Understanding how the two different kinds of muscle memory work can help you get off to a strong start if you’re establishing a fitness routine or rebooting one.
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Physical and Mental Health - Exercise, Fitness and Activity
Healthy body, healthy mind! Physical Exercise, Fitness, Running, Jogging, Gym and Activity. Twitter Hashtag: #GymEd Curated by Peter Mellow |
Scooped by Peter Mellow |
Understanding how the two different kinds of muscle memory work can help you get off to a strong start if you’re establishing a fitness routine or rebooting one.
Scooped by Peter Mellow |
It turns out that muscle memory is not just in the mind. It's in the muscle fibers, too.
Scooped by Peter Mellow |
Muscles develop a lasting molecular “memory” of past resistance exercises that helps them bounce back from long periods of inactivity.
Scooped by Peter Mellow |
It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 CpGs) and gene expression analysis after muscle hypertrophy (loading), return of muscle mass to baseline (unloading), followed by later hypertrophy (reloading). We discovered increased frequency of hypomethylation across the genome after reloading (18,816 CpGs) versus earlier loading (9,153 CpG sites). We also identified AXIN1, GRIK2, CAMK4, TRAF1 as hypomethylated genes with enhanced expression after loading that maintained their hypomethylated status even during unloading where muscle mass returned to control levels, indicating a memory of these genes methylation signatures following earlier hypertrophy. Further, UBR5, RPL35a, HEG1, PLA2G16, SETD3 displayed hypomethylation and enhanced gene expression following loading, and demonstrated the largest increases in hypomethylation, gene expression and muscle mass after later reloading, indicating an epigenetic memory in these genes. Finally, genes; GRIK2, TRAF1, BICC1, STAG1 were epigenetically sensitive to acute exercise demonstrating hypomethylation after a single bout of resistance exercise that was maintained 22 weeks later with the largest increase in gene expression and muscle mass after reloading. Overall, we identify an important epigenetic role for a number of largely unstudied genes in muscle hypertrophy/memory.
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Muscles may “remember” in ways that will allow us to regain fitness once gyms reopen and we start working out again.
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New research hands down verdicts on what to lift, how much, and how hard
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Shifting, quicksilver workouts may yield mental benefits that more rote regimens do not.
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It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 CpGs) and gene expression analysis after muscle hypertrophy (loading), return of muscle mass to baseline (unloading), followed by later hypertrophy (reloading). We discovered increased frequency of hypomethylation across the genome after reloading (18,816 CpGs) versus earlier loading (9,153 CpG sites). We also identified AXIN1, GRIK2, CAMK4, TRAF1 as hypomethylated genes with enhanced expression after loading that maintained their hypomethylated status even during unloading where muscle mass returned to control levels, indicating a memory of these genes methylation signatures following earlier hypertrophy. Further, UBR5, RPL35a, HEG1, PLA2G16, SETD3 displayed hypomethylation and enhanced gene expression following loading, and demonstrated the largest increases in hypomethylation, gene expression and muscle mass after later reloading, indicating an epigenetic memory in these genes. Finally, genes; GRIK2, TRAF1, BICC1, STAG1 were epigenetically sensitive to acute exercise demonstrating hypomethylation after a single bout of resistance exercise that was maintained 22 weeks later with the largest increase in gene expression and muscle mass after reloading. Overall, we identify an important epigenetic role for a number of largely unstudied genes in muscle hypertrophy/memory.
Scooped by Peter Mellow |
Whether its playing Chopsticks on the piano, riding a bike or repeatedly mistyping the same few letters, chances are you've experienced muscle memory. But there's considerable disagreement about where that 'memory' is stored.