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Institute for Bioengineering and Biosciences
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António Soure Defends PhD Thesis in Bioengineering

António Soure Defends PhD Thesis in Bioengineering | iBB | Scoop.it
António Soure will be defending his Ph D thesis in Bioengineering (MIT Portugal program) at Instituto Superior Técnico, friday the 17th march 2017 (11:00 H, room PA3). During the last years, and under the supervision of Joaquim Cabral and Cláudia Lobato Silva from SCERG-IBB, António focused his efforts on the study of the manufacturing of MSC for cell therapy applications. The title of António's thesis is “Scalable Manufacturing of Mesenchymal Stem/Stromal Cells for Cell Therapies and the Role of the Notch Signaling Pathway in the Human Hematopoietic Systems”.
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Human Platelet Lysate-based Isolation and Scalable Manufacturing of Umbilical Cord Matrix-Derived Mesenchymal Stem/Stromal Cells

Human Platelet Lysate-based Isolation and Scalable Manufacturing of Umbilical Cord Matrix-Derived Mesenchymal Stem/Stromal Cells | iBB | Scoop.it

Umbilical cord matrix (UCM)-derived mesenchymal stem/stromal cells (MSC) are promising therapeutic candidates for Regenerative Medicine settings. However, given the high cell doses required for clinical applications, the large-scale manufacturing of UCM MSC complying with good manufacturing practices is mandatory. In a study published in the Journal of Tissue Engineering and Regenerative Medicine, a group of researchers from BERG-iBB reported the establishment of an integrated culture platform based on a human platelet lysate supplement for the effective isolation and expansion of UCM MSC, using a xenogeneic-free microcarrier-based system featuring easy scalability. This represents an important advance in obtaining safer and clinically meaningful MSC numbers for clinical translation. Click on title to learn more.

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