AppJS - SDK on top of nodejs to build desktop apps using HTML5/CSS/JS | JavaScript for Line of Business Applications | Scoop.it
From appjs.com - September 26, 2013 5:23 PM

AppJS is an SDK to develop desktop applications using Node.js melded with Chromium. With AppJS you can develop desktop tools and applications using the same libraries and knowledge used to build websites.

Using AppJS you don't need to be worry about coding cross-platform or learning new languages and tools. You are already familiar with HTML, CSS and Javascript. What is better than this stack for application development? Beside, AppJS uses Chromium at the core so you get latest HTML 5 APIs working. So relax and focus on the task your application should do.