Mesothelioma risk endures over long-term
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Cancer - Advances, Knowledge, Integrative & Holistic Treatments
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Graham Player Ph.D.
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Graham Player Ph.D.'s insight:
In a study at the Salk Institute, Reuben Shaw, Professor of Molecular & Cell Biology says they have discovered a new anti-cancer gene that stops the spread of tumor cells throughout the body.
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PIAS3 levels, which brought down STAT3 activity and caused mesothelioma cells to die. Their study served as proof of principle about the effectiveness of these two compounds in treating malignant mesothelioma, a first step in moving a treatment toward clinical trials.
Graham Player Ph.D.'s insight:
The culprit in sparking many cancers, particularly mesothelioma, is the intracellular protein and transcription factor STAT3 (signal transducer and activator of transcription 3). A signal transducer and activator is a pathway for instructing the growth and survival of cells, and a transcription factor is a protein that controls genetic information directing cells how to perform. STAT3 is notorious for sending signals to trigger the onset of human cancers and to fuel their continued growth.
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Pleural and peritoneal mesothelioma are cancers that develop on the lining of the lungs and are almost always caused by asbestos exposure.
The Curtin University and UWA School of Public Health in Australia investigated 22,048 people exposed to asbestos across the globe. They found the rate and risk of pleural mesothelioma increased until 45 years after the first exposure. After 45 years the risk rate then appeared to slow down. However, the rate of peritoneal mesothelioma over 10-50 years continued to increase.