with a similiar diagnosies has written a touching letter in response.

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October 8, 2014 2:54 AM

A closer look at the blood-brain barrier
(medicalxpress.com)

Thousands of people today have various kinds of stimulators placed deep in their brains in the hope of curing their ills. Many others require systems of tubes, catheters, and shunts penetrating deep into their brain ventricles to deliver chemotherapy, analgesics, or to drain overpressurized cerebral liquids.

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October 7, 2014 4:03 AM

Terminally Ill 29-Year-Old Woman: Why I'm Choosing to Die on My Own Terms
(www.people.com)

Next month Brittany Maynard will end her own life – but not before fighting for the right for others to do the same

No comment yet.

October 7, 2014 4:03 AM

Residual tumor volume and patient survival following reoperation for recurrent glioblastoma
(www.neurocancer.com)

Object Maximal safe tumor resection is part of the standard of care for patients with newly diagnosed glioblastoma. The role of reoperation in the care of patients with recurrent glioblastoma is less clear, and less than a quarter of patients undergo a second surgery. Previous studies have identified preoperative variables associated with the improved survival of patients following reoperation, and guidelines for the selection of patients for reoperation have been devised and validated.

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October 7, 2014 4:01 AM

Bryan Cranston Helped A Fan With Terminal Brain Cancer Complete His Bucket List
(www.buzzfeed.com)

The Breaking Bad star heard about his biggest fan's request to meet him after an online campaign took off. BuzzFeed News spoke to the fan to hear his story.

No comment yet.

October 5, 2014 5:07 PM

Researchers Find Promise in New Treatments for GBM
(neurosciencestuff.tumblr.com)

Glioblastoma multiforme (GBM) is one of the most lethal primary brain tumors, with median survival for these patients only slightly over one year. Researchers at Boston University School of Medicine (BUSM), in collaboration with researchers from the City of Hope, are looking toward novel therapeutic strategies for the treatment of GBM in the form of targeted therapies against a unique receptor, the interleukin-13 receptor α chain variant 2 (IL13Rα2).

No comment yet.

October 5, 2014 9:50 AM

Finding keys to drug therapy resistance in glioblastoma
(www.mycme.com)

Researchers have found one key as to why certain glioblastomas are resistant to drug therapy, and the answer lies in a tumors epigenetic signature.

No comment yet.

October 5, 2014 9:50 AM

FDA grants aldoxorubicin orphan drug status
(www.healio.com)

Hematology Oncology | CytRx Corp. announced that the FDA granted multiple orphan drug designation to aldoxorubicin for the treatment of patients with glioblastoma multiforme, small cell lung cancer and ovarian cancer.Aldoxorubicin is a modified version of the chemotherapeutic agent doxorubicin, combined with a novel single-molecule linker that binds directly and specifically to circulating albumin.

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October 5, 2014 9:49 AM

ASCO Tumor Boards
(university.asco.org)

This is a free case-based activity that includes discussion of a 20 year old male patient with a glioblastoma, presenting with his first relapse after radiation therapy. Along with the patient case, there is a discussion board on ASCO Connection, where users can post comments/questions to each other and to the faculty.

No comment yet.

October 5, 2014 9:48 AM

Radiation Therapy Dose Escalation for Glioblastoma Multiforme in the Era of Temozolomide
(news.doximity.com)

Moderate radiation therapy dose escalation above 60 Gy with concurrent TMZ does not seem to improve clinical outcomes for patients with GBM.

No comment yet.

September 30, 2014 4:33 AM

Strong adverse prognostic impact of hyperglycemic episodes during adjuvant chemoradiotherapy of glioblastoma multiforme
(link.springer.com)

In comparison to normal brain tissue, glioblastomas exhibit significantly increased glucose uptake. Brain edema is a common complication during adjuvant chemoradiotherapy, leading to a requirement for glucocorticoid treatment. Glucocorticoid treatment frequently causes considerable deregulation of blood glucose levels. Therefore, episodes of hyperglycemia may contribute to radio- and/or chemoresistance.

No comment yet.

September 30, 2014 4:32 AM

Epidemiologic and molecular prognostic review of glioblastoma
(www.mdlinx.com)

The authors report the current epidemiology of GBM with new data from the Central Brain Tumor Registry of the United States 2006 to 2010 as well as demonstrate and discuss trends in incidence and survival. They also provide a concise review on molecular markers in GBM that have helped distinguish biologically similar subtypes of GBM and have prognostic and predictive value.

No comment yet.

September 30, 2014 4:31 AM

Current Advances in Radiotherapy for Newly Diagnosed Glioblastoma Multiforme
(twitter.com)

No comment yet.

September 30, 2014 4:31 AM

Hyundai Hope on Wheels grant to advance glioblastoma research at UMMS
(www.umassmed.edu)

Jack L. Leonard, PhD, received a $250,000 grant from Hyundai Hope on Wheels and Worcester-area Hyundai dealers to explore a tumor suppressing pathway that arrests growth and initiates programmed cell death in glioblastoma tumor cells.

No comment yet.

Brain barrier opened for first time to treat cancer (www.newscientist.com)

Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma (informahealthcare.com)

Decreased Survival of Glioma Patients with Astrocytoma Grade IV (Glioblastoma Multiforme) Associated with Long-Term Use of Mobile and Cordless Phones (www.mdpi.com)

GAPVAC Vaccine For Glioblastoma Advances To Clinical Trial (www.bioprocessonline.com)

New target for personalized brain cancer treatment: PTPRZ-MET fusion protein (www.sciencedaily.com)

Dr Burzynski Successful Treatment of Glioblastoma (www.youtube.com)

New Drug Combinations for Aggresive Brain Cancer Discovered (www.counselheal.com)

DNAtrix pockets $20M to get its cancer-fighting virus into Phase III (www.fiercebiotech.com)

University of Calgary research leads to brain cancer clinical trial (medicalxpress.com)

Trials commence on consortium's fully personalized cancer vaccines for glioblastoma (www.thepharmaletter.com)

Gene that drives aggressive brain cancer found by new computational approach (www.sciencedaily.com)

Amazing Letter Tells 29-Year-Old With Brain Cancer Planning to Kill Herself to Reconsider (www.lifenews.com)

A closer look at the blood-brain barrier (medicalxpress.com)

Terminally Ill 29-Year-Old Woman: Why I'm Choosing to Die on My Own Terms (www.people.com)

Residual tumor volume and patient survival following reoperation for recurrent glioblastoma (www.neurocancer.com)

Bryan Cranston Helped A Fan With Terminal Brain Cancer Complete His Bucket List (www.buzzfeed.com)

Researchers Find Promise in New Treatments for GBM (neurosciencestuff.tumblr.com)

Finding keys to drug therapy resistance in glioblastoma (www.mycme.com)

FDA grants aldoxorubicin orphan drug status (www.healio.com)

ASCO Tumor Boards (university.asco.org)

Radiation Therapy Dose Escalation for Glioblastoma Multiforme in the Era of Temozolomide (news.doximity.com)

Strong adverse prognostic impact of hyperglycemic episodes during adjuvant chemoradiotherapy of glioblastoma multiforme (link.springer.com)

Epidemiologic and molecular prognostic review of glioblastoma (www.mdlinx.com)

Current Advances in Radiotherapy for Newly Diagnosed Glioblastoma Multiforme (twitter.com)

Hyundai Hope on Wheels grant to advance glioblastoma research at UMMS (www.umassmed.edu)

Brain barrier opened for first time to treat cancer
(www.newscientist.com)

Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma
(informahealthcare.com)

Decreased Survival of Glioma Patients with Astrocytoma Grade IV (Glioblastoma Multiforme) Associated with Long-Term Use of Mobile and Cordless Phones
(www.mdpi.com)

GAPVAC Vaccine For Glioblastoma Advances To Clinical Trial
(www.bioprocessonline.com)

New target for personalized brain cancer treatment: PTPRZ-MET fusion protein
(www.sciencedaily.com)

Dr Burzynski Successful Treatment of Glioblastoma
(www.youtube.com)

New Drug Combinations for Aggresive Brain Cancer Discovered
(www.counselheal.com)

DNAtrix pockets $20M to get its cancer-fighting virus into Phase III
(www.fiercebiotech.com)

University of Calgary research leads to brain cancer clinical trial
(medicalxpress.com)

Trials commence on consortium's fully personalized cancer vaccines for glioblastoma
(www.thepharmaletter.com)

Gene that drives aggressive brain cancer found by new computational approach
(www.sciencedaily.com)

Amazing Letter Tells 29-Year-Old With Brain Cancer Planning to Kill Herself to Reconsider
(www.lifenews.com)

A closer look at the blood-brain barrier
(medicalxpress.com)

Terminally Ill 29-Year-Old Woman: Why I'm Choosing to Die on My Own Terms
(www.people.com)

Residual tumor volume and patient survival following reoperation for recurrent glioblastoma
(www.neurocancer.com)

Bryan Cranston Helped A Fan With Terminal Brain Cancer Complete His Bucket List
(www.buzzfeed.com)

Researchers Find Promise in New Treatments for GBM
(neurosciencestuff.tumblr.com)

Finding keys to drug therapy resistance in glioblastoma
(www.mycme.com)

FDA grants aldoxorubicin orphan drug status
(www.healio.com)

ASCO Tumor Boards
(university.asco.org)

Radiation Therapy Dose Escalation for Glioblastoma Multiforme in the Era of Temozolomide
(news.doximity.com)

Strong adverse prognostic impact of hyperglycemic episodes during adjuvant chemoradiotherapy of glioblastoma multiforme
(link.springer.com)

Epidemiologic and molecular prognostic review of glioblastoma
(www.mdlinx.com)

Current Advances in Radiotherapy for Newly Diagnosed Glioblastoma Multiforme
(twitter.com)

Hyundai Hope on Wheels grant to advance glioblastoma research at UMMS
(www.umassmed.edu)