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Scoop.it!
FDA panel will discuss switch to an annual booster in the fall, akin to flu vaccination strategy Via HAS-veille 
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Scoop.it!
Despite early reports to the contrary, there is increasing evidence that patients with severe COVID-19 have a robust type I interferon response, which contrasts with the delayed, possibly suppressed, interferon response seen early in infection. A robust type I interferon response could exacerbate hyperinflammation in the progression to severe COVID-19 through diverse mechanisms. Further understanding of the roles of type I interferon at different stages of infection and in patients with mild versus severe COVID-19 will provide insights for the therapeutic use of interferon administration or JAK inhibitors in patients with COVID-19. In this Comment, Jeong Seok Lee and Eui-Cheol Shin discuss contradictory results regarding the downregulation or upregulation of type I interferon responses in patients with COVID-19 and the implications for therapies that target this pathway. Via HAS-veille
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Scoop.it!
Vaccines directed against SARS-CoV-2 have been administered to healthy volunteers and have been shown to stimulate a brisk humoral and cellular immune response. All vaccines were generally well tolerated with mostly mild to moderate local and systemic reactions. Via HAS-veille
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Some researchers believe nasal vaccines, which aim to induce mucosal immunity, might guard against infection. Thålin has found some intriguing clues in a study that has carefully documented vaccinations and infections in 2000 health care workers in Sweden since April 2020. In September 2022, she and her colleagues reported that people who were infected early in the pandemic, before they were vaccinated, had detectable levels of SARS-CoV-2–specific antibodies of a type named IgA in their noses. The antibodies were not seen in a vaccine-only group. Thålin thinks nasal vaccines would be more effective than current shots at stimulating such antibodies, which might block COVID-19 infections right where they start, in the respiratory tract.
Gommerman is intrigued by the potential for IgA antibodies in the nose and saliva as well. Right now, which level of IgA is an effective shield against infection is still unclear, she says, but “scientists are coming together to figure this out.”