Tracy George, MD, ARUP Laboratories, University of Utah, Salt Lake City, UT, discusses unmet needs in systemic mastocytosis, drawing focus on the issue of identifying patients due to the broad range of symptoms they often display.
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Systemic Mastocytosis, Tinnitus etc
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Liposomes are a novel system widely used in the field of drug delivery, gene delivery, medical imaging, and model cell membrane biology.Stealth liposome... 
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Our daily rhythmicity is controlled by a circadian clock with a specific set of genes located in the suprachiasmatic nucleus in the hypothalamus. Mast cells (MCs) are major effector cells that play a protective role against pathogens and inflammation.
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To recognize the relevance of serum tryptase measurement as a useful tool for the diagnosis of allergic diseases and mast cell disorders. Recent da...
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Annular erythema of infancy may be mistaken for systemic mastocytosis due to elevated tryptase levels in babies.
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Neoplastic mast cells expressing CD25 and CD2 can be detected in ascites in patients with advanced systemic mastocytosis and ascites.
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Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental and behavioral disorder with a serious negative impact on the quality of life from childhood until adulthood, which may cause academic failure, family disharmony and even social unrest.
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Evidence in the recent literature suggests that the presentation spectrum of mast cell neoplasms is broad.In this article, we elaborate on recent data pertaining to minor diagnostic criteria of systemic mastocytosis (SM), including sensitive testing methods for detection of activating mutations in...
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Abstract Mastocytosis is a KIT-related myeloproliferative disease characterised by abnormal expansion of neoplastic mast cells (MC) in the skin or virtually any other organ system. The cutaneous fo...
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There is a treatment option for aggressive SM, a subtype of advanced systemic mastocytosis (SM), which is a rare disease caused by abnormal mast cell growth.
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A case series illustrates that systemic mastocytosis (SM) requires a multidisciplinary diagnostic approach for the appropriate clinical management of patients.
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https://onlinelibrary.wiley.com/doi/full/10.1002/clt2.12167 Alba Pérez-Pons, María Jara-Acevedo, Ana Henriques, Paula Navarro-Navarro, Andrés C. García-Montero, Iván Álvarez-Twose, Carlos E. Pedreira, Laura Sánchez-Muñoz, Daniela Damasceno … See all authors Clinical and Translational Immunology,...
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From
mcas
Only recently recognised, mast cell activation syndrome (MCAS) is a large, prevalent collection of illnesses resulting from mast cells (MCs) which are inappropriately activated but which, in contrast to the (collectively rare) forms of mastocytosis, are not significantly proliferating. Due to the diversity of direct and indirect, local and remote effects of the menagerie of mediators released by MCs, likely due to highly heterogeneous sets of mutations in MC regulatory elements, MCAS typically presents as chronic, persistent or recurrent, waxing/waning or slowly progressive, generally inflammatory multisystem polymorbidity. Initial manifestations often occur in childhood but are non-specific; in fact, virtually all of the syndrome’s manifestations are non-specific, leading to decades of mysterious illness complicated by incorrect or superficial diagnoses often poorly responsive to empiric therapies. Diagnosis is further challenged in detecting specific biomarkers of MC activation other than serum tryptase levels, which usually are elevated in systemic mastocytosis but normal in MCAS. MCAS therapy aims to inhibit mediator production/release and block/ ameliorate mediator action. Although patient-specific optimal therapy is not presently predictable, a methodical, persistent, trial-and-error approach usually finds helpful therapy. Lifespan with MCAS approximates normal, but quality of life can be significantly impaired without correct diagnosis and effective treatment.
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Despite the pervasive vaccination program against coronavirus disease 2019 (COVID‐19), people who got fully vaccinated are still contaminated by severe acute respiratory syndrome coronavirus 2, making an effective and safe therapeutic ...
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Summary A 15-year-old pony gelding was presented with a history of dyspnoea with inspiratory and expiratory noise for 1 week. An upper airway respiratory endoscopic examination revealed two trachea...
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In the era of modern medicine, there are still many of us who fall through the cracks. Those with systemic mastocytosis are no strangers to this truth.
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Converging sources of evidence point to a role for inflammation in the development of depression, fatigue and cognitive dysfunction. More precisely, the tryptophan (TRP) catabolism is thought to play a major role in inflammation-induced depression.
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Evidence in the recent literature suggests that the presentation spectrum of mast cell neoplasms is broad. In this article, we elaborate on recent data pertaining to minor diagnostic criteria of systemic mastocytosis (SM), including sensitive testing methods for detection of activating mutations...
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Abstract Anaphylaxis is a clinical emergency which all healthcare professionals need to be able to recognize and manage. The European Academy of Allergy and Clinical Immunology Anaphylaxis multidis...
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https://www.tandfonline.com/doi/full/10.1080/19490976.2022.2105095 Gut Microbes, Volume 14, 2022 - Issue 1. Published online: 29 Jul 2022 Chiko Shimbori, Giada De Palma, Lauren Baerg, Jun Lu, Elena F.
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Living with systemic mastocytosis (SM) can have a number of impacts on a patient's physical health, relationships, and emotional status.
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Read Cogent Biosciences (NASDAQ:COGT) Posts Quarterly Earnings Results, Misses Expectations By $0.06 EPS at Modern Readers...
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https://www.jaci-inpractice.org/article/S2213-2198(22)00587-6/fulltext The Journal of Allergy and Clinical Immunology: In Practice, Published: June 17, 2022. DOI: https://doi.org/10.1016/j.jaip.2022.05.036 Karl Sotlar, M.D., Tracy I.
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