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Scoop.it!
INNATE IMMUNITY The inside story on complement activation
Alfredo Corell's insight:
The evolutionarily ancient complement system might have started life as an intracellular activation pathway rather than as a liver-derived serum effector cascade.
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Nature Reviews Immunology 14, 141 (2014).
Alfredo Corell's insight:
The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host–microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host–commensal microbial relationships and immune cell homeostasis in the intestine. Free download with registration: http://www.nature.com/nri/journal/v14/n3/pdf/nri3608.pdf
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This month's featured article is on the intestinal microbiota: http://t.co/giUTDnF2sU
Alfredo Corell's insight:
Review
Nature Reviews Immunology 13, 321-335 (May 2013) | doi:10.1038/nri3430 Role of the gut microbiota in immunity and inflammatory diseaseNobuhiko Kamada1, Sang-Uk Seo1, Grace Y. Chen2 & Gabriel Núñez
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ABSTRACT: The mononuclear phagocyte system (MPS) has historically been categorized into monocytes, dendritic cells and macrophages on the basis of functional and phenotypical characteristics. However, considering that these characteristics are often overlapping, the distinction between and classification of these cell types has been challenging. In this Opinion article, we propose a unified nomenclature for the MPS. We suggest that these cells can be classified primarily by their ontogeny and secondarily by their location, function and phenotype. We believe that this system permits a more robust classification during both steady-state and inflammatory conditions, with the benefit of spanning different tissues and across species.