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Eduardo Brás Defends PhD Thesis in Biotechnology and Biosciences

Eduardo Brás Defends PhD Thesis in Biotechnology and Biosciences | iBB | Scoop.it

Eduardo Brás defended his PhD thesis in Biotechnology and Biosciences on Tuesday the 15th september 2020 (14:30 H). During the last years, and under the supervision João Pedro Conde from INESC-MN and Pedro Fernandes from BERG-iBB, Eduardo explored how microfluidic technology and microfabrication could be coupled with enzymes with goal of developing biosensing in different fields of application. The title of the thesis is “Biocatalysis in Microfluidic Systems: Biosensing and Rapid Screening Applications”.

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Portable Platform for Point-of-Need Testing of Plant Health

Portable Platform for Point-of-Need Testing of Plant Health | iBB | Scoop.it

Microfluidic biosensing devices are becoming a key part in the development of point-of-care diagnosis systems for medical, animal and agricultural applications alike. However, to fully take advantage of the features presented by microfluidics technology, one has to be capable of providing the appropriate instrumentation for the actuation of the devices and transduction of the results produced by said devices. A versatile and portable platform for the optical transduction of microfluidic devices was recently the target of a publication in the IEEE Sensors Journal  In this work, thin-film, hydrogenated amorphous silicon photosensors are used to transduce the optical assay for the detection of azelaic acid in wine producing grapes infected with the fungus B. cinerea. The portable prototype provides all necessary electronics for liquid manipulation, light sources and electronic amplification for the assay read-out. The work was performed by Biotechnology PhD student Eduardo Brás (INESC-MN/IBB) and Biotechnology Alumni Dr. Rui Pinto under the supervision ofJoão Pedro Conde (INESC-MN/DBE) and Pedro Fernandes (BERG-iBB).

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Point-of-need Pathogen Detection in Grapes

Point-of-need Pathogen Detection in Grapes | iBB | Scoop.it

Pathogenic infections in plant systems are on the rise, making their early detection in the field an important asset in order to avoid propagation amongst the rest of the crops. One biomarker of interest for this detection is Azelaic Acid (AzA). Based on this, a microfluidic device capable of detecting low concentrations of the acid was developed by Eduardo Brás under the supervision of Prof. João Pedro Conde (INESC-MN) and Prof. Pedro Fernandes (iBB), with the collaboration of Prof. Ana Margarida Fortes (FCUL). The results obtained using real samples as well as a description of the system, which exploits the inhibitory effect of AzA on the activity of the enzyme tyrosinase was published in the journal Analyst.

 

Photo details: Samir Budimčić - Own work, CC BY-SA 2.5, Wikimedia.

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Eduardo Brás Presents Research on Point-of-care Devices for Plant Health at Eurosensors 2018

Eduardo Brás Presents Research on Point-of-care Devices for Plant Health at Eurosensors 2018 | iBB | Scoop.it

Eduardo Brás from BERG-iBB delivered an oral presentation at the 32nd edition of Eurosensors in Graz, Austria, concerning his work on the development of a Point-of-Care device for early plant health assessment. The system developed consists of a microfluidic chip containing sample preparation and detection modules, coupled with integrated photodetectors for real time optical transduction. The work is part of Eduardo´s PhD project on Biotechnology, which is supervised by João Pedro Conde from INESC-MN and Pedro Fernandes from BERG-iBB in collaboration with Margarida Fortes from (BioISI). 

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Microfluidic Packed-Bed Reactors

Microfluidic Packed-Bed Reactors | iBB | Scoop.it

Optimization of biocatalytic processes is crucial to drive down the price of pharmaceutical and other high-value molecules. L-DOPA and dopamine are two molecules with pharmaceutical relevance, often used in the treatment of neurological diseases such as Parkinson’s disease. In a paper published in the Journal of Biotechnology, Biotechnology PhD student Eduardo Brás and supervisors João Pedro Conde (INESC-MN/DBE) and Pedro Fernandes (IBB) used a microfluidic packed-bed reactor to optimize the enzymatic conversion of L-tyrosine to dopamine. The work culminated with the up-scale (780-fold) of the optimal conditions for L-DOPA synthesis, while maintaining the same output as obtained in the miniaturized system. This type of system can be used to expedite process development in the future.

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Eduardo Brás Presents Multiplexed Detection with Microfluidics at MicroTAS 2019

Eduardo Brás Presents Multiplexed Detection with Microfluidics at MicroTAS 2019 | iBB | Scoop.it

Biotechnology PhD student, Eduardo Brás, gave a poster presentation at the 23rd edition of the MicroTAS conference in Basel, Switzerland. The poster was about the multiplexed detection of plant health biomarkers in grapes, using a microfluidic platform. The system developed consists of a microfluidic chip containing sample preparation and detection modules for both Azelaic Acid and Salicylic Acid, coupled with a-Si:H for real time optical transduction. The work was carried out under the supervision of Prof. João Pedro Conde (INESC-MN) and Prof. Pedro Fernandes (iBB-BERG), with the collaboration of Prof. Ana Margarida Fortes (FCUL). Eduardo was also co-author of another poster presentation concerning the development of a microfluidic chip for targeted phage selection for personalized colorectal cancer treatment and received a travel grant to the conference.

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Eduardo Brás Delivers Poster Presentation at the 2019 Transducers-Eurosensors Joint Conference

Eduardo Brás Delivers Poster Presentation at the 2019 Transducers-Eurosensors Joint Conference | iBB | Scoop.it

Eduardo Brás delivered a poster presentation entitled "A Portable Microfluidic System for the Detection of Health Biomarkers in Grapes at the Point of Need", at the 2019 Transducers-Eurosensors joint conference, in Berlin, Germany. He demonstrated his work concerning the development of a portable device capable of fungal infection detection in grape trees through the detection of plant metabolites, through the use of a enzymatic reaction in a microfluidic device. This work was supervised by Prof. João Pedro Conde (INESC-MN) and Prof. Pedro Fernandes (IBB) and counted with the collaboration of Prof. Ana Margarida Fortes (FCUL).

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