iBB

The book G Protein-Coupled Receptor Screening Assays: Methods and Protocols, edited by Sofia Martins from INESC-MN and Miguel Prazeres from BERG-iBB, has just been published. This fully updated edition targets not only those assays directly involved in the discovery of GPCR-active compounds but also those involved in cell-based experiments designed to study physiological responses. Whether coming from academia or industry, or being an experienced researcher or a newcomer to the field, the reader will find accessible methods and protocols that cover the latest developments on receptor purification, molecular biology, recombinant engineering, and analytical techniques that enable the real time monitoring of the complex GPCR signaling cascade and identification of potential drug targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

The book G Protein Coupled Receptor Screening Assays: Methods and Protocols, edited by BERG-IBB researchers Sofia Martins and Miguel Prazeres, has just been published. The book reaches out to everyone involved in the discovery of GPCR-active drugs, and provides a transversal overview of the different levels of GPCR signaling addressable in the different screening strategies and presents practical examples of how current assay technologies are contributing to new paradigms in GPCR drug research. The book stems from the posto-doctoral work of Sofia Martins and features contributions from renowed specialists in the area. Click on title to learn more.