A new study from iBB, Instituto Superior Técnico, carried out within the scope of the FCT project “Mechanistic insights into adaptation and increased robustness to acetic acid and other weak acids toxicity in yeasts”, was published today in the journal Microbial Cell Factories. This study provides new biological knowledge of interest to gain further mechanistic insights into toxicity and tolerance to linear-chain monocarboxylic acids of increasing liposolubility and reports the first lists of tolerance genes, at the genome scale, for butyric and octanoic acids. These genes and biological functions are potential targets for synthetic biology approaches applied to promising yeast cell factories, towards more robust superior strains. This is a highly desirable phenotype to increase the economic viability of bioprocesses based on mixtures of volatiles/medium-chain fatty acids derived from low-cost biodegradable substrates or lignocellulose hydrolysates. The work was led by Prof. Isabel Sá-Correia and the two first co-authors are the PhD student of the Doctoral Programme in Biotechnology and Biosciences, Marta Mota, and the researcher with a MSc degree, Madalena Matos.
Check paper here.