iBB

BSRG researchers have unveiled new targets for the anti-cancer protein azurin using a breast cancer model. In a paper published jointly with colleagues from IPATIMUP in The International Journal of Biochemistry and Cell Biology, the team led by Arsénio Fialho describes the use of DNA microarrays to understand the effects of azurin in invasive breast cancer cells overexpressing P-cadherin. The gene transcription data gathered shows that apoptosis is induced and endocytosis is up-regulated to mediate the controlled process of azurin entry in cells. A number of genes coding for membrane receptors frequently overexpressed in breast cancer are down-regulated, suggesting that these new targets could be exploited in the future. Click on title to learn more.