iBB
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iBB
Institute for Bioengineering and Biosciences
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Controlling Biofilm Establishment Since the First Touch

Controlling Biofilm Establishment Since the First Touch | iBB | Scoop.it

Candida glabrata’s ability to cause human infections is tightly linked to its impressive ability to form persistent biofilms. The molecular control of this process is far from being clarified, as it lacks many of the typical features displayed by other Candida species. In this study, a combination of genetic screening, RNA-seq based transcriptomics, and Single-Cell Force Spectroscopy (SCFS), enabled the observation that the transcription factor CgEfg1, but not CgTec1, is necessary for the initial interaction of C. glabrata cells with both abiotic surfaces used in medical devices and epithelial cells, while both transcription factors orchestrate biofilm maturation. The knowledge gathered through this study by former PhD student Mafalda Cavalheiro, and an international team led by Miguel Cacho Teixeira, BSRG-iBB, including Etienne Dague, LAAS-CNRS, Geraldine Butler, University College Dublin, and Arsénio Fialho, BSRG-iBB, and just published in Communications Biology, is expected to contribute to guide the design of more successful therapeutic approaches.

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Development of Anti-Fouling Materials that Reduce Microbial Pathogen Adhesion

Development of Anti-Fouling Materials that Reduce Microbial Pathogen Adhesion | iBB | Scoop.it

The attachment of bacteria and other microbes to natural and artificial surfaces leads to the development of biofilms, which can further cause nosocomial infections. Thus, an important field of research is the development of new materials capable of preventing the initial adhesion of pathogenic microorganisms. In this work, novel polymer/particle composite materials were developed and characterized with respect to their mechanical, chemical and surface properties. Both S. aureus and C. glabrata exhibit a reduced capacity to adhere to the newly developed nanomaterials used in this study, thus showing their potential for bio-medical applications. This study, led by researchers from LAAS-CNRS, Toulouse, and co-authored by Mafalda Cavalheiro and Miguel Cacho Teixeira from BSRG-iBB, was just published in Nanomaterials.

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Mafalda Cavalheiro Receives Best Poster Award at MicroBiotec17

Mafalda Cavalheiro Receives Best Poster Award at MicroBiotec17 | iBB | Scoop.it
Mafalda Cavalheiro, PhD student from the PhD program in Biotechnology and Biosciences, has won one of the best poster prizes at the Congress of Microbiology and Biotechnology – Microbiotec17, held on December 7-9, in Porto, Portugal, with a communication entitled “Determining virulence by protecting the cell from host induced stresses: the unexpected role of C. glabrata multidrug transportes”. The work stems from a collaboration between researchers from BSRG/iBB (Rui Santos, Daniela Romão, Dalila Mil-Homens, Pedro Pais, Catarina Costa, Romeu Viana, Susana Santos and Arsénio M Fialho), under the supervision of Miguel Cacho Teixeira.
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BIOTECnico PhD Alumni Seminar: Mafalda Cavalheiro

BIOTECnico PhD Alumni Seminar: Mafalda Cavalheiro | iBB | Scoop.it

Mafalda Cavalheiro will be giving a talk entitled "Deciphering Mechanisms of Pathogenesis in Candida glabrata: in the Crossroad Between Drug Resistance and Virulence ", Tuesday the 16th of March at 16:00 h via zoom. Mafalda obtained her PhD in Biotechnology and Biosciences in 2020 and is currently working at A4F – Algae for Future, as a Junior R&D Project Manager.

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Following the Evolution Towards Fluconazole Resistance in C. glabrata

Following the Evolution Towards Fluconazole Resistance in C. glabrata | iBB | Scoop.it

The effectiveness of Candida glabrata as an emerging human pathogen relies on its ability to acquire azole drug resistance. In a paper just published in Antimicrobial Agents and Chemotherapy, the first time-course evaluation of the global gene expression changes that lead a drug susceptible C. glabrata clinical isolate to step-wise acquisition of resistance to azole drugs was conducted. This work, which results from the collaboration of six different teams under the coordination of Miguel C Teixeira from BSRG-iBB, highlights the multifactorial nature of azole resistance acquisition, including the Epa3 adhesin as a new player, while providing fascinating clues on the underlying evolutionary path. This knowledge is of crucial importance to design more effective antifungal therapy.

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