Vectorology - GEG Tech top picks

Pulmonary arterial hypertension (PAH) is a life-threatening disorder that ultimately causes heart failure. In this study, the authors used a shRNA lentiviral vector which targets Bcl2 and another which expresses  hypoxia response element (HRE) to understand  the causes of PAH. Their results suggest that HRE-mediated Bcl-2 inhibition can effectively attenuate hypoxia-induced apoptosis resistance in pulmonary microvascular endothelial cells by downregulating Bcl-2 expression and upregulating caspase-3 and P53 expression. This study therefore reveals critical insight into potential therapeutic targets for treating PAH.

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