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La Sociedad Española de Alergología e Inmunología Clínica (SEAIC) ha defendido este jueves el empleo del diagnóstico molecular como complemento a las pruebas... 
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Each food fish can cause specific allergies
Alfredo Corell's insight:
Go to the journal article:
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The Journal of Allergy and Clinical Immunology, Volume 132, Issue 4, Pages 777-787, October 2013, Authors:Donald W. MacGlashan, MD, PhD
Alfredo Corell's insight:
Both the treatment of patients with allergic diseases and the study of allergic disease mechanisms depend on a wide variety of assays that in various ways assess the presence and function of IgE antibody. The study of allergic diseases could benefit from the study of its 2 principle cellular participants, mast cells and basophils, but the basophil is more accessible than mast cells for ex vivo studies. Its functionality is tested by using 2 predominant methodologies: the secretion of mediators of allergic inflammation and the expression of proteins on the plasma membrane after stimulation. Each approach has benefits. There are also many operational details to consider regardless of which general approach is taken, and proper interpretation of the methods requires a good understanding of the reagents used and the receptors expressed on basophils and a detailed understanding of the factors regulating aggregation of cell-surface IgE.
Gilbert C FAURE's curator insight,
October 3, 2013 10:17 AM
of course, we lost cytologist's competencies... to look at cells. We have to rely on secretions assays or cytometric analysis which work pretty well in our experience. Unfortunately, clinical data to correlate biological are not easy to collect and the topic is not very fashionable, somehow outdated. But, if JACI is devoting a review on the topic, the tests might come back on stage?
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ALLERGY Review Article You have free access to this contentSchnitzler's syndrome: diagnosis, treatment, and follow-upA. Simon1,B. Asli2,M. Braun-Falco3,H. De Koning4,J.-P. Fermand2,C. Grattan5,K. Krause6,H. Lachmann7,C. Lenormand8,V. Martinez-Taboada9,M. Maurer6,M. Peters10,R. Rizzi11,F. Rongioletti12,T. Ruzicka3,L. Schnitzler13,B. Schubert14,J. Sibilia15,D. Lipsker8 Article first published online: 9 MAR 2013 DOI: 10.1111/all.12129
Alfredo Corell's curator insight,
April 3, 2013 3:00 AM
Schnitzler's syndrome is characterized by recurrent urticarial rash and monoclonal gammopathy, associated with clinical and biological signs of inflammation and a long-term risk of AA amyloidosis and overt lymphoproliferation.
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The lack of access to validated penicillin testing reagents has been a major problem for nearly a decade. The minor antigenic determinants appear to be important for diagnosing penicillin allergy.
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El laboratorio de Inmunología (inmunoLAB) del Instituto Universitario de Oftalmobiología Aplicada (lOBA) de la Universidad de Valladolid ofrece sus servicios a todos los profesionales de las Ciencias de la Visión que deseen una asistencia especializada en todos aquellos procesos o patologías oculares de carácter inmune o infeccioso.
Laboratorio de Inmunología (inmunoLAB)
Alfredo Corell's curator insight,
December 17, 2012 5:51 PM
Feel free of asking any question or make any suggestion.
Alfredo Corell's curator insight,
September 8, 2013 11:34 AM
Any sample (biopsies, brush or impresion cytologies, corneal scraping, vitreous or aqueus humour, ....) DIAGNOSTIC TESTS FOR: |
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The diagnosis of food allergy: a systematic review and meta-analysis. Full text. http://t.co/PrRzTekHct
Alfredo Corell's insight:
The diagnosis of food allergy: a systematic review and meta-analysis K. Soares-Weiser1, Y. Takwoingi2, S. S. Panesar3, A. Muraro4, T. Werfel5, K. Hoffmann-Sommergruber6, G. Roberts7,8,9, S. Halken10, L. Poulsen11, R. van Ree12,13, B. J. Vlieg-Boerstra14, A. Sheikh3,15,*, on behalf of the EAACI Food Allergy and Anaphylaxis Guidelines Group†
Conclusions The evidence base is limited and weak and is therefore difficult to interpret. Overall, SPT and sIgE appear sensitive although not specific for diagnosing IgE-mediated food allergy.
Gilbert C FAURE's curator insight,
December 15, 2013 11:16 AM
Metaanalysis of heterogeneous biomarkers and more heterogeneous clinical situations is not the best way to synthetise a complex medical syndrome
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Armentia: «Tenemos un gran equipo, que hace diagnóstico y tratamiento de alto nivel»
Alfredo Corell's insight:
Ver página de la Sociedad Castellano-Leonesa de Alergia e Inmunología Clínica, presidida por la Dra. Alicia Armentia
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Alfredo Corell's insight:
The literature on diagnostic tests for food allergy currently lacks clear consensus regarding the accuracy and safety of different investigative approaches. The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management, and impact on quality of life, which will be used to inform the formulation of clinical recommendations. The aim of this systematic review will be to assess the diagnostic accuracy of tests aimed at supporting the clinical diagnosis of IgE-mediated food allergy.
link to the provisional pdf: http://www.ctajournal.com/content/pdf/2045-7022-3-18.pdf
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Skin Prick Testing Skin prick testing measures specific IgE attached to cells in the skin. This is probably the most commonly used allergy test and is appropriate for both inhaled and ingested (eaten) allergies.
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Allergy tests — Overview covers definition, risks, results of skin tests for allergic sensitivities.
Explore the "basics", "in-depth", "multimedia" and "resources" for a complete explanation about Allergy skin tests
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La confianza en la coste-eficiencia de esta prueba de detección consistente en un análisis de sangre la razona el experto en un estudio realizado en la Comunidad de Madrid y publicado en la revista 'Allergy'. En él, ha confirmado que supone un ahorro del gasto y generar información "no solo a la ora de elegir una vacuna u otra, sino que predice un poco cual va a ser la evolución del paciente".
Por ello, sostiene que debe realizarse en "prácticamente todo tipo de pacientes", como los alérgicos a alimentos, pólenes, ácaros o epitelios de animales. A pesar de que existen casos de pacientes muy sencillos y que "se solventan con pruebas cutáneas", advierte de que "cada vez hay más pacientes que aparentemente son sensibles a muchas cosas, y que son los que se benefician".