Vectorology - GEG Tech top picks

The authors transduced CD4+ cells with a lentiviral vector which expresses Foxp3. They observed that full length and N-cleaved Foxp3 transduced CD4+ T cells similarly suppressed the in vitro proliferation of Teffs. However, the C- or N&C-cleaved Foxp3 forms afforded almost no suppressive function, indicating a crucial role of the human Foxp3 C-terminal region in Tregs suppressive activity, in marked contrast with the report of superior suppressive activity for the C-cleaved murine Foxp3 compared to the full length.

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