iBB
46.4K views | +5 today
Follow
iBB
Institute for Bioengineering and Biosciences
Curated by iBB
Your new post is loading...
Your new post is loading...
Scoop.it!

Modeling the Full Metabolism of the Human Pathogen Candida parapsilosis

Modeling the Full Metabolism of the Human Pathogen Candida parapsilosis | iBB | Scoop.it

Understanding the behavior of human pathogens is both a challenge and a need, if we are to address infectious diseases with the best possible tools. Genome-scale metabolic models are a way to meet this task, which was just used for the second most prevalent Candida species in Europe, Candida parapsilosis. The construction and validation of a global stoichiometric model describing the whole metabolic network in this human pathogen, as well as its exploitation in drug target discovery, stemming from a collaboration between researchers from BSRG/iBB (Miguel Cacho Teixeira), ITQB-NOVA (Isabel Rocha) and CEB-UMinho (Óscar Dias), was just published in Genes.

No comment yet.
Scoop.it!

Exploring N.C.Yeastract to Study Gene and Genomic Regulation in Non Conventional Yeasts

Exploring N.C.Yeastract to Study Gene and Genomic Regulation in Non Conventional Yeasts | iBB | Scoop.it

Responding to the recent interest of the yeast research community in non-Saccharomyces cerevisiae species of biotechnological relevance, the N.C.Yeastract was associated to YEASTRACT+, a curated repository of known regulatory associations between transcription factors (TFs) and target genes in yeasts. A recent Minireview published in FEMS Yeast Research aims to advertise the update of the existing information since the release of N.C.Yeastract in 2019, and to raise awareness in the community about its potential to help the day-to-day work on non-Saccharomyces species, exploring all the information and bioinformatics tools available in YEASTRACT +. Using simple and widely used examples, a guided exploitation is offered. The usage potentialities of the new CommunityYeastract platform by the yeast community are also discussed. The Minireview is coauthored by a BSRG-iBB team coordinated by Isabel Sá-Correia and including Cláudia P. Godinho, Margarida Palma, Miguel C. Teixeira and the PhD students Miguel Antunes and Marta N. Mota, in collaboration with INESC-ID colleagues.

No comment yet.
Scoop.it!

Controlling Biofilm Establishment Since the First Touch

Controlling Biofilm Establishment Since the First Touch | iBB | Scoop.it

Candida glabrata’s ability to cause human infections is tightly linked to its impressive ability to form persistent biofilms. The molecular control of this process is far from being clarified, as it lacks many of the typical features displayed by other Candida species. In this study, a combination of genetic screening, RNA-seq based transcriptomics, and Single-Cell Force Spectroscopy (SCFS), enabled the observation that the transcription factor CgEfg1, but not CgTec1, is necessary for the initial interaction of C. glabrata cells with both abiotic surfaces used in medical devices and epithelial cells, while both transcription factors orchestrate biofilm maturation. The knowledge gathered through this study by former PhD student Mafalda Cavalheiro, and an international team led by Miguel Cacho Teixeira, BSRG-iBB, including Etienne Dague, LAAS-CNRS, Geraldine Butler, University College Dublin, and Arsénio Fialho, BSRG-iBB, and just published in Communications Biology, is expected to contribute to guide the design of more successful therapeutic approaches.

No comment yet.
Scoop.it!

Development of Anti-Fouling Materials that Reduce Microbial Pathogen Adhesion

Development of Anti-Fouling Materials that Reduce Microbial Pathogen Adhesion | iBB | Scoop.it

The attachment of bacteria and other microbes to natural and artificial surfaces leads to the development of biofilms, which can further cause nosocomial infections. Thus, an important field of research is the development of new materials capable of preventing the initial adhesion of pathogenic microorganisms. In this work, novel polymer/particle composite materials were developed and characterized with respect to their mechanical, chemical and surface properties. Both S. aureus and C. glabrata exhibit a reduced capacity to adhere to the newly developed nanomaterials used in this study, thus showing their potential for bio-medical applications. This study, led by researchers from LAAS-CNRS, Toulouse, and co-authored by Mafalda Cavalheiro and Miguel Cacho Teixeira from BSRG-iBB, was just published in Nanomaterials.

No comment yet.
Scoop.it!

Oxidative Stress Response Pathway Promotes Virulence

Oxidative Stress Response Pathway Promotes Virulence | iBB | Scoop.it

Candida glabrata’s ability to cause persistent human infections is tightly linked to its impressive ability to overcome host immune system defenses. The molecular basis of virulence in this pathogen are far from being clarified, as it lacks many of the typical pathogenesis features displayed by other Candida species. In this study, the transcription factor Tog1 was found to play a key role in the transcriptome-wide response to oxidative stress, enabling higher proliferation upon phagocytosis and increased virulence. The knowledge gathered through this study, by an international team led by Miguel Cacho Teixeira, BSRG-iBB, and just published in Virulence, is expected to contribute to guide the design of more successful therapeutic approaches.

No comment yet.
Scoop.it!

A Promising Platform for Drug Target Prediction in C. albicans

A Promising Platform for Drug Target Prediction in C. albicans | iBB | Scoop.it

New drugs are highly needed to treat human candidiasis. The ability to find interesting new drug targets is now expanded by the construction and validation of a global stoichiometric model describing the whole metabolic network in the human pathogen Candida albicans. This application of Systems Biology to tackle pathogenesis is highly innovative, and stems from a collaboration between researchers from BSRG/iBB (Miguel Cacho Teixeira), ITQB-NOVA (Isabel Rocha) and CEB-UMinho (Óscar Dias). The description of this model and of its potential have just been published in Journal of Fungi.

No comment yet.
Scoop.it!

New Pathway Controlling Azole Resistance in Candida glabrata

New Pathway Controlling Azole Resistance in Candida glabrata | iBB | Scoop.it

The ability to acquire azole resistance is an emblematic trait of the fungal pathogen Candida glabrata. Understanding the molecular basis of azole resistance in this pathogen is crucial to design more suitable therapeutic strategies. In this study, the transcription factor Rpn4 was found to play a key role in the transcriptome-wide response to fluconazole. Rpn4 is described a new regulator of the ergosterol biosynthesis pathway in C. glabrata, contributing to plasma membrane homeostasis, decreasing azole drug accumulation and, thus, conferring azole resistance. These results  obtained by an international team led by Miguel Cacho Teixeira, BSRG-iBB, just published in Antimicrobial Agents and Chemotherapy, are expected to contribute to maintain the usability of this drug in antifungal therapy.

televisionstand463@gmail.com's curator insight, July 1, 2020 12:53 PM
https://timkush.com/
https://timkush.com/product/buy-london-pound-cake-online/
https://timkush.com/product/buy-gary-payton-cookies-online/
https://timkush.com/product/buy-runtz-carts-online/
https://timkush.com/product/buy-alpine-vapor-vape-pens-online/
https://timkush.com/product/buy-cotton-candy-dank-vapes-full-gram-cartridge/
https://timkush.com/product/buy-la-confidential-dank-vapes-full-gram-cartridge/
https://timkush.com/product/dank-vapes/
https://timkush.com/product/buy-white-widow-online/
https://timkush.com/product/buy-muha-meds-carts-online/
https://timkush.com/product/master-kush/
https://timkush.com/product/gorilla-glue-4/
https://timkush.com/product/gods-gift/
https://timkush.com/product/buy-lemon-tree-online/
https://timkush.com/product/afghan-kush/
https://timkush.com/product/buy-uk-cheese-online/
https://timkush.com/product/buy-do-si-dos-online/
https://timkush.com/product/girl-scout-cookies/
https://timkush.com/product/buy-lucky-charms-online/
https://timkush.com/product/buy-big-smokey-farms-tins-online/
https://timkush.com/product/buy-sexxpot-online/
https://timkush.com/product/buy-raw-garden-live-resin-cartridge/
https://timkush.com/product/blue-cookies/
https://timkush.com/product/pineapple-express/
https://timkush.com/product/buy-moon-rocks-online/
https://timkush.com/product/blue-dream/
https://timkush.com/product/buy-jungle-boys-online/
https://timkush.com/product/buy-710-kingpen-carts/
https://timkush.com/product/ak-47/
https://timkush.com/product/purchase-alaskan-thunder-fuck/
https://timkush.com/product/buy-brass-knuckles-vape-cartridges-online/
https://timkush.com/product/bubba-kush/
https://timkush.com/product/buy-backwoods-cigars/
https://timkush.com/product/buy-barewoods-online/
https://timkush.com/product/buy-blackberry-kush/
https://timkush.com/product/buy-blueberry-online/
https://timkush.com/product/buy-bruce-banner-strain/
https://timkush.com/product/buy-chemdawg-online/
https://timkush.com/product/buy-bloom-vape-cartridge-online/
https://timkush.com/product/buy-brass-knuckles-carts/
https://timkush.com/product/buy-cali-carts-online/
https://timkush.com/product/buy-cereal-carts-online/
https://timkush.com/product/buy-chronic-carts-online/
https://timkush.com/product/buy-cobra-extracts-online/
https://timkush.com/product/buy-cookies-carts-online-2/
https://timkush.com/product/buy-exotic-carts/
https://timkush.com/product/buy-glo-extracts-online/
https://timkush.com/product/buy-khalifa-kush-online/
https://timkush.com/product/buy-biscotti-weed-online/
https://timkush.com/product/buy-smart-bud-online/
https://timkush.com/product/buy-space-monkey-meds-online/
https://timkush.com/product/fire-og/
https://timkush.com/product/og-kush/
https://timkush.com/product/skywalker/
https://timkush.com/product/sfv-og/
https://timkush.com/product/tahoe-og-kush/
https://timkush.com/product/paris-og/
https://timkush.com/product/buy-plug-and-play-cartridge/
https://timkush.com/product/buy-heavy-hitters-online/
https://timkush.com/product/supreme-vape/
https://timkush.com/product/buy-kurvana-cartridges-online/
https://timkush.com/product/buy-palmas-cartridge-online/
https://timkush.com/product/soul-remedy-extract/
https://timkush.com/product/buy-cali-gold-extracts-online/
https://timkush.com/product/buy-mario-carts-online/
https://timkush.com/product/buy-kingpen-cartridge-online/
https://timkush.com/product/buy-litxtracts-cartridges-online/
https://timkush.com/product/buy-tko-carts-online/
https://timkush.com/product/buy-razzle-dazzle-clear-carts-online/
https://timkush.com/product/buy-west-coast-cure-carts-online/
https://timkush.com/product/buy-blueberry-muffin-dank-vapes-online/
https://timkush.com/product/durban-poison/
https://timkush.com/product/gorilla-glue/
https://timkush.com/product/sour-diesel/
https://timkush.com/product/buy-ghost-train-haze/
https://timkush.com/product/purple-kush/
https://timkush.com/product/gelato-41-2/
https://timkush.com/product/buy-gushers-online/
https://timkush.com/product/buy-haze-buy-haze-online/
https://timkush.com/product/buy-g-13-online/
https://timkush.com/product/tangie/
https://timkush.com/product/buy-trainwreck-buy-trainwreck-strain/
https://timkush.com/product/buy-magic-pipe-vape/
https://timkush.com/product/cbd-living-vape/
https://timkush.com/product/buy-runtz-online/
https://timkush.com/product/buy-hindu-kush/
https://timkush.com/product/buy-northern-lights/
https://timkush.com/product-category/flowers/flowers-indica/page/2/
https://timkush.com/product/buy-super-silver-haze/
https://timkush.com/product/buy-dankwoods-online/
https://timkush.com/product/buy-gaswoods-online/
https://timkush.com/product/dr-zodiaks-moonrock- cartridge/
Scoop.it!

Romeu Viana Receives Best Poster Award at MicroBiotec19

Romeu Viana Receives Best Poster Award at MicroBiotec19 | iBB | Scoop.it

Romeu Viana, PhD student from the AEM program in Applied and Environmental Microbiology, won one of the best poster prizes at the Congress of Microbiology and Biotechnology – Microbiotec19, held on December 5-7, in Coimbra, Portugal, with a communication entitled “Genome-scale metabolic model of the human pathogen C. albicans: aiming the identification of promising new drug targets”. The work stems from a collaboration between researchers from BSRG/iBB (Romeu Viana, Mónica Galocha), under the supervision of Miguel Cacho Teixeira, and researchers from CEB-UMinho (Óscar Dias, José Bastos, Davide Lagoa) and ITQB-NOVA (Isabel Rocha).

No comment yet.
Scoop.it!

Pedro Pais to Defend PhD Thesis in Biotechnology and Biosciences

Pedro Pais to Defend PhD Thesis in Biotechnology and Biosciences | iBB | Scoop.it

Pedro Henrique Magalhães Fernandes Pais will be defending his PhD thesis in Biotechnology and Biosciences at Instituto Superior Técnico, friday the 27th september 2019 (10:00 H, room PA-3). During the last years, and under the supervision of Miguel Teixeira from BSRG-iBB, Pedro studied the intricacies of the regulatory network that controls drug resistance in the fungus Candida glabrata. The title of his thesis is "Unveiling the complex regulatory network governing antifungal drug resistance in Candida glabrata: from new regulators to new effectors".

No comment yet.
Scoop.it!

Following the Evolution Towards Fluconazole Resistance in C. glabrata

Following the Evolution Towards Fluconazole Resistance in C. glabrata | iBB | Scoop.it

The effectiveness of Candida glabrata as an emerging human pathogen relies on its ability to acquire azole drug resistance. In a paper just published in Antimicrobial Agents and Chemotherapy, the first time-course evaluation of the global gene expression changes that lead a drug susceptible C. glabrata clinical isolate to step-wise acquisition of resistance to azole drugs was conducted. This work, which results from the collaboration of six different teams under the coordination of Miguel C Teixeira from BSRG-iBB, highlights the multifactorial nature of azole resistance acquisition, including the Epa3 adhesin as a new player, while providing fascinating clues on the underlying evolutionary path. This knowledge is of crucial importance to design more effective antifungal therapy.

No comment yet.
Scoop.it!

Mixed Regulatory-Metabolic Genome-Scale Models in Yeasts

Mixed Regulatory-Metabolic Genome-Scale Models in Yeasts | iBB | Scoop.it

The project "MIXED-UP: Targeting pathogenesis and engineering cell factories: developing mixed regulatory-metabolic genome-scale models in yeasts" has been recommended for funding by FCT (2017 Call for SR&TD Project Grants). The goal of MIXED-UP is to develop genomic scale mathematical models that describe the complete metabolic and regulatory networks in yeasts of biotechnological and clinical relevance. These mathematical models will be used for the in silico prediction of the best proteins or pathways to target for the development of improved yeast cell factories. They will also enable the identification of the key regulatory or metabolic steps that constitute the best drug targets, aiming the development of new antifungal drugs for the treatment of superficial and invasive candidiasis. The project, which falls within the scientific area of Industrial Biotechnology, is headed by Miguel Teixeira from BSRG-iBB and involves a consortia of partners from the University of Minho, INESC-ID and IGC.

No comment yet.
Scoop.it!

Determining Virulence in Candida glabrata Through Adaptation to Host Stress

Determining Virulence in Candida glabrata Through Adaptation to Host Stress | iBB | Scoop.it

Persistence and virulence of Candida glabrata infections are multifactorial phenomena, whose understanding is crucial for infection erradication. In this study, the multidrug transporter CgDtr1 was found to be a plasma membrane acetic acid exporter, relieving the stress induced upon C. glabrata cells within hemocytes, and thus enabling increased proliferation and virulence against G. mellonella larvae. These results, emerging from a collaboration between BSRG members and led by Miguel Cacho Teixeira, were just published in Frontiers in Cellular and Infection Microbiology and are expected to contribute to design more suitable therapeutic strategies. Click on title to learn more.

No comment yet.
Scoop.it!

Yeast Response and Tolerance to Benzoic Acid Involves the Multidrug/Multixenobiotic Resistance Transporter Tpo1

Yeast Response and Tolerance to Benzoic Acid Involves the Multidrug/Multixenobiotic Resistance Transporter Tpo1 | iBB | Scoop.it

Benzoic acid is a widely-used food preservative. The efficacy of its action is compromised by the ability of spoilage yeasts to tolerate its toxic effects. In a paper recently published in the journal Applied Microbiology and Biotechnology, the PhD student Cláudia Godinho and a team coordinated by Prof. Isabel Sá-Correia, from BSRG-iBB, describe the involvement of the Saccharomyces cerevisiae multidrug transporter Tpo1 in yeast tolerance to benzoic acid. The study further unveiled the regulatory network behind Tpo1 transcription activation upon benzoic acid exposure. Collectively, results suggest Tpo1 as one of the key players standing in the crossroad between benzoic acid stress response and tolerance and the control of the intracellular concentration of nitrogenous compounds in yeast. Click on title to learn more.

No comment yet.
Scoop.it!

A Neofunctionalized Transcription Factor Controls Azole Resistance in C. glabrata

A Neofunctionalized Transcription Factor Controls Azole Resistance in C. glabrata | iBB | Scoop.it

The prevalence of antifungal resistance in Candida glabrata, especially against azole drugs, results in difficult-to-treat and potentially life-threatening infections. In this study, the role of a newly described transcription factor, Mar1, in azole susceptibility was explored. Using RNA-sequencing, its role in the transcriptome-wide response to fluconazole is assessed, leading to the elucidation of its role in modulating azole susceptibility, dependent on membrane sphingolipid incorporation, membrane permeability, and intracellular drug accumulation. Altogether, a regulatory pathway modulating azole susceptibility in C. glabrata is proposed, resulting from what appears to be a neofunctionalization of a Hap1-like transcription factor. These results obtained by an international team led by Miguel Cacho Teixeira, BSRG-iBB, just published in Journal of Fungi, are expected to contribute to maintain the usability of this drug in antifungal therapy.

No comment yet.
Scoop.it!

Prediction of the Haa1-regulatory Network in the Oleaginous Yeast Rhodotorula toruloides

Prediction of the Haa1-regulatory Network in the Oleaginous Yeast Rhodotorula toruloides | iBB | Scoop.it

A new bioinformatics tool, developed by our computational biologist collaborators at INESC-ID, is described in a recent article published in BMC Bioinformatics. The BSRG-iBB team contributed to the application of the tool to predict the putative Haa1-regulon in the lipid producing yeast cell factory Rhodotorula toruloides. For this, genomic information on this species was collected and included in the CommunityYeastract to benefit from the access to all the comparative genomics queries offered in the YEASTRACT + portal. The transcription factor Haa1 is the main regulator of S. cerevisiae genomic response to acetic acid stress, regulating, directly or indirectly, the majority of acetic acid tolerance genes. The prediction of RtHaa1-regulon has an expected impact in the optimization of R. toruloides robustness for biorefinery processes using hydrolysates from lignocellulosic residues. The BSRG-iBB team involved in these studies included the PhD student Miguel Antunes, his supervisor Isabel Sá-Correia, and Cláudia P. Godinho and Miguel C. Teixeira. 

No comment yet.
Scoop.it!

AntiMicrobial Peptide Resistance Conferred by a Polyamine Transporter: a New Virulence Mechanism

AntiMicrobial Peptide Resistance Conferred by a Polyamine Transporter: a New Virulence Mechanism | iBB | Scoop.it

Cellular components that contribute to both pathogenesis and drug resistance are among the most promising drug targets in human pathogens. In this study, the uncharacterized drug:H+ antiporter CgTpo4 was shown to play a role in Candida glabrata virulence in the infection model G. mellonella. The underlying mechanism was demonstrated to include a role in AntiMicrobial Peptide (AMP) resistance, compatible with the observed immune response deployed by G. mellonella upon C. glabrata infection. These results, emerging from a collaboration between BSRG members, led by Miguel Cacho Teixeira and including Arsénio Fialho and Dalila Mil-Homens, were just published in International Journal of Molecular Sciences and are expected to contribute to design more suitable antifungal therapeutic strategies.

No comment yet.
Scoop.it!

What Makes S. boulardii probiotic? A Transcriptomics View

What Makes S. boulardii probiotic? A Transcriptomics View | iBB | Scoop.it

Saccharomyces boulardii has been widely used, for more than 50 years, as a human probiotic. Nonetheless, the molecular basis underlying its mode of action is scarcely understood. In this study, global gene expression analysis, resorting to Illumina- based RNA-sequencing, was conducted to analyze differential gene expression patterns in S. cerevisiae and S. cerevisiae var. boulardii in GI- tract like medium. Additionally, based on the construction of an S. cerevisiae var. boulardii database, a global comparison between gene promoter sequences in S. cerevisiae and S. cerevisiae var. boulardii strains was conducted. The obtained results shed light into the molecular basis of the differential probiotic phenotypes displayed by these two closely related yeasts. The knowledge gathered through this study, by a team led by Miguel Cacho Teixeira, BSRG-iBB, and Pedro T Monteiro, INESC-ID, and just published in Genomics, is expected to contribute to guide the design of more rationale, probiotic-based, therapeutic approaches.

No comment yet.
Scoop.it!

Global Evaluation of S. cerevisiae Regulatory Network: Challenging Previous Concepts

Global Evaluation of S. cerevisiae Regulatory Network: Challenging Previous Concepts | iBB | Scoop.it

Understanding the rules that govern complex transcriptional regulation has been attempted for many years. In this study, the full network of transcriptional regulatory associations currently known for Saccharomyces cerevisiae, as gathered in the latest release of the YEASTRACT database, was topologically evaluated. Overall, our analyses challenge previous results, pointing out towards the paucity of experimental evidence to support theories. This study, that stems from a collaboration between researchers from BSRG/iBB (Miguel Cacho Teixeira), INESC-ID (Pedro Monteiro) and IGC (Claudine Chaouiya), was just published in Scientific Reports.

No comment yet.
Scoop.it!

Mafalda Cavalheiro to Defend PhD Thesis in Biotechnology and Biosciences

Mafalda Cavalheiro to Defend PhD Thesis in Biotechnology and Biosciences | iBB | Scoop.it

Mafalda Banazol de Santa Rita Cavalheiro will be defending her PhD thesis in Biotechnology and Biosciences at Instituto Superior Técnico, Monday the 12th of October 2020, at 2pm (https://videoconf-colibri.zoom.us/j/97930626637). During the last years, and under the supervision of Miguel Cacho Teixeira from BSRG-iBB, Mafalda studied molecular and biophysical properties that enable the fungal pathogen Candida glabrata to cause recalcitrant life threatening infections, based on its ability to evolve towards a drug resistance phenotype or to establish stable biofilms. The title of her thesis is “Deciphering Mechanisms of Pathogenesis in Candida glabrata: in the Crossroad Between Drug Resistance and Virulence”.

No comment yet.
Scoop.it!

Dual Role in Drug Resistance and Biofilm Formation Played by a Family of Proteins in the Human Pathogen Candida glabrata

Dual Role in Drug Resistance and Biofilm Formation Played by a Family of Proteins in the Human Pathogen Candida glabrata | iBB | Scoop.it

Cellular components that contribute to both pathogenesis and drug resistance are among the most promising drug targets in human pathogens. In this study, the drug:H+ antiporter family of drug efflux pumps in Candida glabrata was screened for a role in biofilm formation. Four out of ten were shown to be required for the triggering of adhesion and biofilm formation, by controlling plasma membrane potential through the transport of charged molecules, thus affecting the perception of nutrient availability. These results, emerging from a collaboration between BSRG members and Hiroji Chibana’s Lab, MMRC, Chiba Univ, Japan, and led by Miguel Cacho Teixeira, were just published in Frontiers in Cellular and Infection Microbiology and are expected to contribute to design more suitable antifungal therapeutic strategies.

 

Image details: Candida glabrata, BCarver1 at en.wikipedia / Public domain

No comment yet.
Scoop.it!

The YEASTRACT+ Portal is Released!

The YEASTRACT+ Portal is Released! | iBB | Scoop.it

The YEASTRACT+ information system (http://YEASTRACT-PLUS.org/) is a wide-scope computational tool for the analysis and prediction of transcription regulatory associations at the gene and genomic levels in 10 yeast species of biotechnological or human health relevance. A large team led by Isabel Sá-Correia, Miguel Teixeira, from iBB, and Pedro Monteiro, from INESC-ID, has just released this new web-portal in the 2020 Nucleic Acids Research Database Issue and is compromised to continue its efforts to expand this resource, which is currently supported within the context of the Biodata.pt/Elixir.pt Research Infrastructure.

No comment yet.
Scoop.it!

Mónica Galocha Receives Best Poster Award at HFP2019

Mónica Galocha Receives Best Poster Award at HFP2019 | iBB | Scoop.it

Mónica Galocha, PhD student from the PhD program AEM-Applied Environmental Microbiology, won one of the PhD poster prizes awarded at the eight FEBS Advance Lecture Course on Human Fungal Pathogens-Molecular Mechanisms of Host-Pathogen Interactions and Virulence, held on May 18-24, in La Colle sur Loup, France, with a communication entitled “Candida glabrata evolution towards posaconazole resistance irrespective of PDR1 GOF mutations”. The work results from a collaboration between researchers from BSRG-iBB (Miguel Cacho Teixeira), University of Porto (Acácio G. Rodrigues) and Chiba University (Hiroji Chibana).

No comment yet.
Scoop.it!

Cláudia Godinho Defends PhD Thesis in Biotechnology and Biosciences

Cláudia Godinho Defends PhD Thesis in Biotechnology and Biosciences | iBB | Scoop.it

Cláudia Sofia Pires Godinho will be defending her Ph D thesis in Biotechnology and Biosciences at Instituto Superior Técnico, thursday the 26th July 2018 (10:30 H, room PA3). During the last years, and under the supervision of Profs. Isabel Sá-Correia and Miguel Teixeira from BSRG-iBB, Cláudia has investigated the role of transporters in yeast multistress defense mechanisms. The title of her thesis is "ABC and MFS transporters involved in multistress defense mechanisms in the model eukaryote Saccharomyces cerevisiae: roles of Pdr18 and Tpol”.

No comment yet.
Scoop.it!

Mafalda Cavalheiro Receives Best Poster Award at MicroBiotec17

Mafalda Cavalheiro Receives Best Poster Award at MicroBiotec17 | iBB | Scoop.it
Mafalda Cavalheiro, PhD student from the PhD program in Biotechnology and Biosciences, has won one of the best poster prizes at the Congress of Microbiology and Biotechnology – Microbiotec17, held on December 7-9, in Porto, Portugal, with a communication entitled “Determining virulence by protecting the cell from host induced stresses: the unexpected role of C. glabrata multidrug transportes”. The work stems from a collaboration between researchers from BSRG/iBB (Rui Santos, Daniela Romão, Dalila Mil-Homens, Pedro Pais, Catarina Costa, Romeu Viana, Susana Santos and Arsénio M Fialho), under the supervision of Miguel Cacho Teixeira.
No comment yet.
Scoop.it!

Miguel Cacho Teixeira Obtains Habilitation in Biotechnology and Biosciences

Miguel Cacho Teixeira Obtains Habilitation in Biotechnology and Biosciences | iBB | Scoop.it
Miguel Cacho Teixeira, from BSRG-iBB and the Department of Bioengineering of IST, got his Habilitation (Agregação) in Biotechnology and Biosciences at Instituto Superior Técnico, University of Lisbon. Public defense took place in the 14th and 15th of September 2017, including the defense of a Curricular Unit entitled “Functional and Comparative Genomics” and a lecture entitled “Using Molecular Systems Biology approaches to decipher antifungal drug resistance mechanisms in Candida glabrata”.
No comment yet.