Vectorology - GEG Tech top picks

Alpha-fetoprotein (AFP) is overexpressed in hepatocellular carcinoma (HCC) and could be a potential target for adoptive immunotherapy. In this study, the authors modify T cells thanks to a lentiviral vector which expresses TCR α/β chain genes of AFP.

They observe that the number of IFN-γ secretion T cells and the specific cytotoxicity in tumor-bearing NOD/SCID mice are significantly raised in transgenic CTLs. TCR gene transfer seems to be a promising strategy for the treatment of HCC.

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