Trends in Immunology, 11 December 2013
Copyright © 2013 Elsevier Ltd All rights reserved.
10.1016/j.it.2013.11.003
AuthorsYusuke Endo,Kiyoshi Hirahara,Ryoji Yagi,Damon J. Tumes,Toshinori Nakayama
Get Started for FREE
Sign up with Facebook Sign up with X
I don't have a Facebook or a X account
Your new post is loading...
Your new post is loading...
|
Immunological memory is a hallmark of adaptive immunity. Memory CD4 T helper (Th) cells are central to acquired immunity, and vaccines for infectious diseases are developed based on this concept. However, memory Th cells also play a critical role in the pathogenesis of various chronic inflammatory diseases, including asthma. We refer to these populations as ‘pathogenic memory Th cells.’ Here, we review recent developments highlighting the functions and characteristics of several pathogenic memory type Th2 cell subsets in allergic inflammation. Also discussed are the similarities and differences between pathogenic memory Th2 cells and recently identified type 2 innate lymphoid cells (ILC2), focusing on cytokine production and phenotypic profiles.