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Over the past decade, scientists have made incredible strides in the field of HIV research, but a cure for the human immunodeficiency virus has still eluded scientists.
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These findings mean that scientists have many more proviruses to kill in order to fully cure an individual of HIV. However, Siliciano hopes his research will dissuade patients from entering into clinical trials testing a “shock and kill” approach to curing the virus, which involves activating many of the body’s T cells to force the proviruses to activate. Since the size of the provirus reservoir is so large, Siliciano said this technique could lead to major damage in the body.
The paper in "Cell": http://www.cell.com/abstract/S0092-8674(13)01157-4 ;