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Rheumatoid arthritis (RA) is an autoimmune disorder in which immune cells attack the joints, causing inflammation, swelling, and erosion. Specific sets of immune cells, known as T cells, are responsible for inducing disease. In this issue of the Journal of Clinical Investigation, researchers led by Harvey Cantor at Harvard University analyzed the contributions of different subsets of T cells to an RA-like condition in mice.
A summary in the news:
http://www.news-medical.net/news/20130211/CD82b-Tregs-can-remove-pathogenic-T-cell-subsets-and-inhibit-progression-of-RA.aspx
The complete article:
J Clin Invest. doi:10.1172/JCI66938.Copyright © 2013, The American Society for Clinical Investigation.Research ArticleAmelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells
Jianmei W. Leavenworth1,2, Xiaolei Tang1,2, Hye-Jung Kim1,2, Xiaoyang Wang1,2,3,4 and Harvey Cantor1,2