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Institute for Bioengineering and Biosciences
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Comparative Evolutionary Patterns of Burkholderia cenocepacia and B. multivorans During Chronic Co-infection of a Cystic Fibrosis Patient Lung

Comparative Evolutionary Patterns of Burkholderia cenocepacia and B. multivorans During Chronic Co-infection of a Cystic Fibrosis Patient Lung | iBB | Scoop.it

During chronic respiratory infections of cystic fibrosis (CF) patients, bacteria adaptively evolve in response to the nutritional and immune environment. A research paper from iBB-BSRG researchers, just published in Frontiers in Microbiology (part of the Research Topic: Evolutionary Mechanisms of Infectious Diseases), contributes to the understanding of shared and species specific evolutionary patterns of B. cenocepacia and B. multivorans evolving in the same CF lung environment. Results support the idea that positive selection might be driven by the action of the host immune system, antibiotic therapy and low oxygen and iron concentrations. This research work, coordinated by Prof. Isabel Sá-Correia, results from the PhD thesis in Biotechnology and Biosciences (BIOTECnico program) of A. Amir Hassan. Dr. AA Hassan is currently working at the Laboratory of Microbiology, Department of Biochemistry and Microbiology, Ghent University, Belgium.

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New Review on Yeast Toxicogenomics

New Review on Yeast Toxicogenomics | iBB | Scoop.it

The 2015 edition of the special issue Environmental Biotechnology published by Current Opinion in Biotechnology features a review on the field of yeast toxicogenomics, focusing on the role of this organism both as a cell model and as a cell factory. Toxicogenomics has emerged in the past decade as a transdisciplinary area that merges genome-wide methodologies with traditional toxicology studies to provide an integrated assessment of the cellular response to different toxicants at multiple levels. The invitation to write this review was made on the basis of the longstanding contribution of the Biological Sciences Research Group-iBB and its PI Isabel Sá-Correia to this field.
The still highly relevant role of yeast as a model organism is highlighted in this review, supported by the pioneering exploitation of multiple Omics approaches (genomics, proteomics, metabolomics, transcriptomics, lipidomics...) and synthetic biology, in fields ranging from the pharmaceutical industry to food preservation processes and identification of toxicological outcomes of exposure to environmental toxicants and agrochemicals. The review also describes the most recent advances in the production of next-generation biofuels based on renewable feedstocks such as lignocellulosic hydrolysates. Yeast is a cell factory of choice in biorefineries, where genomic and metabolic engineering are greatly contributing to develop more cost-efficient bioprocess conditions and more robust engineered strains. Click on the title to learn more.

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