Immunology and Biotherapies
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Page Ressources et Actualités du DIU immunologie et biothérapies
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Rescooped by Gilbert C FAURE from Cancer Immunotherapy Review and Collection
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Role of CD154 in cancer pathogenesis and immunotherapy - Cancer Treatment Reviews

Role of CD154 in cancer pathogenesis and immunotherapy - Cancer Treatment Reviews | Immunology and Biotherapies | Scoop.it
From www.cancertreatmentreviews.com - May 10, 2015 2:37 AM
Highlights

 

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CD154 is a co-stimulatory molecule known for its role in inflammatory and autoimmune diseases.

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CD154 and its receptor, CD40 are expressed in many types of tumors.

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The CD154/CD40 interaction is capable of inducing the proliferation and rescue from apoptosis of tumor cells.

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CD154 activates anti-tumoral immunity, and by engaging CD40 may induce apoptosis of tumor cells.

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The role of CD154 in cancer immunotherapy was demonstrated in animal models and clinically assessed in patients.


Via Krishan Maggon
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Krishan Maggon 's curator insight, May 10, 2015 2:00 AM

doi:10.1016/j.ctrv.2015.03.007

 

Cancer Treatment Reviews

Volume 41, Issue 5, May 2015, Pages 431–440

Laboratory-Clinic Interface Role of CD154 in cancer pathogenesis and immunotherapyGhada S. Hassan, John Stagg, Walid Mourad, 
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Rescooped by Gilbert C FAURE from Cancer Vaccines Collection
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A Novel Therapy for Melanoma Developed in Mice: Transformation of Melanoma into Dendritic Cells with Listeria monocytogenes

A Novel Therapy for Melanoma Developed in Mice: Transformation of Melanoma into Dendritic Cells with Listeria monocytogenes | Immunology and Biotherapies | Scoop.it
From journals.plos.org - March 14, 2015 7:42 AM
Listeria monocytogenes is a gram-positive bacteria and human pathogen widely used in cancer immunotherapy because of its capacity to induce a specific cytotoxic T cell response in tumours.

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Krishan Maggon 's curator insight, March 12, 2015 3:53 AM

These results support the use of low doses of pathogenic Listeri as safe melanoma therapeutic vaccines that do not require antibiotics for bacterial removal. 


Citation: Bronchalo-Vicente L, Rodriguez-Del Rio E, Freire J, Calderon-Gonzalez R, Frande-Cabanes E, et al. (2015) A Novel Therapy for Melanoma Developed in Mice: Transformation of Melanoma into Dendritic Cells with Listeria monocytogenes. PLoS ONE 10(3): e0117923. doi:10.1371/journal.pone.0117923
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Rescooped by Gilbert C FAURE from Cancer Immunotherapy Review and Collection
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Immune-mediated mechanisms influencing the efficacy of anticancer therapies: Trends in Immunology

Immune-mediated mechanisms influencing the efficacy of anticancer therapies: Trends in Immunology | Immunology and Biotherapies | Scoop.it
From www.cell.com - April 12, 2015 3:18 AM

Highlights

 

•Anticancer therapies alter the composition, phenotype, and function of immune cells.•The immune system is a major regulator of the success of anticancer therapy.•Immunotherapy and immunomodulatory agents often synergize with conventional therapies.•Resistance mechanisms following immunotherapy and immunodulatory agents are not fully defined.•Targeting both cancer cells and immune cells may be the key to fight metastasis.

 

Conventional anticancer therapies, such as chemotherapy, radiotherapy, and targeted therapy, are designed to kill cancer cells. However, the efficacy of anticancer therapies is not only determined by their direct effects on cancer cells but also by off-target effects within the host immune system. Cytotoxic treatment regimens elicit several changes in immune-related parameters including the composition, phenotype, and function of immune cells. Here we discuss the impact of innate and adaptive immune cells on the success of anticancer therapy. In this context we examine the opportunities to exploit host immune responses to boost tumor clearing, and highlight the challenges facing the treatment of advanced metastatic disease.


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Krishan Maggon 's curator insight, April 12, 2015 2:48 AM

Trends in Immunology

Volume 36, Issue 4, p198–216, April 2015Feature Review Immune-mediated mechanisms influencing the efficacy of anticancer therapiesSeth B. Coffelt, Karin E. de VisserDivision of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands DOI: http://dx.doi.org/10.1016/j.it.2015.02.006
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