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‘Junk DNA’ plays active role in cancer progression, researchers find | KurzweilAI

Scientists at The University of Nottingham have found that a genetic rogue element produced by sequences until recently considered “junk DNA” could promote cancer progression.

 

The researchers, led by Dr Cristina Tufarelli, in the School of Graduate Entry Medicine and Health Sciences, discovered that the presence of this faulty genetic element — known as chimeric transcript LCT13 — is associated with the switching off of a known tumor suppressor gene (known as TFPI-2) whose expression is required to prevent cancer invasion and metastasis. Their findings suggest that LCT13 may be involved in switching off TFPI-2.

 

 

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Bladderwort Study Adds To The Debate On “Junk” DNA

Bladderwort Study Adds To The Debate On “Junk” DNA | Longevity science | Scoop.it

Only about two percent of the human genome contains genes. The other 98 percent has been likened to cosmology’s dark matter that fills the space between stars – there’s a lot of it, but nobody really knows what it does. Over the years scientists have put faith into the logic of evolution: if it’s there, it must serve a purpose. But a recent study shows that not all genomes are created equally. Unlike human genomes, the carnivorous bladderwort’s genome makes the most of its allotted bases having only an estimated 2 percent of non-coding DNA, or so-called “junk” DNA.

 

The genome of the carnivorous bladderwort plant (Utricularia gibba) is minuscule compared to the human genome – 82,000 bases versus our near 3 billion. But while it’s small, the genome is extremely efficient. About 97 percent of its genome codes for an estimated 28,500 genes and the short sequences that control those genes. The authors of a study mapping the bladderwort genome surmise that, through many generations, the non-coding portion of the carnivorous bladderwort’s genome has been systematically removed, resulting in just 3 percent of non-coding DNA.

 

 

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