This study investigated the role of KLF4 in angiogenesis and underlying molecular mechanisms in human retinal microvascular endothelial cells (HRMECs). In this way, the authors used lentiviral vectors which mediated inducible expression and shRNA knockdown of KLF4. The demonstrated that KLF4 promotes angiogenesis by transcriptionally activating VEGF expression, thus activating the VEGF signaling pathway in HRMECs.
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This study investigated the role of KLF4 in angiogenesis and underlying molecular mechanisms in human retinal microvascular endothelial cells (HRMECs). In this way, the authors used lentiviral vectors which mediated inducible expression and shRNA knockdown of KLF4. The demonstrated that KLF4 promotes angiogenesis by transcriptionally activating VEGF expression, thus activating the VEGF signaling pathway in HRMECs.
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