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Vectorology - GEG Tech top picks
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The authors tested a Doxycycline (Dox)-inducible “all-in-one” lentiviral vector (Lv.TII vectors) design which expresses a reverse transactivator protein (rtTA2S-M2) in human hematopoietic cells. Functionality of Dox-inducible hCDD expression was demonstrated by a more than 10-fold increase in cytosine arabinoside (Ara-C) resistance of Lv.TII.CDD transduced K562 cells. In addition, Lv.TII.CDD transduced CD34+ derived myeloid cells were protected from up to 300 nM Ara-C.
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