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Highlights
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A novel method to measure cellular antibody-uptake dynamics using imaging flow cytometry is presented
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This method allows an image-based analysis and quantification of population responses
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The method is established with an EpCAM-targeting antibody
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The uptake of two monoclonal antibodies targeting L1 at differing epitopes are determined
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We find contrasting internalization rates for L1 mAbs 9.3 and OV52.24
Via Krishan Maggon
doi:10.1016/j.jim.2015.04.024
Journal of Immunological MethodsAvailable online 9 May 2015
In Press, Accepted Manuscript — Note to users
A novel method for measuring cellular antibody uptake using imaging flow cytometry reveals distinct uptake rates for two different monoclonal antibodies targeting L1John Hazina, b, c, , , Gerhard Moldenhauera, Peter Altevogta, Nathan R. Bradyb, c