CME-CPD

Exploring Nuances Among Targeted and Immune Checkpoint Therapies in Melanoma: Focus on Mechanisms, BRAF Mutation, and Achieving a Durable Response Released On 2/3/2020 Expires On 2/3/2021 Media Type Internet Completion Time 1.0 hour Specialty Dermatology, Hematology-Oncology Topic(s) Oncology Scroll to the Bottom of this Information to Begin this Course This activity is provided by Paradigm Medical Communications, LLC. This activity is supported by an educational grant from Bristol-Myers Squibb. Credit Available Physicians — maximum of 1.0 AMA PRA Category 1 Credit(s)™ NP's — maximum of 1.0 AMA PRA Category 1 Credit(s)™ PA's — maximum of 1.0 AMA PRA Category 1 Credit(s)™ Target Audience This activity has been designed to address the educational needs of community medical oncologists. It will also be of benefit to surgical oncologists, oncology nurses, residents, fellows, nurse practitioners (NPs), PAs, dermatologists, dermatopathologists, and other clinicians who treat patients with melanoma. Program Overview This activity on melanoma treatment will educate oncology clinicians about optimal therapy selection of immune checkpoint inhibitors that will provide durable responses for their patients; reviewing how the mechanisms of action vary from that of targeted therapies; discussing the latest clinical trials that provide clues to nuances between and within these drug classes; as well as demonstrating differences in safety profiles among these current treatments, thus leading to better responses in this patient population. Learning Objectives Upon completion of this activity, participants should be better able to: Review the MOA of immune checkpoint inhibitors and how they differ from those of BRAF–targeted therapies used for the treatment of advanced melanoma Select optimal immunotherapy for patients with advanced melanoma, based on the latest clinical trial data, demonstrating durable response rates as well as nuanced differences between immune checkpoint inhibitors and BRAF-targeted therapies Effectively manage irAEs associated with immune checkpoint inhibitors used in the treatment of advanced melanoma, according to the latest guideline-recommended strategies Faculty Presenter Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Philadelphia, PA Steering Committee Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Philadelphia, PA Ragini R. Kudchadkar, MD Associate Professor Department of Hematology and Medical Oncology Winship Cancer Institute Emory University School of Medicine Atlanta, GA Accreditation Statement Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.   Credit Designation Physician Credit Designation Statement Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. PA Continuing Education PAs may claim a maximum of 1.0 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. Nurse Practitioner Continuing Education The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines. Disclosures of Conflicts of Interest Steering Committee Sanjiv S. Agarwala, MD Retained Consultant: Bristol-Myers Squibb Company; Merck & Co., Inc Ragini R. Kudchadkar, MD Retained Consultant: Array BioPharma Inc.; Bristol-Myers Squibb Company; Immunocore; Novartis Pharmaceuticals Corporation Grant/Research Support: Bristol-Myers Squibb Company; Merck & Co., Inc Paradigm Medical Communications, LLC staff members have no financial relationships to disclose. Independent peer reviewer has no financial relationships to disclose. Independent fellow has no financial relationships to disclose. Instructions for Participation and Credit To receive a CME certificate of participation, you should: Follow instructions to register or log in with your professional information and complete the preactivity assessment View the online activity in its entirety Complete and submit the online posttest and evaluation A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.   For questions regarding CME credit, contact the Paradigm CME Department at (845) 398-5949. There is no fee required for participation in this activity. Hardware and Software Requirements This certified CME activity is designed using HTML5 video. As you navigate the video using the supplied controls, the slides will sync to the speaker. Supported Browsers: For Desktops (Windows/Mac) Microsoft Edge 40 or higher, Firefox 28 or higher, Safari 5.1 or higher, Google Chrome 31 or higher, Opera 21 or higher For Tablets (iPad/Android/Surface) iOS Safari 4 or higher, Android 2.3 or higher, IE Mobile 10 or higher Technical Support: If you have any technical problems or playback issues email us at contactus@paradigmmc.com. Disclosure of Unlabeled Use This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA. Resolution of Conflict of Interest Paradigm Medical Communications, LLC has implemented a system to resolve conflicts of interest for each CME activity to help ensure content is objective, fair and balanced, independent, and aligned with the public interest. Conflicts, if any, are resolved through one or more processes. All CME content in this activity was independently reviewed to ensure that it is free of commercial bias, scientifically rigorous, aligned with the public interest, and compliant with all regulatory guidance and the ACCME’s Standards for Commercial Support of Continuing Medical Education. Disclaimer This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses. 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