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What causes a cell to metastasize into a cancerous tumor?
To find out, Corey Neu, an assistant professor in Purdue University‘s Weldon School of Biomedical Engineering, and colleagues have combined an atomic force microscope (AFM) and a nuclear magnetic resonance system.
An AFM uses a tiny vibrating probe called a cantilever with a tip that travels over the surface of a cell to yield information about materials and surfaces at the scale of nanometers, or billionths of a meter.
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Electron microscopes can produce incredibly detailed and even 3D views of sub-cellular structures, but often at the cost of losing the bigger picture. Researchers at Leiden University in the Netherlands, however, have leveraged a technique called virtual nanoscopy that enables researchers to observe the whole of a cell and its intricate details in a single image.
With the method, the team stitches together nanometer resolution photographs of what's gone under the scope to create a map with adjustable zoom a la Google Maps. Their study created a 281-gigapixel image (packed with 16 million pixels per inch) of a 1.5-millimeter-long zebrafish embryo. Via Anne Osterrieder, Dr. Stefan Gruenwald
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