This clinical trial will test the safety of increasing doses of stem cells injected into the spinal cord of patients with ALS. There will be 15 - 18 patients in the study, separated into 5 dosing groups, A-E, with 3 patients in each group. The first 4 groups will receive injections into the cervical spinal cord in the neck, into the region that controls the breathing muscles. The subjects will receive either 5 (group A) or 10 (group B-E) injections on both sides of the spinal cord, for a total of either 10 or 20 injections. The number of cells will increase with each dosing group from 2 million to 8 million cells injected. Group E subjects will undergo two surgeries, first injections into the lumbar cord (lower spine) followed several weeks later by injections into the cervical spinal cord.
Eligible participants must all be able to....................