Vectorology - GEG Tech top picks

The scientists used lentiviral vectors to deliver CRISPR/Cas9 to disrupt the gene for the class II transactivator (CIITA). They observed that the loss-of-function arises from bi-allelic gene disruption in CIITA that leaves other essential properties of the cells intact, including self-assembly into blood vessels in vivo, and that the altered phenotype can be rescued by re-introduction of CIITA expression.

www.geg-tech.com/Vectors