Your new post is loading...
Highlights
Via Krishan Maggon
•
CD154 is a co-stimulatory molecule known for its role in inflammatory and autoimmune diseases.
•CD154 and its receptor, CD40 are expressed in many types of tumors.
•The CD154/CD40 interaction is capable of inducing the proliferation and rescue from apoptosis of tumor cells.
•CD154 activates anti-tumoral immunity, and by engaging CD40 may induce apoptosis of tumor cells.
•The role of CD154 in cancer immunotherapy was demonstrated in animal models and clinically assessed in patients.
Via Krishan Maggon
doi:10.1016/j.ctrv.2015.03.007
Cancer Treatment ReviewsVolume 41, Issue 5, May 2015, Pages 431–440
Laboratory-Clinic Interface Role of CD154 in cancer pathogenesis and immunotherapyGhada S. Hassan, John Stagg, Walid Mourad,