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Scooped by
Ed Rybicki
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A vaccine made of an adenovirus prime and a modified-pox-virus boost was best at stopping infection. Three-quarters of the monkeys that received no vaccine developed SIV after one exposure, whereas only 12% of the animals that got the best vaccine did so. Prime-boost studies and a good infection model...nice virology and vaccinology. And a possible route to a human HIV vaccine
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Ed Rybicki
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"The norovirus has affected about 85 students this week, according to the GW University Student Health Service. Although experts are still unsure of where the virus originated, most of the cases have been found at the Foggy Bottom campus." To be renamed the Soggy Bottom campus?? Sorry, couldn't resist...B-)
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Ed Rybicki
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I'm assuming this is in Vietnam, seeing as details are a little sketchy, but this could be getting serious.
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Ed Rybicki
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A major milestone in the history of HIV is underway and may forever change the face of the disease. Interesting...suddenly AIDS becomes just another African chronic disease. Because of course, everyone has access to ARVs. Yeah, right.
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Scooped by
Ed Rybicki
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Here, we report the expression of the fusion (F) gene of the Newcastle disease virus (NDV) in transgenic maize plants. The expression of the transgene, driven by the maize ubiquitin promoter, caused accumulation of the F protein in maize kernels. The presence of the transgene was verified by Southern and western blots. Feeding chickens with kernels containing the F protein induced the production of antibodies, which conferred protection against a viral challenge. This protection was comparable to that conferred by a commercial vaccine. Possible uses of this plant-based F protein as a potential mucosal vaccine are discussed. Going green: some day, all vaccines that matter will be made this way...B-)
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Ed Rybicki
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Some 90 percent of people are exposed to the Epstein Barr virus (EBV) at some point in their life. Even though it is quickly cleared from the body, the virus can linger silently for years in small numbers of infected B cells.
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Scooped by
Ed Rybicki
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(Adds source close to U.S.biosecurity board, WHO quotes)By Stephanie Nebehay and Kate KellandGENEVA/LONDON, Feb 17 (Reuters) - Two studies showinghow scientists mutated the H5N1 bird flu virus into... My take on this: "Asked about the potential bioterrorism risks of his and the U.S. team's work, Fouchier said "it was the view of the entire group" at the meeting that the risks that this particular virus or flu viruses in general could be used as bioterrorism agents "would be very, very slim". "The risks are not nil, but they are very, very small," he said."
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Scooped by
Ed Rybicki
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'Gonorrhea, one of the most common sexually transmitted diseases in the United States, is increasingly showing resistance to one of the last known effective antibiotic treatments, leading researchers from the Centers for Disease Control to 'sound the alarm" about potentially untreatable forms of the disease.' OK, so it's not a virus, but everyone should be scared of this: coming soon to a sexually promiscuous person near you....
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Ed Rybicki
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Experts have delayed a decision about whether controversial research into the H5N1 bird flu virus should be published. And do it grinds on...meanwhile, so does the virus
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Ed Rybicki
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The nervous system has evolved rather complicated barriers that facilitate access to nutrients and contact with the outside world, but block entry of pathogens and toxins [1]. However, when these barriers are reduced for any number of reasons, nervous system infections are possible. When they occur, they can be devastating and, even with good antiviral drugs, difficult to manage. EXCELLENT review of a very interesting topic. Edited by Vincent Racaniello, who obviously has more than one job B-)
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Ed Rybicki
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"Opinion: What Is Life?|...What should the definition contain, to be suitable for all varieties of observable life? Humans, animals, plants, microorganisms. Do viruses also belong to life?" I used to boggle students' minds with this one. Or thought I did - maybe they didn't care?? However, one Honours student (who must have been smart; he dropped out and is now a rabbi) gave me this beautiful definition: "Life is a series of eddies in the entropic flow - and viruses are smaller eddies within those swirls".
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Ed Rybicki
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WASHINGTON -- What can you do to help stop a ravaging virus from spreading farther in Maryland's turtle population? Told you we'd do "other things". I quite like turtles.
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Ed Rybicki
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Who DID show that influenza was a virus?
The history books will tell you that it was only in 1933 that Influenza A virus was shown to BE a virus - yet there appears to me to be very clear evidence that French scientists working in 1918 actually made the first call. From "Quelques notions experimentales sur le virus de la grippe", by MM Charles Nicolle and Charles Lebailly in Annales de l'Institut Pasteur of 1918: Conclusions 1⁰ The bronchial expectoration of people suffering from influenza, collected during the acute period, is virulent. 2⁰ The monkey (M. cynomolgus) is sensitive to the virus by sub-conjunctival and nasal inoculation. 3⁰ The influenza agent is a filterable organism. The inoculation of the filtrate has indeed reproduced the illness in two of the people injected subcutaneously; on the other hand when given intravenously it appears to be ineffective (two failures out of two tries). 4⁰ It is possible that the flu virus does not occur in the patient’s blood. The blood of a monkey with flu, inoculated subcutaneously, did not infect man; the negative blood result of subject 2 at D, is however, not convincing, the blood route seeming to be ineffective for the flu virus transmission. (Translated by Mrs Francoise Williamson) It convinced me. But, as my medical colleagues will be quick to tell you, I'm an amateur in this area. Albeit an enthusiastic one...B-) Picture courtesy of Russell Kightley Media
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Ed Rybicki
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OSLO, NORWAY--(Marketwire -02/15/12)- Bionor Pharma (Oslo: BIONOR.OL - News) News Summary Final review of phase IIb data confirms statistically significant 64% reduction of viral load set point (average of the last two viral load measurements... And here come more therapeutic vaccine interventions for AIDS patients: the gates are opening....
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Ed Rybicki
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TEHRAN, Iran (AP) — A senior Iranian intelligence official says an estimated 16000 computers were infected by the Stuxnet virus. The powerful virus targeted Iran's nuclear facilities and other industrial sites in 2010, and ... ViroBlogy readers will know I think computer viruses are quite legitimate life forms - and should we be more worried about this, which is a genuinely engineered infectious agent, than H5N1?
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Ed Rybicki
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Egypt - Report of H9 influenza in poultry in 9 provinces - more than 50% mortality rate Egypt... Interesting - as much for the machine translation as for anything else, which renders the content pretty much inscrutable. But bottom line: H9N2 in Egypt and causing a problem in poultry. Like the Twitter revolution, this may spread and spread....
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Ed Rybicki
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Interesting account of the papers that are ATTEMPTING to describe how researchers made H5N1 viruses that were aerosol transmitted in ferrets
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Ed Rybicki
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Science and Nature have papers that describe a version of the avian flu that spreads among mammals. The World Health Organization has now weighed in with its thoughts on whether they should be published. One comment: "The publication of the full details of the paper would allow anyone with a reasonable level of molecular biology skill to order up the requisite DNA and produce a copy of the newly evolved virus. That raises the risk that the virus could be spread by a lab that doesn't have the requisite containment expertise, or by someone who intentionally uses it as a weapon." Utter bullshit! The lab would have to ALSO have the skills in reverse genetics to be able to engineer ss(-)RNA segment expession in a context that would allow reassortment with a live flu virus, in order to make something at all!!
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Ed Rybicki
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News, video, background information and discussion on the spread of the Schmallenberg virus in the UK... Sometimes you need to get news about viruses that is relevant to people whose living is affected...farmers, in this case
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Ed Rybicki
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HANOI, Vietnam — Thought bird flu was gone? Recent human deaths in Asia and Egypt are a reminder that the H5N1 virus is still alive and dangerous, and Vietnam is grappling with a new strain that has outsmarted vaccines used to protect poultry flocks. And they sit in Geneva and argue....
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Ed Rybicki
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WebMD shows you cold symptoms and signs of flu virus. Learn what fever, cough, runny nose, and sore throat may mean, and treatment and prevention options. I have a morbid fascination with this just now, having had sinusitis, rhinitis, headache AND fever. Damn viruses....
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Ed Rybicki
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...we find that Ded1p and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is another host factor for TBSV, play non-overlapping functions to enhance (+)-strand synthesis. ... two small RNA viruses, which do not code for their own helicases, seems to recruit a host RNA helicase to aid their replication in infected cells. Both ss(-)RNA and ss(+)RNA viruses need to bias their replication machinery towards over-production of the genomic strand - and this paper goes a long way to explaining how that happens for two unrelated ss(+)RNA viruses infecting very different hosts.
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Scooped by
Ed Rybicki
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Propitious Prions |...The poor cousins of viruses come out of the shadows - and turn out to be actually useful! For yeasts, anyway. Epigenetics and Lamarckian evolution becoming respectable at last?
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Ed Rybicki
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A knowledge resource to understand virus diversity...Ranavirus, in this case. A good general resource: ViralZone Current statistics January, 2012 426 Virus description pages: 83 Families 334 Genera 9 individual Species Linking to: 364 reference strains 16,010 manually reviewed proteins1, 290,680 unreviewed viral proteins
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Scooped by
Ed Rybicki
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Maize streak virus -strain A (MSV-A; Genus Mastrevirus, Family Geminiviridae), the maize-adapted strain of MSV that causes maize streak disease throughout sub-Saharan Africa, probably arose between 100 and 200 years ago via homologous recombination... Sometimes you have to be proud of your academic children...B-) Picture courtesy Russell Kightley Media
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