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Institute for Bioengineering and Biosciences
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A CBM-Hexapeptide Fusion Confers Antimicrobial Properties to Cellulose

A CBM-Hexapeptide Fusion Confers Antimicrobial Properties to Cellulose | iBB | Scoop.it

A new strategy to modify cellulose with the short antimicrobial hexapeptide MP196 (RWRWRW-NH2) is proposed by BERG and BSIRG researchers that uses fusions of Cys-terminated derivatives of MP196 and a carbohydrate binding module (CBM). CBM3-MP196-modified cellulose hydrogels displayed antibacterial activity that was significantly higher when compared with controls. This versatile concept offers a toolbox for the functionalization of different cellulose materials with a broad choice in peptides. the paper was published in Acta Biomaterialia. The work was funded by project CBM-X.

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Mariana Barbosa Joins CBM-X Team as Research Scientist

Mariana Barbosa Joins CBM-X Team as Research Scientist | iBB | Scoop.it

Mariana Barbosa has joined the team of the FCT-funded project "CBM-X: Biorecognition as a Tool for the Functionalization of Cellulose-based Materials with Biomolecules and Nanostructures". During the next three years Mariana will be responsible for the development of bi-functional biomolecular constructs combining Carbohydrate Binding Modules (CBMs) with valuable biological partners that allow the modification of cellulose with nanomaterials or biomolecules in a controlled way. The project is a joint collaboration between BERG-iBB (Miguel Prazeres) and the portuguese company NZYTech.

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Functionalization of Cellulose Hydrogels with Carbohydrate-Binding Module Fusions

Functionalization of Cellulose Hydrogels with Carbohydrate-Binding Module Fusions | iBB | Scoop.it

Materials with novel and enhanced functionalities can be obtained by modifying cellulose with a range of biomolecules. In a recent paper published in Materials, Mariana Barbosa, Hélvio Simões and Miguel Prazeres from BERG-iBB describe the modification of cellulose hydrogels using bi-functional biomolecular constructs based on carbohydrate binding modules (CBMs). The binding of CBM fusions, the capture of antibodies and the grafting of oligonucleotides onto hydrogels was successfully demonstrated. The CBM-based platform could contribute significantly to the development of advanced medical diagnostic sensors or specialized biomaterials, among others. The work was funded by project CBM-X.

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